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Phospho-ELK3 (S357) Antibody

  • 中文名稱:
    磷酸化-ELK3 (S357)兔多克隆抗體
  • 貨號:
    CSB-PA008025
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO cells using Phospho-Net (S357) Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ELK3 antibody; ELK3; ETS domain protein (SRF accessory protein 2) antibody; ELK3_HUMAN antibody; ERP antibody; ETS domain protein antibody; ETS domain-containing protein Elk-3 antibody; ETS related protein ERP antibody; ETS related protein NET antibody; ETS-related protein ERP antibody; ETS-related protein NET antibody; NET antibody; SAP 2 antibody; SAP-2 antibody; SAP2 antibody; Serum response factor accessory protein 2 antibody; SRF accessory protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Monkey
  • 免疫原:
    Synthesized peptide derived from Human Net around the phosphorylation site of S357.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
  • 基因功能參考文獻:
    1. Decreased Net expression characterize on-small-cell lung cancer progression. PMID: 19483189
    2. Net might play an important role in pancreatic carcinogenesis PMID: 23469073
    3. These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells PMID: 27556500
    4. The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues. PMID: 27538444
    5. We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics. PMID: 27301639
    6. Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression. PMID: 28188790
    7. High expression of ELK3 is associated with migration and invasion of liver cancer stem cells. PMID: 27959451
    8. results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression PMID: 26637400
    9. The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PMID: 25401928
    10. ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function. PMID: 24719561
    11. Net and HIF1alpha are components of distinct signaling pathways that are intricately linked PMID: 20427288
    12. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID: 18316589
    13. These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer. PMID: 18832796

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  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    ETS family
  • 數據庫鏈接:

    HGNC: 3325

    OMIM: 600247

    KEGG: hsa:2004

    STRING: 9606.ENSP00000228741

    UniGene: Hs.46523



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