在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAB11B Antibody, FITC conjugated

RAB11B Antibody, FITC conjugated

  • 中文名稱：
    RAB11B兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA614903LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RAB11B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GTP binding protein YPT3 antibody; GTP-binding protein ypt3 antibody; H-YPT3 antibody; RAB 11A antibody; RAB11B antibody; RAB11B member RAS oncogene family antibody; RAB11B; member of RAS oncogene family antibody; Ras related protein Rab 11B antibody; RAS-associated protein RAB11B antibody; Ras-related protein Rab-11B antibody; RB11B_HUMAN antibody; YPT3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rab-11B protein (2-215AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
  • 基因功能參考文獻：
    1. Recurrent de novo mutations disturbing the GTP/GDP binding pocket of RAB11B cause intellectual disability and a distinctive brain phenotype. PMID: 29106825
    2. High RAB11B expression is associated with pancreatic cancer. PMID: 27481517
    3. we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions PMID: 25070890
    4. Upon Rab11b depletion, FGFR4 is trapped in the pericentriolar recycling compartment. PMID: 24589086
    5. the predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by Rab11b through remodeling of the melanosome membrane, followed by subsequent endocytosis by keratinocytes PMID: 24141907
    6. Data show that the cAMP/PKA/CREB signaling pathway initiates acidosis-induced V-ATPase trafficking in salivary ducts via regulation of Rab11b expression. PMID: 22561749
    7. These findings reveal a novel role for Rab11b in limiting, rather than promoting, the plasma membrane expression of Cav1.2 L-type Ca2+ channels. PMID: 21248079
    8. These data introduce Rab11b as a crucial regulator and Rip11 as mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland. PMID: 20717956
    9. propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature Inner Membrane Complex of the growing daughter parasites. PMID: 20686666
    10. structural analysis shows Rab11 isoforms may possess different GTP hydrolysis rates PMID: 16545962
    11. This is the first report detailing apical CFTR recycling in a native expression system and to demonstrate that Rab11b regulates apical recycling in polarized epithelial cells. PMID: 19244346

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9761

    OMIM: 604198

    KEGG: hsa:9230

    STRING: 9606.ENSP00000333547

    UniGene: Hs.558403



主站蜘蛛池模板： 99精品久久99久久久久| 欧美最新精品videossexohd | 国产亚洲精品久久久久秋霞| 亚洲熟妇久久国内精品| 欧美老肥熟妇多毛xxxxx| 亚洲一卡二卡三卡四卡无卡麻豆 | 国产女女做受ⅹxx高潮| 少妇扒开粉嫩小泬视频| 精品噜噜噜噜久久久久久久久| 亚洲欧洲自拍拍偷综合| 国产又黄又爽胸又大免费视频| 日韩经典午夜福利发布| 无码国产精品一区二区免费vr| 亚洲欧美成人久久一区| 玩弄少妇人妻中文字幕| 69精品人人人人| 日韩精品无码成人专区| 亚洲精品国产一二三无码av| 真人无码作爱免费视频| 小sao货水好多真紧h无码视频| 日韩精品一区二区三区中文| 国产粉嫩小泬在线观看泬| 免费无码专区在线视频| 国产成人精品亚洲日本在线| 特级无码毛片免费视频播放▽ | 小污女导航福利入口| 欧美日韩国产精品| 人妻夜夜爽天天爽三区| 成人午夜亚洲精品无码区毛片| 国产色诱视频在线播放网站| 一区二区三区国产| 精品三级av无码一区| 玩弄丰满熟妇xxxxx性60| 亚洲午夜精品久久久久久app| 一边添奶一边添p好爽视频| 日韩av无码社区一区二区三区| 日本动漫瀑乳h动漫啪啪免费| 免费人成视频x8x8| 国产在线视频精品视频| 国产午夜人做人免费视频网站| 亚洲色大成网站www永久男同|