在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAMP2 Antibody

  • 中文名稱:
    RAMP2兔多克隆抗體
  • 貨號:
    CSB-PA019305GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    RAMP2; Receptor activity-modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RAMP2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
  • 基因功能參考文獻(xiàn):
    1. Single nucleotide polymorphism of RAMP2 is associated with Stroke. PMID: 28904253
    2. This work suggests that RAMP2 may modify the agonist activity and trafficking of the GCGR, with potential relevance to production of new peptide analogs with selective agonist activities. PMID: 28586439
    3. Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin for CTR ECD; the same appears to apply for enhanced affinity of amylin for RAMP2-CTR ECD. [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD = extracellular domain; RAMP2 = receptor (calcitonin) activity modifying protein 2]. PMID: 28614667
    4. This study reveals the glucagon receptor as a previously unidentified target for GLP-1 receptor agonists and highlights a role for RAMP2 in regulating its pharmacology. PMID: 26198634
    5. Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection. PMID: 24505304
    6. Data suggest isoforms of RAMP modulate accessibility of peptides to residues situated on CALCRL (calcitonin receptor-like receptor) N-terminal domain; RAMP3/RAMP2/RAMP1 appear to alter accessibility of specific residues at CALCRL-RAMP interface. PMID: 24199627
    7. RAMP2 gene expression increases with gestational age development in the fetal lung. PMID: 24169318
    8. Co-expression of calcitonin receptors (CT) lacking a portion of domain 1 with receptor activity-modifying protein (RAMP) 1, 2, or 3 appears to produce functional CT-(8-32)-sensitive adrenomedullin receptors. PMID: 12565884
    9. TNF-alpha induced time- and dose-dependent decreases in the expression of RAMP2 mRNA in cultured human coronary artery smooth muscle cells , thereby diminishing AM-evoked cAMP production PMID: 15245870
    10. Data found that expressions of RAMP1, RAMP2 and RAMP3 mRNAs increased with the worsening of heart function, but the expressions of RAMP1 and RAMP2 mRNA decreased at level IV of heart failure. PMID: 15300632
    11. adrenomedullin receptors are comprised of RAMP2 and calcitonin receptor-like receptor. PMID: 15613468
    12. This study reveals important functionality of the RAMP C-terminal domain and identifies key differences in the role of the RAMP C terminus for calcitonin receptor versus calcitonin receptor-like receptor-based receptors. PMID: 16912219
    13. RAMP2 is silenced by promoter hypermethylation in lung cancer PMID: 17671114
    14. Identification of RAMP2 residues for adrenomedullin receptors are reported. PMID: 18593822
    15. The His residues of hRAMP2 and -3 differentially govern adrenomedullin receptor function. PMID: 18835256

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    RAMP family
  • 組織特異性:
    Strongly expressed in lung, breast, immune system and fetal tissues.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9844

    OMIM: 605154

    KEGG: hsa:10266

    STRING: 9606.ENSP00000253796

    UniGene: Hs.514193



主站蜘蛛池模板: 欧美黑人又粗又大高潮喷水| 美女露全乳无遮掩视频| 国产杨幂av在线播放| 内射视频←www夜| 亚洲卡1卡2卡新区网站| 亚洲欧美日韩精品久久亚洲区| 女人喷潮完整视频| 国产精品人妻熟女男人的天堂| 99久久无色码中文字幕人妻| 久久精品免视看国产成人明星| 99久久久无码国产精品性| 久久av无码αv高潮αv喷吹| 色欲综合久久躁天天躁| 国产精品亚洲а∨天堂| 亚洲综合色区无码专区| 6080yyy午夜理论片中无码| 一本色道久久88精品综合| 日韩经典精品无码一区 | 人妻丰满熟妞av无码区| 国产精品久久久久久久久久免费| 国产成人亚洲精品无码车a| 久久亚洲美女精品国产精品| 国产麻豆精品一区二区三区v视界| 亚洲精品无码国产片| 亚洲最大av网站在线观看| 日产精品卡2卡三卡乱码网址| 久久人人超碰精品caoporen| 国产高清乱码又大又圆| 国产熟女亚洲精品麻豆| 亚洲一线二线三线写真| 欧美成人精品高清视频在线观看 | 69久久精品无码一区二区| 露脸内射熟女--69xx| 国产明星xxxx色视频| 久久久久久人妻毛片a片| yy111111少妇无码理论片| 国产精自产拍久久久久久蜜| 一本一道av无码中文字幕﹣百度| 亚洲中文无码人a∨在线| 丁香五月激情综合国产| 首页 综合国产 亚洲 丝袜|