在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAB35 Antibody

RAB35 Antibody

  • 中文名稱：
    RAB35兔多克隆抗體
  • 貨號：
    CSB-PA140113
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA140113(RAB35 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA140113(RAB35 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GTP binding protein RAY antibody; GTP-binding protein RAY antibody; H ray antibody; OTTHUMP00000240256 antibody; OTTHUMP00000240257 antibody; OTTHUMP00000240258 antibody; OTTHUMP00000240259 antibody; RAB1C antibody; Rab35 antibody; RAB35 member RAS oncogene family antibody; RAB35; member RAS oncogene family antibody; RAB35_HUMAN antibody; Ras related protein rab 1c (GTP binding protein ray) antibody; Ras related protein Rab 1C antibody; Ras related protein Rab35 antibody; Ras-related protein Rab-1C antibody; Ras-related protein Rab-35 antibody; RAY antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human RAB35
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.
  • 基因功能參考文獻：
    1. A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration. PMID: 29662076
    2. The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion. PMID: 27430308
    3. The involvement of Rab35 in diverse and apparently unrelated cellular functions can be explained by the central role of this GTPase in regulating phosphoinositides and F-actin, both on endosomes and at the plasma membrane[review]. PMID: 27329675
    4. Data suggest that Rab35, interacting with TBC1D10A, functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 and Arf6. (Rab35 = rab GTP-binding protein 53; TBC1D10A = TBC1 domain family member 10A; ACAP2 = centaurin beta2; Arf6 = ADP-ribosylation factor 6) PMID: 28566286
    5. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35. PMID: 27238570
    6. Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 during infection. PMID: 27261256
    7. Authors propose that the precise spatial and temporal activation of Rab35 acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking. PMID: 26725203
    8. Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes. PMID: 25988331
    9. the activation-inactivation cycles of Rab35 and ARF6 are required for the uptake of zymosan and that ACAP2 is an important component that links Rab35/ARF6 signaling during phagocytosis of zymosan. PMID: 26229970
    10. Two somatic RAB35 mutations found in human tumors generate alleles that constitutively activate PI3K/AKT signaling, suppress apoptosis, and transform cells in a PI3K-dependent manner. PMID: 26338797
    11. mutual regulation with arf6 of cell adhesion and migration PMID: 23264734
    12. Rab35 acts as a downstream target of Dvl2 and mediates cell migration. PMID: 23353182
    13. Activated ARF6 reduces Rab35 loading into the endocytic pathway. PMID: 22226746
    14. whereas connecdenn 1 and 2 activate Rab35 for endosomal trafficking, connecdenn 3 uniquely activates Rab35 for its role in actin regulation PMID: 22072793
    15. analysis of DENND1B-S complexed with its substrate Rab35 PMID: 22065758
    16. the phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) 5-phosphatase OCRL, which is mutated in Lowe syndrome patients, is an effector of the Rab35 GTPase in cytokinesis abscission PMID: 21706022
    17. A Small Ras-like GTPase protein Ray was indicated to modulate p53 transcriptional activity of PRPK. PMID: 16600182
    18. localized to the plasma membrane and endocytic compartments and controls a fast endocytic recycling pathway; plays an essential role during the terminal steps of cytokinesis PMID: 16950109
    19. EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to immunological synapse formation, most likely by participating in TCR transport to the immunological synapse PMID: 18450757
    20. study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin, which directly associated with active Rab35 PMID: 19729655

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Melanosome.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 數據庫鏈接：

    HGNC: 9774

    OMIM: 604199

    KEGG: hsa:11021

    STRING: 9606.ENSP00000229340

    UniGene: Hs.524788



主站蜘蛛池模板： 人人妻人人爽人人澡欧美一区| 未满小14洗澡无码视频网站 | 人人妻人人澡人人爽人人dvd| 免费看少妇作爱视频| 久久久精品人妻一区二区三区| 国产av成人精品播放| 日本少妇xxx做受| 亚洲嫩模喷白浆在线观看| 狠狠躁天天躁中文字幕无码| 亚洲第一区无码专区| 久久er热在这里只有精品66| 做性久久久久久| 日本大香伊一区二区三区| 2019nv天堂香蕉在线观看| a国产在线v的不卡视频| 久久亚洲精品无码av宋| 97人妻熟女成人免费视频色戒| 欧美日韩在线第一页免费观看 | 亚洲欧美日韩成人综合一区| 天天摸天天摸天天天天看| 人妻av无码专区久久| 四虎永久地址www成人| 日本亲与子乱人妻hd| 亚洲色大网站www永久网站| 人妻熟女久久久久久久| 亚洲日韩一区二区| 色偷偷88888欧美精品久久久| 国产α片免费观看在线人 | 亚洲精品无码永久在线观看性色 | 国产午夜永久福利视频在线观看| 中文在线8资源库| 日产精品一区2区卡四卡二卡| 国产亚洲中文字幕在线制服| 欧美18videosex性欧美黑吊 | 国产人妻777人伦精品hd| 狠狠热精品免费视频| 国产午夜精品一区二区三区极品 | 九九热久久只有精品2| 免费拍拍拍网站| 熟女少妇精品一区二区| 久久亚洲国产最新网站之一|