在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-RPA2 (S33) Antibody

  • 中文名稱:
    磷酸化-RPA2 (S33)兔多克隆抗體
  • 貨號:
    CSB-PA000656
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of MCF-7 cells using Phospho-RPA p32 (S33) Polyclonal Antibody
    • Western Blot analysis of MCF7 cells using Phospho-RPA p32 (S33) Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    60S acidic ribosomal protein P1 antibody; AA409079 antibody; AI325195 antibody; AU020965 antibody; ik:tdsubc_2g1 antibody; M(2)21C antibody; MGC137236 antibody; OTTHUMP00000004008 antibody; p32 antibody; p34 antibody; RCJMB04_6d17 replication protein A2; 32kDa antibody; REPA2 antibody; Replication factor A protein 2 antibody; Replication protein A 32 kDa subunit antibody; Replication protein A 32kDa subunit antibody; Replication protein A 34 kDa subunit antibody; Replication protein A antibody; Replication Protein A2 (32kDa) antibody; Replication protein A2 antibody; Replication protein A2; 32kDa antibody; RF-A protein 2 antibody; Rf-A2 antibody; RFA antibody; RFA2_HUMAN antibody; RP-A p32 antibody; RP-A p34 antibody; RP21C antibody; RPA 2 antibody; RPA 32 antibody; RPA antibody; Rpa2 antibody; RPA32 antibody; RPA34 antibody; RpLP1 antibody; RpP2 antibody; xx:tdsubc_2g1 antibody; zgc:109822 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human RPA p32 around the phosphorylation site of S33.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
  • 基因功能參考文獻:
    1. RPA, best known for its role in DNA replication and repair, recruits HIRA to promoters and enhancers and regulates deposition of newly synthesized H3.3 to these regulatory elements for gene regulation. PMID: 28107649
    2. Single point mutations in the RPA32 subunit of RPA that abolish interaction with RFWD3 also inhibit interstrand crossling repair, demonstrating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair. PMID: 28575657
    3. The authors show that Vpr can form a trimolecular complex with UNG2 and RPA32 and the positive effect of UNG2 and RPA32 on the reverse transcription process leading to optimal virus replication and dissemination between the primary target cells of HIV-1. PMID: 27068393
    4. RPA32 phosphorylation regulates replication arrest, recombination, late origin firing, and mitotic catastrophe PMID: 24819595
    5. Expression of mutant RPA2 or loss of PALB2 expression led to significant DNA damage after replication stress, a defect accentuated by poly-ADP (adenosine diphosphate) ribose polymerase inhibitors. PMID: 25113031
    6. Conserved motifs are required for RPA32 binding the the N-terminus of SMARCAL1. PMID: 24910198
    7. study reports the characterization of the RPA32C-SMARCAL1 interface at the molecular level; implications of results are discussed with respect to the recruitment of SMARCAL1 and other DNA damage response and repair proteins to stalled replication forks PMID: 24730652
    8. study concludes RPA2 expression is translationally regulated via internal ribosome entry site and by eIF3a and that this regulation is partly accountable for cellular response to DNA damage and survival. PMID: 23393223
    9. this study has explored the role of RPA32 phosphorylation at CDK and ATR sites and propose that phosphorylation of the RPA32 subunit is dispensable for checkpoint activation induced by replication stress with aphidicolin. PMID: 23047005
    10. 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2 PMID: 22684010
    11. Data show that the R88C variant impairs binding of the R88C variant impairs binding of uracil-DNA glycosylase UNG2 to replication protein A RPA2. PMID: 22521144
    12. Replication protein A1, replication protein A2, and cyclins D2 and D3 seem to have a parallel role in the promotion of cell cycle in astrocytic tumors being implicated in the malignant progression of these neoplasms. PMID: 21496876
    13. RPA2 up-regulation may be involved in the growth and/or survival of BRCA1 tumor cells and useful in immunohistochemical discrimination of triple-negative BRCA1 tumors. PMID: 21137066
    14. At the subunit level, 13 proteins out of 30 examined may interact with RPA2. PMID: 20679368
    15. data suggest that RPA2 hyperphosphorylation plays a critical role in maintenance of genomic stability and cell survival after a DNA replication block via promotion of homologus recombination PMID: 20130019
    16. Data suggest that PP4-mediated dephosphorylation of RPA2 is necessary for an efficient DNA-damage response. PMID: 20154705
    17. RPA32, critical for cell proliferation and maintenance of genome stability, are markedly down-regulated, Data hypothesized that their DNA-related functions could be partially limited in TRAIL-resistant HL-60 cells. PMID: 19834905
    18. Phosphorylation of the RPA2 subunit is observed after exposure of cells to ionizing radiation (IR) and other DNA-damaging agents, which implicates the modified protein in the regulation of DNA replication after DNA damage or in DNA repair. PMID: 11731442
    19. RPA2 binds to menin and has a role in multiple endocrine neoplasia PMID: 12509449
    20. C-terminal domain of hRPA32 subunit (RPA32C) facilitates initiation of SV40 replication. PMID: 15793585
    21. in response to UV-induced DNA damage, ATR rapidly phosphorylates RPA2, disrupting its association with replication centers in the S-phase and contributing to the inhibition of DNA replication PMID: 17035231
    22. Determination at single-nucleotide resolution the relative positions of the single-stranded DNA with interacting intrinsic tryptophans of RPA32. PMID: 17583916
    23. RPA phosphorylation facilitates chromosomal DNA repair. PMID: 17928296
    24. RPA32 is extensively phosphorylated after the induction of EBV lytic replication. Rad51 and RPA32 are necessary for the completion of EBV lytic infection. PMID: 19386720
    25. The N-terminus of RPA1 and phosphorylation of RPA2 regulate RPA interactions with the MRE11-RAD50-NBS1 (MRN) complex and are important in the response to DNA damage. PMID: 19586055
    26. mitotic phosphorylation of RPA2 starts at the onset of mitosis, and dephosphorylation occurs during late cytokinesis. PMID: 19671522

