在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RHBDF2 Antibody, Biotin conjugated

RHBDF2 Antibody, Biotin conjugated

  • 中文名稱：
    RHBDF2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA744137LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RHBDF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6), RHBDF2, IRHOM2 RHBDL5 RHBDL6
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Inactive rhomboid protein 2 protein (1-200aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.
  • 基因功能參考文獻(xiàn)：
    1. Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers. PMID: 28128203
    2. Uev1A-Ubc13 complex catalyzes lysine63-linked ubiquitination of RHBDF2 to promote TACE maturation. PMID: 29069608
    3. The iRhom2 N-terminus stabilizes mature ADAM17 at the cell surface where it cleaves TNF and EGFR in inflammatory and innate immune responses. (Review) PMID: 28815577
    4. Tylosis with oesophageal cancer-associated mutations in iRHOM2 cause an increase in the maturation and activity of ADAM17 in epidermal keratinocytes. PMID: 24643277
    5. Our analyses suggest that these DNA methylation changes may have a role in the onset of Alzheimer disease given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known susceptibility gene network. PMID: 25129075
    6. Identification of a new missense mutation, p.Asp188Asn, segregating with tylosis with esophageal cancer in a Finnish family, and interestingly the detected mutation alters a codon located between the two previously reported mutation sites. PMID: 22638770
    7. RHBDF2 and CYGB may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease. PMID: 22344671
    8. The distribution of RHBDF2 in tylotic skin is altered in comparison with that in normal skin. PMID: 22265016

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Tylosis with esophageal cancer (TOC)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane.
  • 蛋白家族：
    Peptidase S54 family
  • 組織特異性：
    Found in the epidermis and esophageal epithelium.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20788

    OMIM: 148500

    KEGG: hsa:79651

    STRING: 9606.ENSP00000322775

    UniGene: Hs.464157



主站蜘蛛池模板： 国产原创av中文在线观看| 日本无码欧美一区精品久久| 国产乱子夫妻xx黑人xyx真爽| 国产精品久久久久久久久久久久午衣片 | 少妇人妻精品一区二区三区| 午夜免费视频| 国产成人免费无庶挡视频| 少妇无码av无码专区线y| 中文字幕av一区二区三区| 国産精品久久久久久久| 少妇被躁爽到高潮| 日本欧美亚洲中文在线观看| 少妇富婆高级按摩出水高潮| 久久久久久午夜成人影院| 精品久久久无码中文字幕边打电话| 亚洲国产精品尤物yw在线| 国产精品55夜色66夜色| 久热国产精品视频一区二区三区| 日本高清在线一区二区三区 | 永久免费的无码中文字幕| 伊人久久大香线蕉综合bd高清| 国产免费网站看v片在线无遮挡| 一区二区三区内射美女毛片| 男女猛烈无遮挡免费视频| 久久er热在这里只有精品66| 国产亚洲精品久久久久久入口| 无码啪啪熟妇人妻区| 天干夜天干天天天爽视频| 国产男女爽爽爽免费视频| 国产亚洲精品久久久久小| 高潮射精日本韩国在线播放| 国内精品久久久久久tv| 无尺码精品产品视频| 久热这里只有精品99| 中日韩精品视频在线观看| 色噜噜狠狠一区二区三区果冻| 麻豆精产一二三产区| 亚洲国产欧美中文丝袜日韩| 无码国内精品人妻少妇蜜桃视频| 亚洲成h人av无码动漫无遮挡| 亚洲乱码中文论理电影|