在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

QPCT Antibody

  • 中文名稱:
    QPCT兔多克隆抗體
  • 貨號:
    CSB-PA019135LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: QPCT antibody at 2µg/ml
      Lane 1: Rat muscle tissue
      Lane 2: Rat adrenal gland tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 41, 36 kDa
      Observed band size: 41 kDa
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA019135LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) QPCT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    QPCT
  • 別名:
    5730422A13Rik antibody; EC antibody; GCT antibody; Glutaminyl cyclase antibody; Glutaminyl peptide cyclotransferase antibody; Glutaminyl tRNA cyclotransferase antibody; Glutaminyl-peptide cyclotransferase antibody; Glutaminyl-tRNA cyclotransferase antibody; Glutamyl cyclase antibody; QC antibody; qpct antibody; QPCT_HUMAN antibody; sQC antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Glutaminyl-peptide cyclotransferase protein (29-361AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,QPCT Antibody (CSB-PA019135LA01HU),的標記方式是Non-conjugated。對于QPCT Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA019135LB01HU QPCT Antibody, HRP conjugated ELISA
    FITC CSB-PA019135LC01HU QPCT Antibody, FITC conjugated
    Biotin CSB-PA019135LD01HU QPCT Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
  • 基因功能參考文獻:
    1. The addition of QC activity to core diagnostic CSF biomarkers may be of specific interest in clinical cases with discordant imaging and biochemical biomarker results. PMID: 28587659
    2. these findings demonstrate a significant association between common single nucleotide polymorphism within QPCT gene and schizophrenia risk in a Han Chinese population. PMID: 26572640
    3. the genetic risk of QPCT gene for schizophrenia also exists in the Han Chinese population. PMID: 26492838
    4. observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta formation PMID: 24164736
    5. this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia. PMID: 23207485
    6. Upregulation of QPCT expression is associated with thyroid carcinomas. PMID: 23183267
    7. This study presents a first comparison of two mammalian QCs (human and mouse) containing typical, conserved post-translational modifications. PMID: 21671571
    8. The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease. PMID: 21301857
    9. Upon binding to PBD150, a large loop movement in gQC allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions. PMID: 21288892
    10. This study demonstrated that glutaminyl cyclase expression and pE-Abeta formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease. PMID: 20383514
    11. Human isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC. PMID: 19804409
    12. Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure. PMID: 12196024
    13. human glutaminyl cyclase is a metal-dependent transferase PMID: 14522962
    14. Glutaminyl cyclase was expressed as a fully active 37 kDa enzyme with kcat/Km values of 14.3, 9.3, and 2.4 mM(-1)s(-1) for the substrates Gln-Gln, Gln-NH(2), and Gln-t-butyl ester, respectively PMID: 14680951
    15. Genetic variations in QPCT are important factors affecting the bone mineral density of adult women that contribute to susceptibility for osteoporosis. PMID: 15231017
    16. structure of human QC in free form and bound to a substrate and three imidazole-derived inhibitors PMID: 16135565
    17. Our results suggest that QPCT may be the QTL gene at chromosome 2p for spine BMD variation in the Chinese population PMID: 17687619
    18. combined steady-state enzyme kinetic and X-ray structural analyses of 11 single-mutation human QCs to investigate the roles of the H-bond network in catalysis PMID: 18072935
    19. The computations outline the important role of Trp329 in helping the substrate binding process and stabilizing the cyclization transition state. PMID: 18470930
    20. Golgi apparatus retention implies a "housekeeping" protein maturation machinery conducting glycosylation and pyroglutamyl formation. For these isoenzymes, apparently similar strategies evolved to retain the proteins in the Golgi complex. PMID: 18486145

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Glutaminyl-peptide cyclotransferase family
  • 數據庫鏈接:

    HGNC: 9753

    OMIM: 607065

    KEGG: hsa:25797

    STRING: 9606.ENSP00000344829

    UniGene: Hs.79033



主站蜘蛛池模板: 国产精品久久久一区二区三区| 亚洲人成网线在线播放| 国产色播av在线观看| 亚洲欧洲自拍拍偷综合| 亚洲精品无码久久久久秋霞| 亚洲一卡2卡3卡4卡精品| 亚洲精品天堂成人片av在线播放 | 国产精品久久久久久爽爽爽床戏| 免费国产精品视频在线| 中国真实偷乱视频| 国产色爱av资源综合区| 在线天堂中文在线资源网| 无码av天天av天天爽| 日本国产成人国产在线播放| 色综合视频一区二区三区44 | 色噜噜狠狠成人中文综合| 中国极品少妇videossexhd| 又大又黄又粗又爽的免费视频| 在线视频精品免费观看10| 亚洲欧美综合国产精品二区| 亚洲午夜未满十八勿入| 亚洲欧美日韩精品久久| 色欲av无码一区二区三区| 99视频国产精品免费观看| 亚洲中文字幕无码日韩精品| 国产精品白浆无码流出| 国产绳艺sm调教室论坛| 亚洲人成网线在线播放| 国产成人无码午夜视频在线播放 | 青青草国产成人99久久| 无套熟女av呻吟在线观看| 久久成人国产精品无码| 男女18禁啪啪无遮挡激烈网站 | 国产又爽又粗又猛的视频| 国产麻豆md传媒视频| 亚洲 丝袜 制服 欧美 另类 | 少妇久久久久久人妻无码| 中文字幕人妻丝袜二区| 午夜不卡久久精品无码免费| 国产精品福利视频萌白酱| 日韩免费无码视频一区二区三区|