在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RGS14 Antibody

RGS14 Antibody

  • 中文名稱：
    RGS14兔多克隆抗體
  • 貨號(hào)：
    CSB-PA019646GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Highly similar to rap1/rap2 interacting protein antibody; OTTHUMP00000223586 antibody; OTTHUMP00000223587 antibody; Regulation of G protein signaling 14 antibody; Regulator of G protein signaling 14 antibody; Regulator of G protein signalling 14 antibody; Regulator of G-protein signaling 14 antibody; RGS 14 antibody; RGS14 antibody; RGS14_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human RGS14
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.
  • 基因功能參考文獻(xiàn)：
    1. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS14 in fine-tuning TRPC4 activities. PMID: 26987813
    2. The RBD region associates with the RGS domain region, producing an intramolecular interaction within RGS14 that enhances the GTPase activating function. PMID: 23255434
    3. RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A PMID: 21880739
    4. RGS-14 may facilitate cognitive processing by modulating Cav1 channel-mediated intracellular divalent calcium ion Ca(2)+ transients. PMID: 20842066
    5. RGS14 serves as a novel scaffold to integrate GTP-Binding Protein alpha Subunit and Ras/Raf/MAPkinase signalling events through the action of its GL domain. PMID: 19878719
    6. We show that RGS14 is a component of mitotic asters formed in vitro from HeLa cell extracts and that depletion of RGS14 from cell extracts blocks aster formation. PMID: 15917656
    7. NMR 1H, 13C and 15N resonances of the RGS domain (residues 56-207) PMID: 19636837

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Nucleus, PML body. Cytoplasm. Membrane. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9996

    OMIM: 602513

    KEGG: hsa:10636

    STRING: 9606.ENSP00000386229

    UniGene: Hs.9347



主站蜘蛛池模板： 99视频有精品视频高清| 久久久国产99久久国产久一| 国产成人久久久精品二区三区| 国产成人精品999视频| 早起邻居人妻奶罩太松av| 亚洲色欲综合一区二区三区| 卡一卡二卡三免费视频| 国产精品久久婷婷六月丁香| 国产精品久久无码不卡黑寡妇| 天堂√在线中文最新版| 精品人妻少妇一区二区| 伦人伦xxx国产对白| 中国熟妇牲交视频| 亚洲欧美偷国产日韩| 无码专区手机在线播放| 国产在线观看无码免费视频| 久久精品国产免费观看| 国产第一页屁屁影院| 国产成人亚洲日韩欧美| 中文字幕av无码一二三区电影| 亚洲熟女少妇一区二区| 老司机亚洲精品影院无码| 失禁潮痉挛潮喷av在线无码| av天堂久久精品影音先锋| 日韩v亚洲v欧美v精品综合| 国产在线无码一区二区三区视频| 久久欧美国产伦子伦精品| 亚洲 欧美 日韩 综合aⅴ电影| 亚洲精品国产美女久久久99| 无码人妻丰满熟妇奶水区码| 3d动漫精品啪啪一区二区免费 | 超薄丝袜足j好爽在线| www亚洲精品少妇裸乳一区二区 | 国产精品刮毛| 东京热加勒比视频一区| 亚洲综合色区中文字幕| 中文字幕人成乱码熟女app| 永久免费观看的毛片手机视频| 免费精品国偷自产在线2020| 国产成人精品免高潮在线观看| 波多野结衣av手机在线观看|