在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-EPS15 (Y849) Antibody

Phospho-EPS15 (Y849) Antibody

  • 中文名稱：
    磷酸化-EPS15 (Y849)兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008076
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of JK cells using Phospho-Eps15 (Y849) Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    EPS15 antibody; AF1PEpidermal growth factor receptor substrate 15 antibody; Protein Eps15 antibody; Protein AF-1p antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Eps15 around the phosphorylation site of Y849.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
  • 基因功能參考文獻(xiàn)：
    1. Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement. PMID: 27237791
    2. An interaction of Eps15 and pS227-FIP2 at the appropriate time and location in polarizing cells is necessary for proper establishment of epithelial polarity. PMID: 28228550
    3. RAB11FIP3 combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor. PMID: 28215104
    4. Together, the data indicate that a CUL3-SPOPL E3 ubiquitin ligase complex regulates endocytic trafficking and formation of multivesicular bodies by ubiquitinating and degrading EPS15 at endosomes. PMID: 27008177
    5. identify USP9X as a novel regulator of EGFR endocytosis PMID: 26748853
    6. over-expression of EPS15 is a potential favorable prognostic marker in breast cancer. PMID: 26289382
    7. MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins are associated with acute lymphoblastic leukemia. PMID: 22581003
    8. Ubiquitin is sufficient for Eps15 recruitment to endosomes. PMID: 25260758
    9. analysis of the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners PMID: 20106972
    10. parkin Ubld uses differential surfaces to recruit UIM regions from the S5a proteasomal subunit compared with Eps15 involved in cell signaling. PMID: 19875440
    11. Eps15 regulates clathrin coat assembly in vivo, and interactions between Eps15 homology domains and NPF motifs are involved in clathrin-coated vesicle formation during synaptic vesicle recycling PMID: 12807910
    12. JC virus binding to human glial cells induces an intracellular signal that is critical for entry and infection by a ligand-inducible clathrin and eps15-dependent mechanism. PMID: 14671106
    13. However, GFP-EH21 (a mutant Eps15) expression caused a 50% reduction in released enveloped virions, decreased formation of satellite plaques, and delayed virus spread, indicating an important role for receptor-mediated endocytosis. PMID: 15767409
    14. Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome. PMID: 16036216
    15. Data show that the first ubiquitin-interacting motif of Eps15 (UIM1) interacts directly with the UBL domain of ubiquilin, whereas it does not bind to ubiquitinated proteins. PMID: 16159959
    16. SGIP1alpha plays an essential role in clathrin-mediated endocytosis by interacting with phospholipids and Eps15. PMID: 17626015
    17. These results indicate that Eps15b is an endosomally localized isoform of Eps15 that is present in the Hrs complex via direct Hrs interaction and important for the sorting function of this complex. PMID: 18362181
    18. EPS15 and EPS15R mediated internalization of activated EGF receptor to result in receptor recycling as to reinforce the proliferative response to EGF. PMID: 18395097
    19. Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase. PMID: 19109251

    顯示更多

    收起更多

  • 相關(guān)疾病：
    A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein.
  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit.; [Isoform 2]: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3419

    OMIM: 600051

    KEGG: hsa:2060

    STRING: 9606.ENSP00000360798

    UniGene: Hs.83722



主站蜘蛛池模板： 亚洲综合在线视频自拍| 性一交一乱一伦一色一情孩交| 日日噜噜噜夜夜爽爽狠狠| 人妻无码一区二区三区av| 综合激情久久综合激情| 四虎永久地址www成人久久| 毛片免费视频在线观看| 3d动漫精品啪啪一区二区| 女人被躁到高潮免费视频 | 中文字幕日产乱码国内自| 中文字幕人妻互换av久久| 国产久热精品无码激情 | 好硬好湿好爽再深一点动态图视频| wwww亚洲熟妇久久久久| 亚洲国产精品成人天堂| 亚洲αv无码一区二区三区四区| 日本一区二区无卡高清视频| 可以免费观看的av毛片下载| 少妇人妻互换不带套| 超碰97人人做人人爱亚洲| 久久国产乱子精品免费女| 女人扒开屁股爽桶30分钟| 任我撸在线视频| 国产99久久亚洲综合精品西瓜tv| 中文字幕在线不卡精品视频99| 少妇粉嫩小泬白浆流出| 国产精品高潮呻吟av久久4虎| 2020年无码国产精品高清免费| 国产精品久久久久久52avav| 国产精品美女一区二区视频| 人妻人人澡人人添人人爽人人玩| 国产精品无码a∨麻豆| 久久久久无码国产精品一区| 男女又色又爽又爽视频| 先锋影音av资源站av| 强行无套内谢大学生初次 | 天堂а√在线官网| 日韩卡二卡三卡四卡永久入口 | 亚洲日韩欧洲乱码av夜夜摸| 国内精品久久久久影院薰衣草| 国产成人a∨麻豆精品|