在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RGS14 Antibody

  • 中文名稱:
    RGS14兔多克隆抗體
  • 貨號(hào):
    CSB-PA019646GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Highly similar to rap1/rap2 interacting protein antibody; OTTHUMP00000223586 antibody; OTTHUMP00000223587 antibody; Regulation of G protein signaling 14 antibody; Regulator of G protein signaling 14 antibody; Regulator of G protein signalling 14 antibody; Regulator of G-protein signaling 14 antibody; RGS 14 antibody; RGS14 antibody; RGS14_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RGS14
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.
  • 基因功能參考文獻(xiàn):
    1. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS14 in fine-tuning TRPC4 activities. PMID: 26987813
    2. The RBD region associates with the RGS domain region, producing an intramolecular interaction within RGS14 that enhances the GTPase activating function. PMID: 23255434
    3. RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A PMID: 21880739
    4. RGS-14 may facilitate cognitive processing by modulating Cav1 channel-mediated intracellular divalent calcium ion Ca(2)+ transients. PMID: 20842066
    5. RGS14 serves as a novel scaffold to integrate GTP-Binding Protein alpha Subunit and Ras/Raf/MAPkinase signalling events through the action of its GL domain. PMID: 19878719
    6. We show that RGS14 is a component of mitotic asters formed in vitro from HeLa cell extracts and that depletion of RGS14 from cell extracts blocks aster formation. PMID: 15917656
    7. NMR 1H, 13C and 15N resonances of the RGS domain (residues 56-207) PMID: 19636837

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Nucleus, PML body. Cytoplasm. Membrane. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9996

    OMIM: 602513

    KEGG: hsa:10636

    STRING: 9606.ENSP00000386229

    UniGene: Hs.9347



主站蜘蛛池模板: 欧美成妇人吹潮在线播放| 亚洲熟女av乱码在线观看漫画| 激情综合色综合啪啪五月丁香搜索 | 蜜臀av999无码精品国产专区 | 乱中年女人伦av一区二区| 亚洲色婷婷婷婷五月基地 | 草色噜噜噜av在线观看香蕉| 丁香色婷婷国产精品视频| 韩国三级在线观看久| 制服 丝袜 亚洲 中文 综合| 久久不见久久见免费视频1′| 欧美日韩中文国产一区发布| 亚洲精品456在线播放| 一本久久a久久精品综合| 日韩av爽爽爽久久久久久| 国产成人精品亚洲精品| 国产精品久久久久久久久久红粉 | 国产欧美久久一区二区三区 | 中文天堂最新版在线www| 久久国产精品人妻丝袜| 巨大巨粗巨长 黑人长吊| 深夜福利视频在线播放 | 久本草在线中文字幕亚洲| 人妻系列无码专区久久五月天| 怀孕挺大肚子疯狂高潮av毛片| 伊人久久综合无码成人网| 高潮毛片无遮挡高清免费| 很色很爽很黄裸乳视频| 国产午夜精华2020在线| 久久久久亚洲精品成人网| 内射后入在线观看一区| 高大丰满熟妇丰满的大白屁股| 97人妻免费公开在线视频| 久久精品国产精品亚洲蜜月| 欧美成人片在线观看| 业余 自由 性别 成熟视频 视频 | 免费观看又污又黄在线观看| 日韩精品一区二区三区在线观看l| 欧美激烈精交gif动态图| 又黄又爽又色视频| 婷婷亚洲久悠悠色悠在线播放|