在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-ELK3 (S357) Antibody

  • 中文名稱:
    磷酸化-ELK3 (S357)兔多克隆抗體
  • 貨號:
    CSB-PA008025
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO cells using Phospho-Net (S357) Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ELK3 antibody; ELK3; ETS domain protein (SRF accessory protein 2) antibody; ELK3_HUMAN antibody; ERP antibody; ETS domain protein antibody; ETS domain-containing protein Elk-3 antibody; ETS related protein ERP antibody; ETS related protein NET antibody; ETS-related protein ERP antibody; ETS-related protein NET antibody; NET antibody; SAP 2 antibody; SAP-2 antibody; SAP2 antibody; Serum response factor accessory protein 2 antibody; SRF accessory protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Monkey
  • 免疫原:
    Synthesized peptide derived from Human Net around the phosphorylation site of S357.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
  • 基因功能參考文獻:
    1. Decreased Net expression characterize on-small-cell lung cancer progression. PMID: 19483189
    2. Net might play an important role in pancreatic carcinogenesis PMID: 23469073
    3. These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells PMID: 27556500
    4. The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues. PMID: 27538444
    5. We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics. PMID: 27301639
    6. Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression. PMID: 28188790
    7. High expression of ELK3 is associated with migration and invasion of liver cancer stem cells. PMID: 27959451
    8. results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression PMID: 26637400
    9. The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PMID: 25401928
    10. ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function. PMID: 24719561
    11. Net and HIF1alpha are components of distinct signaling pathways that are intricately linked PMID: 20427288
    12. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID: 18316589
    13. These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer. PMID: 18832796

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    ETS family
  • 數據庫鏈接:

    HGNC: 3325

    OMIM: 600247

    KEGG: hsa:2004

    STRING: 9606.ENSP00000228741

    UniGene: Hs.46523



主站蜘蛛池模板: 精品国产福利在线视频| 国产精品无码久久久久| 国産精品久久久久久久| 成人综合网站| 啊轻点内射在线视频| 99热网址最新获取域名| 国产人与zoxxxx另类| 在线日韩日本国产亚洲| 特级做a爰片毛片免费看无码| 美女被啪到深处抽搐视频| 亚洲2022国产成人精品无码区| 国产成人一区二区三区app| 中文字幕亚洲精品乱码| 巨爆乳无码视频在线观看| 国产亚洲精品久久77777| 狼群社区www中文视频| 风韵丰满熟妇啪啪区老熟熟女| 日本二区三区欧美亚洲国产| 亚洲美女高清无水av| av在线播放日韩亚洲欧| 亚洲精品毛片一区二区三区| 亚洲精品高清无码视频| 无码日本精品xxxxxxxxx| 午夜无码片在线观看影院y| 国产在线拍揄自揄拍无码视频| 亚洲精品无码永久在线观看性色| 日本孕妇潮喷高潮视频| 色婷婷亚洲精品综合影院| 中国女人高潮hd| 国产免费一区二区三区免费视频 | 无码三级中文字幕在线观看| 人妻av中文字幕久久| 国产97在线 | 日韩| 国产成人精品视觉盛宴| 夜夜高潮夜夜爽夜夜爱爱一区 | 久久国产精品久久精品国产| 97色偷偷色噜噜狠狠爱网站97 | 香港三日本三级少妇三级66| 亚洲国产成人av人片久久| 97国产在线看片免费人成视频| 精品国内在视频线2019|