在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Serine/threonine-protein kinase Nek9 (NEK9), partial

Recombinant Human Serine/threonine-protein kinase Nek9 (NEK9), partial

  • 中文名稱：
    人NEK9重組蛋白
  • 貨號：
    CSB-YP837435HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NEK9重組蛋白
  • 貨號：
    CSB-EP837435HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NEK9重組蛋白
  • 貨號：
    CSB-BP837435HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NEK9重組蛋白
  • 貨號：
    CSB-MP837435HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    KIAA1995; APUG; DKFZp434D0935; LCCS10; MGC138306; MGC16714; NC; NEK 9; Nek8; nek9; NEK9_HUMAN; Nercc 1 kinase; NERCC; NERCC1; Nercc1 kinase; Never in mitosis A related kinase 9; Never in mitosis A-related kinase 9; NIMA (never in mitosis gene a) related kinase 9; NIMA related kinase 8; NIMA related kinase 9; NIMA related kinase Nek8 ; NimA related protein kinase 9; NIMA-related kinase 8; NimA-related protein kinase 9; Serine/threonine protein kinase Nek9 ; Serine/threonine-protein kinase Nek9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
  • 基因功能參考文獻：
    1. High expression level of NEK9 is associated with recurrence in glioblastoma. PMID: 26956052
    2. Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis. PMID: 28630147
    3. Recessive NEK9 mutation is associated with lethal skeletal dysplasia. PMID: 26908619
    4. Somatic Mutations in NEK9 Cause Nevus Comedonicus. PMID: 27153399
    5. Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 target gene expression. PMID: 26676776
    6. The C-terminal domain of Nek9 activates Nek7 through promoting back-to-back dimerization. PMID: 26522158
    7. The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53. PMID: 25131192
    8. NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint control. PMID: 23665325
    9. Structural analysis of LC8 with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 upon phosphorylation on Ser(944) within the Nek9 sequence PMID: 23482567
    10. Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells. PMID: 22818914
    11. The interaction between the human NimA-like protein kinase Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance. PMID: 21735226
    12. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. PMID: 21642957
    13. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. PMID: 21454704
    14. binds the Ran GTPase and regulates mitotic progression PMID: 12101123
    15. Activated in mitosis, and activates nek6 and nek7 kinase. PMID: 12840024
    16. mediates certain cellular processes, which are ultimately essential for interphase progression PMID: 14660563
    17. The disruption of a nuclear function of NEK9 by adenovirus E1A-associated cellular proteins is reported. PMID: 17443675
    18. The activity of Nek6 and Nek7, but not the tyrosine mutant, is increased by interaction with the Nek9 noncatalytic C-terminal domain, suggesting a mechanism in which the tyrosine is released from its autoinhibitory position. PMID: 19941817

    顯示更多

    收起更多

  • 相關疾病：
    Lethal congenital contracture syndrome 10 (LCCS10); Nevus comedonicus (NC); Arthrogryposis, Perthes disease, and upward gaze palsy (APUG)
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 組織特異性：
    Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.
  • 數據庫鏈接：

    HGNC: 18591

    OMIM: 609798

    KEGG: hsa:91754

    STRING: 9606.ENSP00000238616

    UniGene: Hs.624721



主站蜘蛛池模板： 欧洲黑大粗无码免费| 久久久久人妻精品一区三寸| 人牛交vide欧美xxxx| 国产超碰人人做人人爽av动图| 性暴力欧美猛交在线播放| 少妇太爽了在线观看| 久久精品国产99国产精偷| 久久香蕉国产线看观看亚洲小说| 国产福利永久在线视频无毒不卡| 欧美丰满老熟妇aaaa片| 香蕉久久一区二区三区啪啪| 伦理片午夜视频在线观看| 成人网站国产在线视频内射视频| 精品国产亚洲一区二区三区| 国产精品欧美一区二区三区| 99久热re在线精品视频| 亚洲国产成人第一天堂| 在线观看特色大片免费网站| 婷婷四房综合激情五月在线| 亚洲精品久久66国产高清| 男女18禁啪啪无遮挡| 国产女人的高潮国语对白| 国产精品国产自线拍免费不卡| 日韩 高清 无码 人妻| 亚洲女同一区二区| 国产99久久久久久免费看| 最近中文字幕免费mv在线视频| 国产熟妇乱子伦视频在线观看| 怡红院a∨人人爰人人爽| 香蕉在线精品视频在线| 国产三级视频在线播放线观看| 男女性高爱潮免费网站| 国产欧美精品一区二区三区-老狼| 成人亚洲欧美久久久久| 国产精品二区一区二区aⅴ污介绍| 亚洲精品亚洲人成人网| 天堂官网在线资源网| 久久精品超碰av无码| 精品久久久久久久久久久aⅴ| 欧洲日韩亚洲无线在码| 国产成人8x人网站在线视频|