在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NFATC3 Antibody, HRP conjugated

  • 中文名稱:
    NFATC3兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA615540LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NFATC3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    C80703 antibody; cytoplasmic 3 antibody; D8Ertd281e antibody; NF AT4 antibody; NF ATc3 antibody; NF-AT4 antibody; NF-ATc3 antibody; NFAC3_HUMAN antibody; NFAT4 antibody; NFATc3 antibody; NFATx antibody; Nuclear factor of activated T cells, cytoplasmic 3 antibody; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 antibody; Nuclear factor of activated T-cells antibody; T cell transcription factor NFAT4 antibody; T-cell transcription factor NFAT4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Nuclear factor of activated T-cells, cytoplasmic 3 protein (887-1070AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. Along with NFATC4, involved in embryonic heart development.
  • 基因功能參考文獻:
    1. MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRA PMID: 28627449
    2. The NFATc3 first induced the expression of its interaction partner FosB before forming the heterodimeric NFATc3-FosB transcription factor complex, which bound the proximal AP-1 site in the TF gene promoter and activated TF expression. PMID: 28724635
    3. we found that VIP inhibits NFAT nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP expression could be a protective compensatory mechanism PMID: 28125639
    4. the transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells. PMID: 27697837
    5. Calcineurin together with its upstream molecule, calpain 2, and its downstream effector, NFAT-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes. PMID: 27123462
    6. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis PMID: 25215946
    7. Suggest nuclear NF-AT3 and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-beta1 levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation. PMID: 25422138
    8. Microvesicles from tumor cells transferred TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activation of the transcription factor NFATc3 (nuclear factor of activated T cells isoform c3). PMID: 24582564
    9. AP-1 and NFAT4 complex promotes miR-23a expression. PMID: 23929433
    10. The closely related transcription factors NFAT1 and NFAT4 possess distinct nuclear localization dynamics in response to cell stimulation. PMID: 23219532
    11. Data indicate that NFATc3 undergoes rapid dephosphorylation and nuclear translocation that are essentially complete within 20 min, although NFATc4 remains phosphorylated and localized to the cytosol. PMID: 22977251
    12. Abeta-activated NFAT4 proteins were associated with astrocytic BACE1 gene expression via direct interaction with the BACE1 promoter region. PMID: 22846573
    13. The authors report that NFAT4 and NF-kappaB interact at the KB element to co-operatively activate both human polyomavirus JC early and late transcription and viral DNA replication. PMID: 22749879
    14. NFATc3 is specifically required for IL2 and cyclooxygenase-2 (COX2) gene expression in T cells and for T-cell proliferation and NFATc3 regulates COX2 in endothelial cells PMID: 21642596
    15. transactivation activity and role in inducing differentiation of CD4(+)CD8(+) T cells PMID: 11997392
    16. NFAT and thyroid transcription factor-1 have roles in regulating transcription of the surfactant protein D gene PMID: 15173172
    17. NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj PMID: 16260608
    18. We found that [Ca(2+)](i) oscillations were associated with NFAT translocation into the nucleus in undifferentiated hMSCs. As the hMSCs differentiated to adipocytes, the [Ca(2+)](i) oscillations disappeared and the translocation of NFAT ceased. PMID: 16445977
    19. Calcium signaling and the activation of NFAT in glial cells are required for JC Virus infection of the CNS. PMID: 17035332
    20. CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway PMID: 18815128

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
  • 組織特異性:
    Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, hear
  • 數據庫鏈接:

    HGNC: 7777

    OMIM: 602698

    KEGG: hsa:4775

    STRING: 9606.ENSP00000300659

    UniGene: Hs.436585



主站蜘蛛池模板: 尤物色综合欧美五月俺也去 | 欧美日韩无套内射另类| 六十熟妇乱子伦视频| 国产99视频精品免费视频6| 丰满的少妇被猛烈进入白浆 | 亚洲精品综合一区二区三| 日本黄漫动漫在线观看视频| 国产欧美另类久久久精品不卡| 欧美怡红院免费全部视频| 999国产精品999久久久久久| 成年女人免费v片| 最新亚洲伦理中文字幕| 日本xxxx裸体xxxx视频大全| 妺妺窝人体色www婷婷| 高清无码一区二区在线观看吞精| 欧美色欧美亚洲日韩在线播放| 亚洲乱码在线卡一卡二卡新区| 老熟女乱子伦| 亚洲国产成人久久综合碰| 果冻传媒2021精品一区| 精品国产自在现线电影| 青青草视频在线观看| 国产 在线 | 日韩| 中文字幕日产熟女乱码| 亚洲国产成人综合在线不卡 | 亚洲午夜成人片| 2018av天堂在线视频精品观看| 成人免费b2b网站大全在线| 久久国产偷任你爽任你| 999久久久免费精品国产| 欧美s码亚洲码精品m码| 日韩精品一区二区三区中文| 免费夫妻生活片av| 免费观看男女性高视频| 人妻熟女一区二区aⅴ千叶宁真| 精品一区精品二区制服| 8x福利精品第一导航| 亚洲国产精品无码专区成人| 欧美变态口味重另类在线视频 | 精品国产av色一区二区深夜久久| 亚洲国产欧美在线人成人|