在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAD23A Antibody, FITC conjugated

  • 中文名稱:
    RAD23A兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA03774C0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RAD23A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    hHR 23A antibody; hHR23A antibody; HR23A antibody; MGC111083 antibody; RAD 23a antibody; RAD23 homolog A (S. cerevisiae) antibody; RAD23 homolog A antibody; RAD23 yeast homolog A antibody; RAD23A antibody; RD23A_HUMAN antibody; UV excision repair protein RAD23 antibody; UV excision repair protein RAD23 homolog A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human UV excision repair protein RAD23 homolog A protein (2-201AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.
  • 基因功能參考文獻:
    1. Data indicate that HR23A protein-depleted cells exhibit enhanced autophagy when treated with DNA-damaging agents. PMID: 27613096
    2. HR23A role in DNA reapair, in protein degradation and stability, tumorigenesis and neurodegenerative disorders [review] PMID: 27771451
    3. hHR23A associates with Chk1 through its ubiquitin-associated domains, and knockdown of hHR23A increases and stabilizes the protein level of Chk1 and its phosphorylation at S347. PMID: 26296656
    4. Data indicate that phosphorylation provides a mechanism to regulate Rad23/proteasome interaction. PMID: 25311859
    5. Here, we show that hHR23A utilizes both the UBA2 and XPCB domains to form a stable complex with Vpr, linking Vpr directly to cellular DNA repair pathways and their probable exploitation by the virus. PMID: 24318982
    6. this study identified RAD23A as a novel negative regulator of RIG-I/MDA5 mediated anti-virus response. PMID: 23357418
    7. Determined is the three-dimensional structure of its ubiquitin-like (UbL) domain by X-ray crystallography. PMID: 21047872
    8. Vpr promotes hHR23A-mediated protein-ubiquitination, and down-regulation of hHR23A using RNAi significantly reduced viral replication in non-proliferating MAGI-CCR5 cells and primary macrophages PMID: 20614012
    9. involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination PMID: 11788722
    10. structures of the UBA domains of HHR23A reveal a conserved hydrophobic surface for protein-protein interactions PMID: 12079361
    11. the solution structures of the HHR23A Ubl domain PMID: 12970176
    12. Adopts a closed conformation and binds to the proteasomal subunit S5a thereby changing its own conformation. PMID: 14557549
    13. hHR23 binds to polyubiquitylated p53 via its carboxyl-terminal ubiquitin-associated (Uba) domain shielding p53 from deubiquitylation PMID: 14645509
    14. Data suggest that the UBL domain of HHR23A negatively regulates polyubiquitin/UBA interactions and identify leucine 8 of ubiquitin as an important determinant of chain recognition. PMID: 15321727
    15. hHR23A regulates the function of xeroderma pigmentosum C by its association with the nucleotide excision repair activator p53 PMID: 16105547
    16. Ufd4, the E3 component of the UFD pathway, is involved in controlling the degradation of Rad4, and Ufd4 and Rad23 exhibit a synthetic inhibitory effect on Rad4 degradation PMID: 16430867
    17. hHR23B thus plays a critical role in the activation and function of p53 after specific genotoxic exposures. PMID: 16924240
    18. hHR23a and hPLIC2 interact via UBL/UBA domain interactions PMID: 17098253
    19. Pyramidal crystals of the UbL domain of hHR23A were diffracted to beyond 2 A resolution and the structure was solved by molecular replacement. PMID: 19724136

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    RAD23 family
  • 數據庫鏈接:

    HGNC: 9812

    OMIM: 600061

    KEGG: hsa:5886

    STRING: 9606.ENSP00000467024

    UniGene: Hs.643267



主站蜘蛛池模板: 国产又色又刺激高潮视频| 国产精品福利视频萌白酱| 亚洲韩国日本高清一区| 天堂在线www资源| 国产日产久久高清欧美一区| 日韩中文字幕在线一区二区三区| 久久综合精品无码av一区二区三区| 国语对白刺激精品视频| 中文字幕v亚洲日本在线电影| 国产做爰xxxⅹ久久久精华液| 4hu四虎永久免费地址ww416| 亚洲国产成人极品综合| 中文字幕乱码免费专区| 欧美人与动牲交aⅴ| 少妇做爰免费视频网站| 国产情侣大量精品视频| 亚洲色欲色欲综合网站| 天天躁日日躁狠狠躁av麻豆| 女人高潮流白浆视频| 真实国产乱子伦视频| 在线视频国产网址你懂的| 色八区人妻在线视频免费| 国产成人一区二区三区在线| 羞羞色男人的天堂| 欧洲黑大粗无码免费| 国产精品福利视频导航| 亚洲精品无码久久久久| 无码天堂亚洲国产av麻豆| а天堂中文最新版在线| 成人欧美一区二区三区的电影| 亚洲图片自拍偷图区| 久久狼人大香伊蕉国产| 亚洲国产av精品一区二区蜜芽 | 色一情一乱一伦一视频免费看| 久久中文字幕无码a片不卡古代| 丰满少妇做爰视频爽爽和| 天天爱天天做狠狠久久做| 免费男人下部进女人下部视频| 美女被啪到深处抽搐视频| 亚洲中久无码永久在线观看同 | 免费不卡无码av在线观看|