在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-NEK9 (T210) Antibody

  • 中文名稱:
    磷酸化-NEK9 (T210)兔多克隆抗體
  • 貨號:
    CSB-PA070248
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    KIAA1995 antibody; APUG antibody; DKFZp434D0935 antibody; LCCS10 antibody; MGC138306 antibody; MGC16714 antibody; NC antibody; NEK 9 antibody; Nek8 antibody; nek9 antibody; NEK9_HUMAN antibody; Nercc 1 kinase antibody; NERCC antibody; NERCC1 antibody; Nercc1 kinase antibody; Never in mitosis A related kinase 9 antibody; Never in mitosis A-related kinase 9 antibody; NIMA (never in mitosis gene a) related kinase 9 antibody; NIMA related kinase 8 antibody; NIMA related kinase 9 antibody; NIMA related kinase Nek8 antibody; NimA related protein kinase 9 antibody; NIMA-related kinase 8 antibody; NimA-related protein kinase 9 antibody; Serine/threonine protein kinase Nek9 antibody; Serine/threonine-protein kinase Nek9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human Nek9 around the phosphorylation site of T210.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
  • 基因功能參考文獻:
    1. High expression level of NEK9 is associated with recurrence in glioblastoma. PMID: 26956052
    2. Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis. PMID: 28630147
    3. Recessive NEK9 mutation is associated with lethal skeletal dysplasia. PMID: 26908619
    4. Somatic Mutations in NEK9 Cause Nevus Comedonicus. PMID: 27153399
    5. Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 target gene expression. PMID: 26676776
    6. The C-terminal domain of Nek9 activates Nek7 through promoting back-to-back dimerization. PMID: 26522158
    7. The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53. PMID: 25131192
    8. NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint control. PMID: 23665325
    9. Structural analysis of LC8 with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 upon phosphorylation on Ser(944) within the Nek9 sequence PMID: 23482567
    10. Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells. PMID: 22818914
    11. The interaction between the human NimA-like protein kinase Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance. PMID: 21735226
    12. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. PMID: 21642957
    13. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. PMID: 21454704
    14. binds the Ran GTPase and regulates mitotic progression PMID: 12101123
    15. Activated in mitosis, and activates nek6 and nek7 kinase. PMID: 12840024
    16. mediates certain cellular processes, which are ultimately essential for interphase progression PMID: 14660563
    17. The disruption of a nuclear function of NEK9 by adenovirus E1A-associated cellular proteins is reported. PMID: 17443675
    18. The activity of Nek6 and Nek7, but not the tyrosine mutant, is increased by interaction with the Nek9 noncatalytic C-terminal domain, suggesting a mechanism in which the tyrosine is released from its autoinhibitory position. PMID: 19941817

    顯示更多

    收起更多

  • 相關疾病:
    Lethal congenital contracture syndrome 10 (LCCS10); Nevus comedonicus (NC); Arthrogryposis, Perthes disease, and upward gaze palsy (APUG)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 組織特異性:
    Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.
  • 數據庫鏈接:

    HGNC: 18591

    OMIM: 609798

    KEGG: hsa:91754

    STRING: 9606.ENSP00000238616

    UniGene: Hs.624721



主站蜘蛛池模板: 黑人玩弄人妻1区二区| 色五月激情五月| 人妻熟女一区二区aⅴ向井蓝| 国产成人无码免费视频在线| 久久人妻国产精品| 国产精品爽爽va吃奶在线观看| 色婷婷欧美在线播放内射| 少妇放荡的呻吟干柴烈火动漫| 免费无码av片在线观看国产| 色欲综合久久中文字幕网| 制服丝袜中文字幕在线| 久久久精品人妻一区二区三区| 动漫av永久无码精品每日更新| 亚洲精品无码专区在线播放| 51久久国产露脸精品国产| 无码免费一区二区三区免费播放| 无码中文人妻在线一区| 中文字幕制服丝袜人妻动态图| 国产精品无码久久av| 亚洲精品无码av专区最新| 国产午精品午夜福利757视频播放| 日本丶国产丶欧美色综合| 扒开双腿吃奶呻吟做受视频 | 丰满爆乳在线播放| 亚洲欧洲精品无码av| 色婷婷综合缴情综免费观看| 精品人妻无码专区中文字幕| 婷婷五月深爱综合开心网| 亚洲蜜芽在线精品一区| 无码丰满熟妇| 久久久精品久久久久久96| 激烈的性高湖波多野结衣| 亚洲国产精品自产在线播放| 无码人妻丰满熟妇区五十路| 伊人久久大香线蕉综合5g| 国产精品乱码高清在线观看| 久久精品国产99久久久古代| 日本熟妇乱人伦xxxx| 在线天堂资源www| 久久久久久九九99精品 | 欧美老熟妇牲交|