在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-CCNC (Ser275) Antibody

Phospho-CCNC (Ser275) Antibody

  • 中文名稱：
    磷酸化-CCNC (Ser275)兔多克隆抗體
  • 貨號：
    CSB-PA220960
  • 規格：
    ￥2454
  • 圖片：
    • Western blot analysis of extracts from 3T3 cells (Lane 2), A549 cells (Lane 3) and Hela cells (Lane 4), using Cyclin C (Phospho-Ser275) Antibody. The lane on the left is treated with antigen-specific peptide.
    • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cyclin C (Phospho-Ser275) antibody (left)or the same antibody preincubated with blocking peptide (right).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CCNC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CCNC
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of Serine 275(N-G-S(p)-A-N) derived from Human Cyclin C.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:1000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • 基因功能參考文獻：
    1. our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression. PMID: 26042770
    2. results suggest that CCNC temporarily protects SRC-2 against degradation and this event is involved in the transcriptional regulation of SRC-2 cell cycle target genes. PMID: 25986860
    3. Cancer-mediated CDK8 point mutations (D173A and D189N) change the binding pattern of cdk8 to its partner, CycC. PMID: 24754906
    4. cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation PMID: 25344755
    5. analysis of the structure-kinetic relationship of the cyclin-dependent kinase 8 (CDK8)/cyclin C (CycC) complex PMID: 23630251
    6. 2.2-A crystal structure of CDK8/CycC in complex with sorafenib; CDK8 structure reveals a unique CycC recognition helix that explains the specificity of the CDK8/CycC pair and discrimination among the highly promiscuous binding in the CDK/cyclin family PMID: 21806996
    7. Studies establish cyclin C as a critical regulator of the G(0)/G(1) transition of human HSPCs and suggest that modulating cyclin C levels may be useful for HSC expansion and more efficient engraftment. PMID: 19967789
    8. The present observations suggest different cellular functions of cyclin C in neurons and astrocytes in alzheimer's disease. PMID: 12600719
    9. A cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently. PMID: 15084261
    10. Identification of multiple 1alpha,25(OH)2D3 response elements in the cyclin C promoter. PMID: 15863722
    11. Physical chromosome mapping of the deleted region of chromosome 6 suggests that CCNC is a candidate tumor suppressor gene. PMID: 17089020
    12. C2 isoform may play a presently unexplored and important role in mammalian testis and probably this isoform is the one that is mainly implicated in cell cycle regulation. PMID: 17385550
    13. Data suggests that the primary regulation of Cyclin C by all-trans RA and Forskolin mediates some of the cell cycle control actions of these compounds. PMID: 19683536

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Cyclin family, Cyclin C subfamily
  • 組織特異性：
    Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • 數據庫鏈接：

    HGNC: 1581

    OMIM: 123838

    KEGG: hsa:892

    STRING: 9606.ENSP00000428982

    UniGene: Hs.430646



主站蜘蛛池模板： 欧美日韩亚洲国产欧美电影 | 色综合久久88色综合天天| 天堂8在线新版官网| 国产精品久久久久久超碰| 色哟哟精品视频在线观看| 吃奶揉捏奶头高潮视频| 天堂va视频一区二区| 久久天天躁夜夜躁狠狠综合| 2020国产精品永久在线| 国产男生午夜福利免费网站| 日韩精品久久久肉伦网站| 放荡的美妇在线播放| 色哟哟国产精品免费观看| 好男人www社区| 人妻久久久一区二区三区 | 日本精品aⅴ一区二区三区| 亚洲国产美女久久久久| 免费人成在线观看网站品爱网| 国产无遮挡免费真人视频在线观看| 日本成本人三级在线观看| 末发育女av片一区二区| 国产av中文av无码av狼人| 亚洲欧洲av一区二区久久| 亚洲国产午夜精华无码福利| 无遮挡激情视频国产在线观看| 亚洲精品国产福利一区二区| 人人玩人人添人人澡超碰偷拍| 97夜夜澡人人爽人人喊a| 麻豆亚洲国产成人精品无码区 | 免费啪视频在线观看视频日本| 99热久久这里只精品国产www| 日本亚洲欧美日韩国产ay| 免费国产成人午夜福利电影| 亚洲欧美日韩中文二区| 国产午夜免费高清久久影院| 国产99久久久国产无需播放器| 国产男女猛烈视频在线观看 | 精产国品一二三产区蘑菇视频| 婷婷成人丁香五月综合激情| 色猫咪av在线观看| 黑人巨茎大战欧美白妇免费|