在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAB3A Antibody, FITC conjugated

RAB3A Antibody, FITC conjugated

  • 中文名稱：
    RAB3A兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA019194LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RAB3A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Rab 3A antibody; RAB 3A member RAS oncogene family antibody; Rab3a antibody; RAB3A member RAS oncogene family antibody; RAB3A_HUMAN antibody; RAS associated protein RAB 3A antibody; RAS associated protein RAB3A antibody; Ras related protein Rab 3A antibody; Ras related protein Rab3A antibody; Ras-related protein Rab-3A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rab-3A protein (1-220AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction.
  • 基因功能參考文獻：
    1. Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release. PMID: 27613869
    2. Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells. PMID: 24965146
    3. Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein. PMID: 25713146
    4. Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified PMID: 24652202
    5. alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity PMID: 23344955
    6. Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. PMID: 22753498
    7. Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles PMID: 21349835
    8. a possible role in glomerulopathies PMID: 12937130
    9. Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. PMID: 15005721
    10. Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association. PMID: 16099449
    11. In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population. PMID: 16584842
    12. Initiates exocytosis in acrosome when prenylated and activated with guanosine triphosphate (GTP). PMID: 17625073
    13. Rab3GEP has a role as the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes PMID: 18559336
    14. Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis PMID: 19546222
    15. The maturation of amyloid precursor protein (APP) transport vesicles, including recruitment of conventional kinesin, requires Rab3A GTPase activity. PMID: 19923287

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Lysosome. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 組織特異性：
    Specifically expressed in brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9777

    OMIM: 179490

    KEGG: hsa:5864

    STRING: 9606.ENSP00000222256

    UniGene: Hs.27744



主站蜘蛛池模板： 国产精品久久久久永久免费看| 成年无码a√片在线观看| 人人爽人人片人人片av| 成 人 色 网 站免费观看| 日产精品一区2区卡四卡二卡| av影音先锋最大资源网| 中文在线www天堂网| 日韩av无码中文无码不卡电影| 日韩人妻无码一区二区三区久久99| 国产成人精品日本亚洲| 欧美丰满熟妇多毛xxxxx| 亚洲成av人片天堂网无码】| 国产一码二码三码区别| 国产午夜福利100集发布| 曰批免费视频播放免费直播| 日本二区三区欧美亚洲国产| 亚洲中文字幕无码爆乳av| 国产亚洲日韩在线三区| 中文字幕无码热在线视频| 又粗又长又硬义又黄又爽| 少妇人妻互换不带套| 午夜在线a亚洲v天堂网2018| 97se亚洲国产综合自在线| 思思久久99热只有频精品66| 久久久精品国产sm最大网站| 免费看无码自慰一区二区| 色欲天天婬色婬香综合网| 欧美 变态 另类 人妖| 久久久亚洲色| 久热中文字幕无码视频| 亚洲国产精品尤物yw在线观看| 69久久精品无码一区二区| 伦理片午夜视频在线观看| 97精品国产一区二区三区四区| 久久久久无码国产精品一区| 国产va免费精品高清在线| 亚洲精品午夜一区人人爽| 国内精品久久久久久久小说| 亚洲中文字幕久久无码精品| 97超碰国产精品无码分类| 把插八插露脸对白内射|