在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RANBP3 Antibody

RANBP3 Antibody

  • 中文名稱：
    RANBP3兔多克隆抗體
  • 貨號：
    CSB-PA019313GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RANBP3
  • 別名：
    DKFZp586I1520 antibody; Ran binding protein 3 antibody; Ran-binding protein 3 antibody; RANB3_HUMAN antibody; RanBP3 antibody
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Human RANBP3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
  • 基因功能參考文獻：
    1. Computational docking simulation indicates that phosphorylation of RanBP3 at Ser58 could potentially stabilize the association of RanBP3 with importin-alpha through interactions between the phosphate moiety of phospho-Ser58 of RanBP3 and a cluster of basic residues (Arg96 and Lys97 in importin-alpha3) on armadillo repeat 1 of importin-alpha. PMID: 28760339
    2. RANBP3 regulates melanoma cell proliferation and probably a potential target for molecular targeted therapy. PMID: 26763446
    3. RanBP3 is involved in vRNP nuclear export. The function of RanBP3 during vRNP nuclear export is regulated by phosphorylation at Ser58. RanBP3 phosphorylation is modulated by both PI3K/Akt and Ras/ERK/RSK pathways in the late phase of viral infection. PMID: 23303829
    4. Crystal structure of the Ran-binding domain (RBD) from RanBP3 and compare it to RBD structures from RanBP1 and RanBP2 in complex with Ran and CRM1. PMID: 21364925
    5. RanBP3 stimulates export by enhancing the affinity of Crm1 for Ran-GTP and cargo. PMID: 11932251
    6. A multifunctional domain in CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. PMID: 14612415
    7. RANBP3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. PMID: 18280241
    8. RanBP3 directly recognizes dephosphorylated Smad2/3, which results from the activity of nuclear Smad phosphatases, and mediates nuclear export of Smad2/3 in a Ran-dependent manner. PMID: 19289081

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Widely expressed with high levels in testis and heart.
  • 數據庫鏈接：

    HGNC: 9850

    OMIM: 603327

    KEGG: hsa:8498

    STRING: 9606.ENSP00000341483

    UniGene: Hs.531752



主站蜘蛛池模板： 久久久噜噜噜久噜久久| 国产热re99久久6国产精品首页| 国产丝袜视频一区二区三区| 国产成a人片在线观看视频下载| 亚洲另类无码专区丝袜| 亚洲欧美日韩国产成人一区| 日本污ww视频网站| 久久精品中文字幕| 人妻熟女 视频二区 视频一区| 国产一区二区不卡在线看| 国产老熟妇精品观看| 玩弄少妇人妻| 激情综合激情五月俺也去| 亚洲精品一区二区精华液| 插b内射18免费视频| 国产成a人亚洲精品无码樱花 | 无码少妇一区二区三区| 青青草免费公开视频| 亚洲欧洲免费无码| 成年无码动漫av片在线尤物| 精品久久久久久无码人妻vr| 一二三四区无产乱码1000集| 少妇放荡的呻吟干柴烈火动漫| 久久婷婷丁香七月色综合| 久久久久人妻一区精品果冻| 日韩人妻无码一区二区三区| 精品国际久久久久999| 中文人妻av大区中文不卡| 亚洲第一页综合图片自拍| 18禁美女黄网站色大片免费看| 综合激情久久综合激情| 欧美乱码卡一卡二卡四卡免费| 丰满人妻被黑人猛烈进入| 欧美大黑帍在线播放| 国产精品视频观看裸模| 午夜福利无码不卡在线观看| 免费观看18禁无遮挡真人网站 | 在线视频国产网址你懂的| 九九精品99久久久香蕉| 欧美日韩一区二区成人午夜电影| 伊人精品成人久久综合|