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus, PML body.
  • 蛋白家族:
    Replication factor A protein 2 family
  • 數據庫鏈接:

    HGNC: 10290

    OMIM: 179836

    KEGG: hsa:6118

    STRING: 9606.ENSP00000363021

    UniGene: Hs.79411



主站蜘蛛池模板: 精品高朝久久久久9999| 另类内射国产在线| 无人区码一码二码w358cc| 天天爽亚洲中文字幕| 最新 国产 精品 精品 视频 | 印度妓女野外xxww| 久久精品一区二区av999| 无码国产伦一区二区三区视频| 日韩人妻中文无码一区二区七区| 18禁真人抽搐一进一出在线| 天天爽夜夜爽人人爽88| 国产奶头好大揉着好爽视频| 亚洲色成人一区二区三区小说| 18禁亚洲深夜福利入口| 麻豆精品久久久久久中文字幕无码 | 日韩欧美群交p内射捆绑| 最新777第四色米奇影视| 麻豆传传媒久久久爱| 大肉大捧一进一出好爽app| 97国产揄拍国产精品人妻| 色欲综合久久躁天天躁| 无码人妻熟妇av又粗又大| 亚洲中文在线播放一区| 国产公开久久人人97超碰| 国产亚洲产品影市在线产品| 亚洲综合色自拍一区| 一本大道在线观看无码一区| 亚洲国产成人第一天堂| 99久久久无码国产精品6| 漂亮人妻熟睡中被公侵犯中文版 | 中文国产成人精品久久不卡| 99久久精品精品6精品精品| 日韩精品亚洲色大成网站| 中文无码一区二区三区在线观看| 免费无码国产v片在线观看| 国产精品亚洲а∨天堂网 | 免费毛片手机在线播放| 久久aⅴ人妻少妇嫩草影院| 中文字幕无线码免费人妻| 久久久噜噜噜久久熟女aa片| 四虎影库久免费视频|