在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

QSOX1 Antibody, HRP conjugated

  • 中文名稱:
    QSOX1兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA019144LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) QSOX1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    QSOX1; QSCN6; UNQ2520/PRO6013; Sulfhydryl oxidase 1; hQSOX; Quiescin Q6
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Sulfhydryl oxidase 1 protein (101-175AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
  • 基因功能參考文獻(xiàn):
    1. This study provides a key example of the effect of glycosylation on Golgi exit and contributes to an understanding of late secretory sorting and quality control. PMID: 29757379
    2. High QSOX1 expression correlates with tumor invasiveness PMID: 29804717
    3. High QSOX1 expression is a strong and independent factor of reduced survival in breast cancer and may represent a biomarker for aggressive disease and a potential treatment target PMID: 27562495
    4. Data indicate ebselen as an in vitro inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1) enzymatic activity. PMID: 26158899
    5. QSOX1 immunoexpression was observed in the non-neoplastic cerebellum samples and the medulloblastoma samples PMID: 25908093
    6. High levels of QSOX1 RNA expression is associated with breast cancer. PMID: 23536962
    7. these studies suggest that QSOX1 is a predictive biomarker for luminal cancers and that it may be a useful target for elusive luminal B disease PMID: 23680167
    8. QSOX1 may be revealed as an important player in cancer detection and prognosis. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo models will provide important insights into how to target QSOX1 with anti-neoplastic agents. PMID: 24359107
    9. Examination of the unusual kinetics of QSOX1 toward cysteine and glutathione at low micromolar concentrations suggests that circulating QSOX1 is unlikely to significantly contribute to the oxidation of these monothiols in plasma PMID: 24468475
    10. QSOX1 may be involved in neuroblastoma differentiation and regression and may thus function as a biomarker for identifying risk groups for this neoplasm. PMID: 24704990
    11. QSOX1 is induced by hypoxic stimuli and identified that QSOX1 is a direct target of HIF-1. PMID: 24008827
    12. Data suggest that isoenzyme QSOX1A is secreted from mammalian cells despite transmembrane domain; QSOX1A is cleaved at internal sites and processed within Golgi apparatus to yield soluble enzyme that forms dimer upon cleavage of C-terminal domain. PMID: 23713614
    13. QSOX1 is a potential new prognostic marker which may prove of use in the staging of breast tumours and the stratification of breast cancer patients. PMID: 23460839
    14. QSOX1 activity was required for incorporation of laminin into the extracellular matrix (ECM) synthesized by fibroblasts, and ECM produced without QSOX1 was defective in supporting cell-matrix adhesion. PMID: 23704371
    15. crystal structure PMID: 22801504
    16. These results propose for the first time possible roles for QSOX1 in atherosclerosis. PMID: 22069028
    17. Taken together, our results suggest that the mechanism of QSOX1-mediated tumor cell invasion is by activation of MMP-2 and MMP-9. PMID: 21989104
    18. Data suggested that the C449-C452 motif was essential for the activity of human QSOX 1b; the C70-C73 motif was fundamental in electron transfer from thiol-containing substrate including reduced proteins, DTT, GSH. PMID: 21148546
    19. A partial QSOX1 crystal structure reveals a single-chain pseudo-dimer mimicking the quaternary structure of Erv enzymes. PMID: 20211621
    20. In the plasma peptidome of patients with ductal adenocarcinoma of the pancreas (DAP), a prominent peptide was identified from the QSOX1 parent protein. This peptide was present in 16 of 23 DAP patients and 4 of 5 patients with IPMN. PMID: 19795908
    21. Data show that the longer version of human QSOX1 protein (hQSOX1a) is a transmembrane protein localized primarily to the Golgi apparatus, and that hQSOX1a can act in vivo as an oxidase. PMID: 17331072
    22. internal redox steps studied by mutagenesis PMID: 18393449

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform 1]: Golgi apparatus membrane; Single-pass membrane protein. Secreted.; [Isoform 2]: Secreted.
  • 蛋白家族:
    Quiescin-sulfhydryl oxidase (QSOX) family
  • 組織特異性:
    Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9756

    OMIM: 603120

    KEGG: hsa:5768

    STRING: 9606.ENSP00000356574

    UniGene: Hs.744925



主站蜘蛛池模板: 8x8ⅹ在线永久免费入口| 亚洲蜜芽在线精品一区| 国产亚洲婷婷香蕉久久精品| 亚洲欧洲免费无码| 亚洲精品无码一二区a片| 亚洲国产成人精品无码区二本| 欧洲精品一线二线三线区别| 美女视频黄是免费| 99re6热视频这里只精品首页| 久久久一本精品99久久精品66直播 | 亚洲精品久久久狠狠爱小说| 亚洲一区二区三区高清av| 国产精品激情欧美可乐视频| 成人免费无码不卡毛片视频| 国产偷窥熟女高潮精品视频| 色悠久久久久久久综合网伊人 | 亚洲日韩穿丝袜在线推荐| 成熟妇女性成熟满足视频| 日韩经典午夜福利发布| 日本丰满护士bbw| 国产美女视频免费观看网址| 狠狠色狠狠色综合网| 国产精品国产三级在线专区| 日韩激情无码免费毛片| 亚洲欧美日韩中字视频三区| 国产激情电影综合在线看| 亚洲中文字幕无码爆乳av| 九九久久精品国产av片国产| 国产成人亚洲综合精品| 又硬又粗进去好爽免费| 无码人妻丝袜在线视频| 欧美精品乱码99久久蜜桃| 波多老师无码av中字专区| 国产精品二区一区二区aⅴ污介绍| 国产成人精品一区二区在线小狼| 亚洲精品字幕| 国产精品自在线一区| 欧美性色黄大片手机版| 西西人体444www大胆无码视频| 双乳被一左一右吃着动态图| 久久久久99精品成人片|