在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-EPS15 (Tyr849) Antibody

Phospho-EPS15 (Tyr849) Antibody

  • 中文名稱：
    磷酸化-EPS15 (Tyr849)兔多克隆抗體
  • 貨號：
    CSB-PA190074
  • 規格：
    ￥2454
  • 圖片：
    • Western blot analysis of extracts from JK cells (Lane 2), using EPS15 (Phospho-Tyr849) Antibody. The lane on the left is treated with antigen-specific peptide.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) EPS15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of tyrosine 849 (S-A-Y(p)-P-S) derived from Human Ephrin EPS15.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
  • 基因功能參考文獻：
    1. Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement. PMID: 27237791
    2. An interaction of Eps15 and pS227-FIP2 at the appropriate time and location in polarizing cells is necessary for proper establishment of epithelial polarity. PMID: 28228550
    3. RAB11FIP3 combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor. PMID: 28215104
    4. Together, the data indicate that a CUL3-SPOPL E3 ubiquitin ligase complex regulates endocytic trafficking and formation of multivesicular bodies by ubiquitinating and degrading EPS15 at endosomes. PMID: 27008177
    5. identify USP9X as a novel regulator of EGFR endocytosis PMID: 26748853
    6. over-expression of EPS15 is a potential favorable prognostic marker in breast cancer. PMID: 26289382
    7. MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins are associated with acute lymphoblastic leukemia. PMID: 22581003
    8. Ubiquitin is sufficient for Eps15 recruitment to endosomes. PMID: 25260758
    9. analysis of the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners PMID: 20106972
    10. parkin Ubld uses differential surfaces to recruit UIM regions from the S5a proteasomal subunit compared with Eps15 involved in cell signaling. PMID: 19875440
    11. Eps15 regulates clathrin coat assembly in vivo, and interactions between Eps15 homology domains and NPF motifs are involved in clathrin-coated vesicle formation during synaptic vesicle recycling PMID: 12807910
    12. JC virus binding to human glial cells induces an intracellular signal that is critical for entry and infection by a ligand-inducible clathrin and eps15-dependent mechanism. PMID: 14671106
    13. However, GFP-EH21 (a mutant Eps15) expression caused a 50% reduction in released enveloped virions, decreased formation of satellite plaques, and delayed virus spread, indicating an important role for receptor-mediated endocytosis. PMID: 15767409
    14. Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome. PMID: 16036216
    15. Data show that the first ubiquitin-interacting motif of Eps15 (UIM1) interacts directly with the UBL domain of ubiquilin, whereas it does not bind to ubiquitinated proteins. PMID: 16159959
    16. SGIP1alpha plays an essential role in clathrin-mediated endocytosis by interacting with phospholipids and Eps15. PMID: 17626015
    17. These results indicate that Eps15b is an endosomally localized isoform of Eps15 that is present in the Hrs complex via direct Hrs interaction and important for the sorting function of this complex. PMID: 18362181
    18. EPS15 and EPS15R mediated internalization of activated EGF receptor to result in receptor recycling as to reinforce the proliferative response to EGF. PMID: 18395097
    19. Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase. PMID: 19109251

    顯示更多

    收起更多

  • 相關疾病：
    A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein.
  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit.; [Isoform 2]: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 3419

    OMIM: 600051

    KEGG: hsa:2060

    STRING: 9606.ENSP00000360798

    UniGene: Hs.83722



主站蜘蛛池模板： 久久精品国产一区二区电影 | а√天堂8资源中文在线| 成在人线av无码免费高潮水老板| 国产免费又色又爽又黄软件| 伊人久久大香线蕉影院| 日韩人妻精品无码一区二区三区| 宅宅少妇无码| 在线观看的网站| 欧美日韩国产亚洲沙发| 中文字幕日产乱码国内自| 久久久久久久精品成人热色戒汤唯| 黑人巨茎美女高潮视频| 18禁止进入1000部高潮网站| 女人扒下裤让男人桶到爽| 亚洲精品揄拍自拍首页一| av免费网址在线观看| 亚洲日韩在线中文字幕线路2区| 久久精品网站免费观看| 亚洲乱码伦小说区| 国产成人av无码精品| 成在人线av无码免观看午夜网| 国产线观看免费观看| 美女露出粉嫩小奶头在视频18禁 | 丰满多毛的大隂户毛茸茸| 亚洲高请码在线精品av| 国产v在线最新观看视频| 精品国产亚洲一区二区三区| 无码国产精品一区二区免费虚拟vr| 国产精品_国产精品_k频道| 免费观看日本污污ww网站| 日韩av高清在线看片| 国产成人av免费观看| 无码中文字幕人妻在线一区二区三区| 夜夜香夜夜摸夜夜添视频| 国产亚洲精品久久久久蜜臀| 丰满饥渴老女人hd| 精品服丝袜无码视频一区 | 波多野结衣爽到高潮大喷| 久热这里只有精品12| 久久国语露脸国产精品电影| 亚洲国产精品无码专区|