在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAD23A Antibody, Biotin conjugated

  • 中文名稱:
    RAD23A兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA03774D0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RAD23A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    hHR 23A antibody; hHR23A antibody; HR23A antibody; MGC111083 antibody; RAD 23a antibody; RAD23 homolog A (S. cerevisiae) antibody; RAD23 homolog A antibody; RAD23 yeast homolog A antibody; RAD23A antibody; RD23A_HUMAN antibody; UV excision repair protein RAD23 antibody; UV excision repair protein RAD23 homolog A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human UV excision repair protein RAD23 homolog A protein (2-201AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.
  • 基因功能參考文獻:
    1. Data indicate that HR23A protein-depleted cells exhibit enhanced autophagy when treated with DNA-damaging agents. PMID: 27613096
    2. HR23A role in DNA reapair, in protein degradation and stability, tumorigenesis and neurodegenerative disorders [review] PMID: 27771451
    3. hHR23A associates with Chk1 through its ubiquitin-associated domains, and knockdown of hHR23A increases and stabilizes the protein level of Chk1 and its phosphorylation at S347. PMID: 26296656
    4. Data indicate that phosphorylation provides a mechanism to regulate Rad23/proteasome interaction. PMID: 25311859
    5. Here, we show that hHR23A utilizes both the UBA2 and XPCB domains to form a stable complex with Vpr, linking Vpr directly to cellular DNA repair pathways and their probable exploitation by the virus. PMID: 24318982
    6. this study identified RAD23A as a novel negative regulator of RIG-I/MDA5 mediated anti-virus response. PMID: 23357418
    7. Determined is the three-dimensional structure of its ubiquitin-like (UbL) domain by X-ray crystallography. PMID: 21047872
    8. Vpr promotes hHR23A-mediated protein-ubiquitination, and down-regulation of hHR23A using RNAi significantly reduced viral replication in non-proliferating MAGI-CCR5 cells and primary macrophages PMID: 20614012
    9. involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination PMID: 11788722
    10. structures of the UBA domains of HHR23A reveal a conserved hydrophobic surface for protein-protein interactions PMID: 12079361
    11. the solution structures of the HHR23A Ubl domain PMID: 12970176
    12. Adopts a closed conformation and binds to the proteasomal subunit S5a thereby changing its own conformation. PMID: 14557549
    13. hHR23 binds to polyubiquitylated p53 via its carboxyl-terminal ubiquitin-associated (Uba) domain shielding p53 from deubiquitylation PMID: 14645509
    14. Data suggest that the UBL domain of HHR23A negatively regulates polyubiquitin/UBA interactions and identify leucine 8 of ubiquitin as an important determinant of chain recognition. PMID: 15321727
    15. hHR23A regulates the function of xeroderma pigmentosum C by its association with the nucleotide excision repair activator p53 PMID: 16105547
    16. Ufd4, the E3 component of the UFD pathway, is involved in controlling the degradation of Rad4, and Ufd4 and Rad23 exhibit a synthetic inhibitory effect on Rad4 degradation PMID: 16430867
    17. hHR23B thus plays a critical role in the activation and function of p53 after specific genotoxic exposures. PMID: 16924240
    18. hHR23a and hPLIC2 interact via UBL/UBA domain interactions PMID: 17098253
    19. Pyramidal crystals of the UbL domain of hHR23A were diffracted to beyond 2 A resolution and the structure was solved by molecular replacement. PMID: 19724136

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    RAD23 family
  • 數據庫鏈接:

    HGNC: 9812

    OMIM: 600061

    KEGG: hsa:5886

    STRING: 9606.ENSP00000467024

    UniGene: Hs.643267



主站蜘蛛池模板: 国内精品久久久久影院一蜜桃| 国产亚洲va在线电影| 狠日狠干日日射| 人妻无码第一区二区三区| 国产精品久久久天天影视| 中文字幕在线观看亚洲视频| 日日噜噜夜夜狠狠久久无码区| 97久久超碰精品视觉盛宴| 香蕉视频在线精品视频| 国产女爽爽精品视频天美传媒| 色妞精品av一区二区三区| 亚洲卡一卡二卡三新区乱码| 中文字幕在线日亚洲9| 天码av无码一区二区三区四区| 国产高清午夜人成在线观看 | 亚洲综合色在线观看一区| 亚洲高清国产拍精品闺蜜合租| 日日噜噜夜夜爽爽| 波多野结衣av在线无码中文18 | 黑人大战欲求不满人妻| 人人妻人人澡人人爽秒播| 无码任你躁久久久久久老妇 | 亚洲国产精品久久亚洲精品| 99国产成人精品视频| 日本中文一区二区三区亚洲| 婷婷亚洲综合五月天小说| 99久久久无码国产精品秋霞网 | 久久精品人人槡人妻人| 久久久亚洲欧洲日产国码二区| 亚洲精品成av人片天堂无码| 日韩无码电影| 日本中文字幕一区二区有码在线| 国产精品99爱免费视频| 99精品电影一区二区免费看| 国产一区二区野外| 久久只有这里有精品4| 天天摸天天做天天爽| 亚洲人成小说网站色在线| 国产1卡2卡3卡4卡免费| 日韩高清国产一区在线| 男人的天堂av网站|