在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ELK3 Antibody

  • 中文名稱:
    ELK3兔多克隆抗體
  • 貨號:
    CSB-PA008026
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ELK3 antibody; ELK3; ETS domain protein (SRF accessory protein 2) antibody; ELK3_HUMAN antibody; ERP antibody; ETS domain protein antibody; ETS domain-containing protein Elk-3 antibody; ETS related protein ERP antibody; ETS related protein NET antibody; ETS-related protein ERP antibody; ETS-related protein NET antibody; NET antibody; SAP 2 antibody; SAP-2 antibody; SAP2 antibody; Serum response factor accessory protein 2 antibody; SRF accessory protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from Human Net around the non-phosphorylation site of S357.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
  • 基因功能參考文獻:
    1. Decreased Net expression characterize on-small-cell lung cancer progression. PMID: 19483189
    2. Net might play an important role in pancreatic carcinogenesis PMID: 23469073
    3. These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells PMID: 27556500
    4. The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues. PMID: 27538444
    5. We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics. PMID: 27301639
    6. Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression. PMID: 28188790
    7. High expression of ELK3 is associated with migration and invasion of liver cancer stem cells. PMID: 27959451
    8. results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression PMID: 26637400
    9. The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PMID: 25401928
    10. ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function. PMID: 24719561
    11. Net and HIF1alpha are components of distinct signaling pathways that are intricately linked PMID: 20427288
    12. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID: 18316589
    13. These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer. PMID: 18832796

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    ETS family
  • 數據庫鏈接:

    HGNC: 3325

    OMIM: 600247

    KEGG: hsa:2004

    STRING: 9606.ENSP00000228741

    UniGene: Hs.46523



主站蜘蛛池模板: 男女无遮挡猛进猛出免费观看视频| 亚洲色欲色欱www在线| 无码av大香线蕉| av无码一区二区大桥久未| 极品无码av国模在线观看 | 无码国产玉足脚交极品网站 | 艳妇荡女欲乱双飞两中年熟妇| 永久黄网站色视频免费| 中国女人大白屁股ass| 亚洲日韩va在线视频| 中文字幕乱码熟妇五十中出色欲| 国产av丝袜旗袍无码网站| 成人免费看吃奶视频网站| 菠萝菠萝蜜午夜视频在线播放观看 | 蜜臀av在线无码国产| 亚洲成l人在线观看线路| 天堂资源最新在线| 在线播放国产一区二区三区| 国产一区二区野外| 人妻无码手机在线中文| 亚洲精品无播放器在线播放| 国产人妻精品一区二区三区| 亚洲精品色无码av试看| 中文字幕精品久久久久人妻红杏| 国产又黄又爽又色的免费视频| 久久精品黄aa片一区二区三区| 国产97公开成人免费视频在线观看 | 中文字幕亚洲乱码熟女一区二区| 女人夜夜春高潮爽a∨片传媒| 久久亚洲熟女cc98cm| 男人扒女人添高潮视频| 久久一本久综合久久爱| 亚洲精品美女久久777777| 少妇太爽了在线观看| 国产高清亚洲精品视bt天堂频| 亚洲在av极品无码| 老色鬼在线精品视频| 人妻熟女一二三区夜夜爱| 亚洲中文有码字幕青青| 好男人社区www在线观看| 日本大片免a费观看视频三区|