在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-NFATC3 (S165) Antibody

  • 中文名稱:
    磷酸化-NFATC3 (S165)兔多克隆抗體
  • 貨號(hào):
    CSB-PA020080
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    C80703 antibody; cytoplasmic 3 antibody; D8Ertd281e antibody; NF AT4 antibody; NF ATc3 antibody; NF-AT4 antibody; NF-ATc3 antibody; NFAC3_HUMAN antibody; NFAT4 antibody; NFATc3 antibody; NFATx antibody; Nuclear factor of activated T cells, cytoplasmic 3 antibody; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 antibody; Nuclear factor of activated T-cells antibody; T cell transcription factor NFAT4 antibody; T-cell transcription factor NFAT4 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from Human NFATc3 around the phosphorylation site of S165.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. Along with NFATC4, involved in embryonic heart development.
  • 基因功能參考文獻(xiàn):
    1. MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRA PMID: 28627449
    2. The NFATc3 first induced the expression of its interaction partner FosB before forming the heterodimeric NFATc3-FosB transcription factor complex, which bound the proximal AP-1 site in the TF gene promoter and activated TF expression. PMID: 28724635
    3. we found that VIP inhibits NFAT nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP expression could be a protective compensatory mechanism PMID: 28125639
    4. the transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells. PMID: 27697837
    5. Calcineurin together with its upstream molecule, calpain 2, and its downstream effector, NFAT-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes. PMID: 27123462
    6. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis PMID: 25215946
    7. Suggest nuclear NF-AT3 and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-beta1 levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation. PMID: 25422138
    8. Microvesicles from tumor cells transferred TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activation of the transcription factor NFATc3 (nuclear factor of activated T cells isoform c3). PMID: 24582564
    9. AP-1 and NFAT4 complex promotes miR-23a expression. PMID: 23929433
    10. The closely related transcription factors NFAT1 and NFAT4 possess distinct nuclear localization dynamics in response to cell stimulation. PMID: 23219532
    11. Data indicate that NFATc3 undergoes rapid dephosphorylation and nuclear translocation that are essentially complete within 20 min, although NFATc4 remains phosphorylated and localized to the cytosol. PMID: 22977251
    12. Abeta-activated NFAT4 proteins were associated with astrocytic BACE1 gene expression via direct interaction with the BACE1 promoter region. PMID: 22846573
    13. The authors report that NFAT4 and NF-kappaB interact at the KB element to co-operatively activate both human polyomavirus JC early and late transcription and viral DNA replication. PMID: 22749879
    14. NFATc3 is specifically required for IL2 and cyclooxygenase-2 (COX2) gene expression in T cells and for T-cell proliferation and NFATc3 regulates COX2 in endothelial cells PMID: 21642596
    15. transactivation activity and role in inducing differentiation of CD4(+)CD8(+) T cells PMID: 11997392
    16. NFAT and thyroid transcription factor-1 have roles in regulating transcription of the surfactant protein D gene PMID: 15173172
    17. NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj PMID: 16260608
    18. We found that [Ca(2+)](i) oscillations were associated with NFAT translocation into the nucleus in undifferentiated hMSCs. As the hMSCs differentiated to adipocytes, the [Ca(2+)](i) oscillations disappeared and the translocation of NFAT ceased. PMID: 16445977
    19. Calcium signaling and the activation of NFAT in glial cells are required for JC Virus infection of the CNS. PMID: 17035332
    20. CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway PMID: 18815128

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
  • 組織特異性:
    Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, hear
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 7777

    OMIM: 602698

    KEGG: hsa:4775

    STRING: 9606.ENSP00000300659

    UniGene: Hs.436585



主站蜘蛛池模板: 欧美猛少妇色xxxxx猛叫| 久久成人国产精品| 欧洲吸奶大片在线看| 国自产拍偷拍精品啪啪模特| 国内精品伊人久久久久影院对白| 国产欧美日韩精品专区| 精品国产av一区二区三区| 99久久久无码国产精品性| 亚洲中文字幕在线第二页| 国产精品美女久久久m| 2020精品国产自在现线官网| 国内大量偷窥精品视频| 深夜福利啪啪片| 亚洲精品久久7777777国产| 无码加勒比一区二区三区四区 | 青青久在线视频免费观看| 天堂av男人在线播放| 少妇被爽到高潮在线观看| 怡红院一区二区三区在线| 亂倫近親相姦中文字幕| 欧美交a欧美精品喷水| 最新在线精品国产福利| 无限看片在线版免费视频大全| 国产精品你懂的在线播放| 免费人成在线观看视频无码| 麻豆精品久久久久久中文字幕无码| 无码h黄肉3d动漫在线观看| 护士的小嫩嫩好紧好爽| 亚洲精品无码乱码成人| 国产精品无码一区二区三区在| 精品少妇ay一区二区三区| 西西444www大胆无码视频| 亚洲成av人片在线观看下载| 国产精品精华液网站| 国产无夜激无码av毛片| 黑人大战欲求不满人妻| 国产又大又黑又粗免费视频| 在线无码中文字幕一区| 久久国产精品人妻丝袜| 成人无码视频| 乱中年女人伦av|