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QDPR Antibody

  • 中文名稱(chēng):
    QDPR兔多克隆抗體
  • 貨號(hào):
    CSB-PA019133LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue
      All lanes: QDPR antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 26, 23 kDa
      Observed band size: 26 kDa
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA019133LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA019133LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng):
    Rabbit anti-Homo sapiens (Human) QDPR Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    QDPR
  • 別名:
    6,7 dihydropteridine reductase antibody; DHPR antibody; DHPR_HUMAN antibody; Dihydropteridine reductase antibody; HDHPR antibody; HPR antibody; PKU2 antibody; Qdpr antibody; Quinoid dihydropteridine reductase antibody; SDR33C1 antibody; Short chain dehydrogenase/reductase family 33C, member 1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Dihydropteridine reductase protein (2-244AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,QDPR Antibody (CSB-PA019133LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于QDPR Antibody,我們還提供其他標(biāo)記。見(jiàn)下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱(chēng) 應(yīng)用
    HRP CSB-PA019133LB01HU QDPR Antibody, HRP conjugated ELISA
    FITC CSB-PA019133LC01HU QDPR Antibody, FITC conjugated
    Biotin CSB-PA019133LD01HU QDPR Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
  • 基因功能參考文獻(xiàn):
    1. show for the first time statistically significant up regulation of iNOS in QDPR overexpressing astrocytes. Increased expression of iNOS associated with astrocyte pathology seen in many neurodegenerative disorders may have implications in autoimmune neurodegenerative disorders. PMID: 29355631
    2. Mutation of dihydropteridine reductase (QDPR) inhibited the regulation of TOR serine-threonine kinases (mTOR), suggesting that QDPR is a positive regulator of autophagy via suppressing mTOR signaling. PMID: 28633336
    3. The allele frequencies for the QDPR c.68G > A(0.3%) polymorphism is not a major cause of Parkinson's disease in the Maltese. PMID: 27613114
    4. The mutation spectrum of the QDPR gene is different in the Chinese population. Most mutations are related to severe phenotype. PMID: 25124972
    5. JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery PMID: 22020936
    6. the electrostatic regulatory interaction between the SPRY2 F loop residues (that bind to imperatoxin A) and the ASI/basic residues of RyR1 does not influence bi-directional DHPR-RyR1 signaling during skeletal EC coupling PMID: 21239886
    7. less than 30 microM H2O2 increase DHPR activities, whereas levels greater than 30 microM H2O2 deactivate the enzyme based on the oxidation of Met146 and Met151 in the sequence, consequently leading to disruption of the NADH-dependent enzyme active site. PMID: 15009710
    8. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953

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  • 相關(guān)疾病:
    Hyperphenylalaninemia, BH4-deficient, C (HPABH4C)
  • 蛋白家族:
    Short-chain dehydrogenases/reductases (SDR) family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9752

    OMIM: 261630

    KEGG: hsa:5860

    STRING: 9606.ENSP00000281243

    UniGene: Hs.75438



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