在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

QSOX1 Antibody

  • 中文名稱:
    QSOX1兔多克隆抗體
  • 貨號:
    CSB-PA019144LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Rat heart tissue
      All lanes: QSOX1 antibody at 5.6μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 83 kDa
      Observed band size: 83 kDa
    • IHC image of CSB-PA019144LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA019144LA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) QSOX1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    QSOX1; QSCN6; UNQ2520/PRO6013; Sulfhydryl oxidase 1; hQSOX; Quiescin Q6
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Sulfhydryl oxidase 1 protein (101-175AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,QSOX1 Antibody (CSB-PA019144LA01HU),的標記方式是Non-conjugated。對于QSOX1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA019144LB01HU QSOX1 Antibody, HRP conjugated ELISA
    FITC CSB-PA019144LC01HU QSOX1 Antibody, FITC conjugated
    Biotin CSB-PA019144LD01HU QSOX1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
  • 基因功能參考文獻:
    1. This study provides a key example of the effect of glycosylation on Golgi exit and contributes to an understanding of late secretory sorting and quality control. PMID: 29757379
    2. High QSOX1 expression correlates with tumor invasiveness PMID: 29804717
    3. High QSOX1 expression is a strong and independent factor of reduced survival in breast cancer and may represent a biomarker for aggressive disease and a potential treatment target PMID: 27562495
    4. Data indicate ebselen as an in vitro inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1) enzymatic activity. PMID: 26158899
    5. QSOX1 immunoexpression was observed in the non-neoplastic cerebellum samples and the medulloblastoma samples PMID: 25908093
    6. High levels of QSOX1 RNA expression is associated with breast cancer. PMID: 23536962
    7. these studies suggest that QSOX1 is a predictive biomarker for luminal cancers and that it may be a useful target for elusive luminal B disease PMID: 23680167
    8. QSOX1 may be revealed as an important player in cancer detection and prognosis. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo models will provide important insights into how to target QSOX1 with anti-neoplastic agents. PMID: 24359107
    9. Examination of the unusual kinetics of QSOX1 toward cysteine and glutathione at low micromolar concentrations suggests that circulating QSOX1 is unlikely to significantly contribute to the oxidation of these monothiols in plasma PMID: 24468475
    10. QSOX1 may be involved in neuroblastoma differentiation and regression and may thus function as a biomarker for identifying risk groups for this neoplasm. PMID: 24704990
    11. QSOX1 is induced by hypoxic stimuli and identified that QSOX1 is a direct target of HIF-1. PMID: 24008827
    12. Data suggest that isoenzyme QSOX1A is secreted from mammalian cells despite transmembrane domain; QSOX1A is cleaved at internal sites and processed within Golgi apparatus to yield soluble enzyme that forms dimer upon cleavage of C-terminal domain. PMID: 23713614
    13. QSOX1 is a potential new prognostic marker which may prove of use in the staging of breast tumours and the stratification of breast cancer patients. PMID: 23460839
    14. QSOX1 activity was required for incorporation of laminin into the extracellular matrix (ECM) synthesized by fibroblasts, and ECM produced without QSOX1 was defective in supporting cell-matrix adhesion. PMID: 23704371
    15. crystal structure PMID: 22801504
    16. These results propose for the first time possible roles for QSOX1 in atherosclerosis. PMID: 22069028
    17. Taken together, our results suggest that the mechanism of QSOX1-mediated tumor cell invasion is by activation of MMP-2 and MMP-9. PMID: 21989104
    18. Data suggested that the C449-C452 motif was essential for the activity of human QSOX 1b; the C70-C73 motif was fundamental in electron transfer from thiol-containing substrate including reduced proteins, DTT, GSH. PMID: 21148546
    19. A partial QSOX1 crystal structure reveals a single-chain pseudo-dimer mimicking the quaternary structure of Erv enzymes. PMID: 20211621
    20. In the plasma peptidome of patients with ductal adenocarcinoma of the pancreas (DAP), a prominent peptide was identified from the QSOX1 parent protein. This peptide was present in 16 of 23 DAP patients and 4 of 5 patients with IPMN. PMID: 19795908
    21. Data show that the longer version of human QSOX1 protein (hQSOX1a) is a transmembrane protein localized primarily to the Golgi apparatus, and that hQSOX1a can act in vivo as an oxidase. PMID: 17331072
    22. internal redox steps studied by mutagenesis PMID: 18393449

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Golgi apparatus membrane; Single-pass membrane protein. Secreted.; [Isoform 2]: Secreted.
  • 蛋白家族:
    Quiescin-sulfhydryl oxidase (QSOX) family
  • 組織特異性:
    Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.
  • 數據庫鏈接:

    HGNC: 9756

    OMIM: 603120

    KEGG: hsa:5768

    STRING: 9606.ENSP00000356574

    UniGene: Hs.744925



主站蜘蛛池模板: 日本中文字幕一区二区有码在线| 无码人妻h动漫中文字幕| 欧洲国产伦久久久久久久| 狠狠色综合网站久久久久久久| 国产av老师丝袜美腿丝袜| 欧美天天拍在线视频| 亚洲精品无码国产片| 国产艳妇av在线观看果冻传媒| 嫖妓丰满肥熟妇在线精品| 精品日产一卡二卡| 精品无码国产自产拍在线观看| 黑人巨茎美女高潮视频| 国产真实露脸乱子伦原著| 国产成人8x人在线视频软件| 国产v在线最新观看视频| 国产精品久久久午夜夜伦鲁鲁| 99在线精品免费视频| 猫咪www免费人成网站无码| 亚洲日产韩国一二三四区| 无码喷水一区二区浪潮av| 胸大美女又黄的网站| 久久久亚洲色| 男女扒开双腿猛进入免费看污| 日韩在线不卡免费视频一区| 亚洲国产成人一区二区在线| 久久超碰97人人做人人爱| 亚洲精品国产自在现线最新| 午夜精品久久久久久久喷水| 99久久精品国产一区二区三区| 成人国产精品无码网站| 少妇愉情理伦片丰满丰满| 国产超碰人人爽人人做人人添| 国产成人精品高清在线观看99| 精品aⅴ一区二区三区| 99热在线精品国产观看| 人妻av中文系列| 久久婷婷五月综合97色直播| 狼友网精品视频在线观看| 国产亚洲综合欧美一区二区| 欧美黑人添添高潮a片www| 国产爆乳无码视频在线观看|