在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAB11B Antibody, HRP conjugated

RAB11B Antibody, HRP conjugated

  • 中文名稱：
    RAB11B兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA614903LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RAB11B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GTP binding protein YPT3 antibody; GTP-binding protein ypt3 antibody; H-YPT3 antibody; RAB 11A antibody; RAB11B antibody; RAB11B member RAS oncogene family antibody; RAB11B; member of RAS oncogene family antibody; Ras related protein Rab 11B antibody; RAS-associated protein RAB11B antibody; Ras-related protein Rab-11B antibody; RB11B_HUMAN antibody; YPT3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rab-11B protein (2-215AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
  • 基因功能參考文獻：
    1. Recurrent de novo mutations disturbing the GTP/GDP binding pocket of RAB11B cause intellectual disability and a distinctive brain phenotype. PMID: 29106825
    2. High RAB11B expression is associated with pancreatic cancer. PMID: 27481517
    3. we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions PMID: 25070890
    4. Upon Rab11b depletion, FGFR4 is trapped in the pericentriolar recycling compartment. PMID: 24589086
    5. the predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by Rab11b through remodeling of the melanosome membrane, followed by subsequent endocytosis by keratinocytes PMID: 24141907
    6. Data show that the cAMP/PKA/CREB signaling pathway initiates acidosis-induced V-ATPase trafficking in salivary ducts via regulation of Rab11b expression. PMID: 22561749
    7. These findings reveal a novel role for Rab11b in limiting, rather than promoting, the plasma membrane expression of Cav1.2 L-type Ca2+ channels. PMID: 21248079
    8. These data introduce Rab11b as a crucial regulator and Rip11 as mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland. PMID: 20717956
    9. propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature Inner Membrane Complex of the growing daughter parasites. PMID: 20686666
    10. structural analysis shows Rab11 isoforms may possess different GTP hydrolysis rates PMID: 16545962
    11. This is the first report detailing apical CFTR recycling in a native expression system and to demonstrate that Rab11b regulates apical recycling in polarized epithelial cells. PMID: 19244346

    顯示更多

    收起更多

  • 亞細胞定位：
    Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 數據庫鏈接：

    HGNC: 9761

    OMIM: 604198

    KEGG: hsa:9230

    STRING: 9606.ENSP00000333547

    UniGene: Hs.558403



主站蜘蛛池模板： 欧美牲交视频免费观看 | 小说区 图片区色 综合区| 乱色精品无码一区二区国产盗| 亚洲精品无码久久久久| 亚洲成a∨人片在无码2023| 中文字幕乱码久久午夜不卡| 国产69精品久久久久孕妇| 国产成人无码短视频| 无码熟妇人妻av| 嫩b人妻精品一区二区三区| 亚洲第一最快av网站| 国内免费视频成人精品| 一本一本久久a久久精品综合麻豆| 久久久久99精品国产片| 无码一区二区三区| 人妻三级日本香港三级极| 国产免费二卡3卡四卡| 人妻av中文字幕无码专区| 色狠狠久久av五月综合| 女性自慰网站免费看ww| 国产精品久久久久电影网| 欧美最猛黑人xxxxx猛交| 无码国产精品一区二区高潮| 中文字幕第一区高清av| 亚洲图片校园另激情类小说| 人妻体验按摩到忍不住哀求继续| 男受被做哭激烈娇喘gv视频| 日本人妻伦在线中文字幕| 成人做受视频试看120秒| 玩弄放荡人妻少妇系列| 人妻熟女一区二区aⅴ千叶宁真| 久久人人爽人人爽人人av东京热 | 国内揄拍国产精品人妻门事件 | 精品国产天线2019| 日本十八禁视频无遮挡| 四虎成人永久在线精品免费| 97se亚洲精品一区二区| 欧美精品一区二区蜜臀亚洲 | 中文字幕日产熟女乱码| 欲色欲色天天天www| 国产午夜精品av一区二区|