在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAB3A Antibody, HRP conjugated

RAB3A Antibody, HRP conjugated

  • 中文名稱：
    RAB3A兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA019194LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RAB3A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Rab 3A antibody; RAB 3A member RAS oncogene family antibody; Rab3a antibody; RAB3A member RAS oncogene family antibody; RAB3A_HUMAN antibody; RAS associated protein RAB 3A antibody; RAS associated protein RAB3A antibody; Ras related protein Rab 3A antibody; Ras related protein Rab3A antibody; Ras-related protein Rab-3A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rab-3A protein (1-220AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction.
  • 基因功能參考文獻：
    1. Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release. PMID: 27613869
    2. Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells. PMID: 24965146
    3. Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein. PMID: 25713146
    4. Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified PMID: 24652202
    5. alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity PMID: 23344955
    6. Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. PMID: 22753498
    7. Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles PMID: 21349835
    8. a possible role in glomerulopathies PMID: 12937130
    9. Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. PMID: 15005721
    10. Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association. PMID: 16099449
    11. In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population. PMID: 16584842
    12. Initiates exocytosis in acrosome when prenylated and activated with guanosine triphosphate (GTP). PMID: 17625073
    13. Rab3GEP has a role as the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes PMID: 18559336
    14. Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis PMID: 19546222
    15. The maturation of amyloid precursor protein (APP) transport vesicles, including recruitment of conventional kinesin, requires Rab3A GTPase activity. PMID: 19923287

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Lysosome. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 組織特異性：
    Specifically expressed in brain.
  • 數據庫鏈接：

    HGNC: 9777

    OMIM: 179490

    KEGG: hsa:5864

    STRING: 9606.ENSP00000222256

    UniGene: Hs.27744



主站蜘蛛池模板： 国产欧美精品区一区二区三区| 影音先锋日日狠狠久久| 国产美女精品中文网蜜芽宝贝| 国产一在线精品一区在线观看| 亚洲一区精品无码| 伊人久久大香线蕉综合直播| 18禁黄污无遮挡无码网站| 免免费国产aaaaa片| 一个人看的日本hd免费| 亚洲欧洲成人av每日更新| 人人澡人人曰人人摸看| 884aa四虎影成人精品| 亚洲国产精品无码久久98| 亚洲乱码无码永久不卡在线| 最新无码人妻在线不卡| 亚洲老熟女与小伙bbwtv| 国产女人高潮叫床视频| 天堂mv在线mv免费mv香蕉| 亚洲一区爱区精品无码| 亚洲男人天堂| 97色伦图片97综合影院| 欧美肥胖老太vidio在线视频| 少妇人妻久久无码专区| 欧美日韩在线视频一区| 国产成人小视频| 久久国产乱子伦精品免费女人| 久久精品中文字幕有码| 国产精品第12页| 囯产精品久久久久久久久久妞妞| 婷婷综合缴情亚洲狠狠| 18女下面流水不遮图| av色综合久久天堂av色综合在| 18处破外女出血在线| av无码av在线a∨天堂app| 国产精品免费看久久久| 亚洲综合在线另类色区奇米| 影音先锋无码a∨男人资源站| 国产18禁黄网站免费观看| 狠狠色噜噜狠狠狠狠777米奇| 国产精品亚洲欧美大片在线观看| 18禁成年无码免费网站|