在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-CCNC (S275) Antibody

Phospho-CCNC (S275) Antibody

  • 中文名稱：
    磷酸化-CCNC (S275)兔多克隆抗體
  • 貨號：
    CSB-PA070178
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CCNC
  • 別名：
    ccnc antibody; CCNC_HUMAN antibody; CycC antibody; Cyclin C antibody; Cyclin-C antibody; hSRB11 antibody; OTTHUMP00000016897 antibody; SRB11 homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Cyclin C around the phosphorylation site of S275.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • 基因功能參考文獻：
    1. our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression. PMID: 26042770
    2. results suggest that CCNC temporarily protects SRC-2 against degradation and this event is involved in the transcriptional regulation of SRC-2 cell cycle target genes. PMID: 25986860
    3. Cancer-mediated CDK8 point mutations (D173A and D189N) change the binding pattern of cdk8 to its partner, CycC. PMID: 24754906
    4. cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation PMID: 25344755
    5. analysis of the structure-kinetic relationship of the cyclin-dependent kinase 8 (CDK8)/cyclin C (CycC) complex PMID: 23630251
    6. 2.2-A crystal structure of CDK8/CycC in complex with sorafenib; CDK8 structure reveals a unique CycC recognition helix that explains the specificity of the CDK8/CycC pair and discrimination among the highly promiscuous binding in the CDK/cyclin family PMID: 21806996
    7. Studies establish cyclin C as a critical regulator of the G(0)/G(1) transition of human HSPCs and suggest that modulating cyclin C levels may be useful for HSC expansion and more efficient engraftment. PMID: 19967789
    8. The present observations suggest different cellular functions of cyclin C in neurons and astrocytes in alzheimer's disease. PMID: 12600719
    9. A cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently. PMID: 15084261
    10. Identification of multiple 1alpha,25(OH)2D3 response elements in the cyclin C promoter. PMID: 15863722
    11. Physical chromosome mapping of the deleted region of chromosome 6 suggests that CCNC is a candidate tumor suppressor gene. PMID: 17089020
    12. C2 isoform may play a presently unexplored and important role in mammalian testis and probably this isoform is the one that is mainly implicated in cell cycle regulation. PMID: 17385550
    13. Data suggests that the primary regulation of Cyclin C by all-trans RA and Forskolin mediates some of the cell cycle control actions of these compounds. PMID: 19683536

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Cyclin family, Cyclin C subfamily
  • 組織特異性：
    Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • 數據庫鏈接：

    HGNC: 1581

    OMIM: 123838

    KEGG: hsa:892

    STRING: 9606.ENSP00000428982

    UniGene: Hs.430646



主站蜘蛛池模板： 国产艳妇av在线出轨| 久久精品国产99国产精品| 99久久国产露脸国语对白| 久久99国产综合精品免费| 风韵人妻丰满熟妇老熟女| 337p日本大胆欧美裸体艺术| 激情av无码后入| 中文字幕亚洲欧美在线不卡 | 国产免费无遮挡吸乳视频 | 久久精品国产久精国产一老狼| 无码av动漫精品一区二区免费| 欧美日韩视频在线第一区| 永久免费看啪啪网址入口| 国产熟女一区二区三区五月婷| 在线无码中文字幕一区| 国产av中文av无码av狼人| 国产真实露脸乱子伦 | 无码少妇一区二区三区视频| 国内自拍视频一区二区三区| 中文字幕一区二区三区日韩精品| 丁香五月亚洲综合深深爱| 男女下面一进一出好爽视频 | 亚洲精品色午夜无码专区日韩| 欧美丰满大乳大屁股流白浆| 久久综合久久88中字幕文| 99久久九九社区精品| 久久国产色av免费观看| 色欲色香天天天综合网www| 婷婷久久综合九色综合| 亚洲欧美国产双大乳头| 国产乱码一区二区三区爽爽爽 | 狠狠色丁香婷婷综合尤物| 日本无卡码高清免费v| 亚洲国产精品va在线看黑人 | 成年女人毛片免费观看97| 久久国产精品免费一区二区三区 | 99这里有精品视频视频| 99国产精品久久久久久久成人热| 亚洲午夜福利av一区二区无码| 宅男66lu国产在线观看| 把腿张开老子臊烂你多p视频|