在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-ARHGAP35 (Y1087) Antibody

  • 中文名稱:
    磷酸化-ARHGAP35 (Y1087)兔多克隆抗體
  • 貨號:
    CSB-PA009000
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293T cells using Phospho-GRF-1 (Y1087) Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ARHGAP35 antibody; GAP associated protein p190 antibody; Glucocorticoid receptor DNA binding factor 1 antibody; Glucocorticoid receptor DNA-binding factor 1 antibody; Glucocorticoid receptor repression factor 1 antibody; GRF 1 antibody; GRF-1 antibody; GRF1 antibody; GRLF 1 antibody; GRLF1 antibody; GRLF1_HUMAN antibody; KIAA1722 antibody; MGC10745 antibody; p190 A antibody; p190-A antibody; P190A antibody; P190A; rat; homolog of antibody; p190ARhoGAP antibody; p190RhoGAP antibody; Rho GAP p190A antibody; Rho GTPase-activating protein 35 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human GRF-1 around the phosphorylation site of Y1087.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA. Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis. Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation. Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation. During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth. Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences.
  • 基因功能參考文獻:
    1. High ARHGAP35 expression is associated with lung adenocarcinoma. PMID: 30015929
    2. report association of APOE and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 with progressive non-fluent aphasia. PMID: 28387812
    3. interaction involves the first FF motif of p190A and the winged helix/PCI domain of eIF3A, is enhanced by serum stimulation and reduced by phosphatase treatment PMID: 28007963
    4. these data demonstrate that a complex of p190RhoGAP-A and anillin modulates RhoA-GTP levels in the cytokinetic furrow to ensure progression of cytokinesis. PMID: 25359885
    5. These results place Blk upstream of the p190RhoGAP-RhoA pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12-triggered invasion. PMID: 25025568
    6. ARHGAP35 rs1052667 polymorphism was an independent prognostic factor influencing the survival of osteosarcoma. PMID: 25136583
    7. GRF-1 expression may modify osteosarcoma prognosis and may be a potential tumor therapeutic target. PMID: 25185653
    8. A ubiquitous binding partner of p190RhoGAP, p120RasGAP (RasGAP), is expressed in much lower levels in DKO4 cells compared to DLD1, and this expression is regulated by KRAS. PMID: 24465899
    9. Overexpression of p190 mRNA associated with lung adenocarcinoma. PMID: 24043274
    10. These data suggest that the interaction of human papillomavirus E7 with p190 dysregulates this GTPase activating protein and alters the actin cytoskeleton. PMID: 24403595
    11. RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis. PMID: 23552690
    12. These results suggest that folic acid might inhibit endothelial cell migration through inhibiting the RhoA activity mediated by activating the FR/cSrc/p190RhoGAP-signaling pathway. PMID: 23178654
    13. role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation PMID: 22357615
    14. A neutrophil- and ss2 integrin-dependent transgenic model of the effector phase of autoimmune arthritis proceeds normally in p190RhoGAP-deficient bone marrow. PMID: 20675588
    15. in addition to activation of RhoGEF(s), reduction of RhoGAP (p190) is a critical mechanism by which increased RhoGTP levels are achieved in late mitosis, thereby ensuring proper cell division. PMID: 20534586
    16. Cdh1 formed a physical complex with p190 and stimulated the efficient ubiquitination of p190, both in in vitro and in vivo. PMID: 20530197
    17. p190 transiently associates with plexins, and its RhoGAP activity is increased in response to semaphorin stimulation. We conclude that p190-RhoGAP is crucially involved in semaphorin signalling to the actin cytoskeleton, via interaction with plexins. PMID: 16188938
    18. FAK-induced down-modulation of RhoA activity via p190RhoGAP is a crucial step in signaling endothelial barrier restoration after increased endothelial permeability PMID: 16308318
    19. By linking Rac1 activation and RhoA inhibition, p190 RhoGAP is critical to the protective effects of Ang-1 against endotoxin. PMID: 17562701
    20. activation of the RhoA GTPase was defective in VHL(-) cells, and this was possibly mediated by an increased activation of its inhibitor, p190RhoGAP. PMID: 18567581
    21. results suggest that co-regulation of Rho activity by p190RhoGAP and ECT2 in the cleavage furrow determines whether cells properly complete cytokinesis PMID: 18642445
    22. A previously unknown function of Brk in regulating both RhoA and Ras by phosphorylating p190 and a crucial role of this Brk-elicited signaling pathway in promoting breast malignancy. PMID: 18829532
    23. G(alpha)(13)-dependent downstream effects on RhoA activation and invasion tightly depend on cell type-specific GAP activities and that G(alpha)(13)-p190RhoGAP signaling might represent a potential target for intervention in melanoma metastasis. PMID: 18922893
    24. p190RhoGAP and p120ctn associated predominantly on the plasma membrane of cells overexpressing E-cadherin, and that E-cadherin-bound p120ctn contributed to RhoA inactivation by favoring p190RhoGAP-RhoA association. PMID: 19293150
    25. nmr temperature studies link the ability of p190RhoGAP protein domain FF1 to be phosphorylated with conformational changes in three-dimensional structure. PMID: 19393245
    26. Data show that fibroblast, endothelial and carcinoma polarity during cell migration requires FAK and is associated with a complex between FAK, p120RasGAP and p190RhoGAP (p190A), leading to p190A tyrosine phosphorylation. PMID: 19435801

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus. Cell membrane.
  • 組織特異性:
    Detected in neutrophils (at protein level).
  • 數據庫鏈接:

    HGNC: 4591

    OMIM: 605277

    KEGG: hsa:2909

    STRING: 9606.ENSP00000385720

    UniGene: Hs.509447



主站蜘蛛池模板: 亚洲欧美日韩成人综合网| 精品国产三级a在线观看网站 | 在线天堂资源www在线污| 亚洲乱码中文字幕小综合| 日本少妇寂寞少妇aaa| 天天爽夜夜爽人人爽曰| 狠狠色狠狠色综合日日不卡| 国产一区二区在线影院| 亚洲精品成人网站在线播放| 久久99er精品国产首页| 欧美日韩不卡合集视频| 午夜精品久久久久久久无码| 亚无码乱人伦一区二区| 国产 | 欧洲野花视频欧洲1| 欧美精品18videos性欧美| 欧洲无码一区二区三区在线观看| 欧美国产精品日韩在线| 精品久久久久久无码人妻蜜桃| 涩里番网污站| 天天做日日做天天添天天欢公交车 | 综合久久—本道中文字幕| 亚洲精品久久久久一区二区三区| 麻豆一区二区在我观看| 18禁裸乳无遮挡啪啪无码免费 | 337p日本欧洲亚洲大胆艺术图| 久久精品无码av| 久久久久成人精品免费播放动漫| 波多野结衣中文字幕久久| 久久精品人人槡人妻人人玩av| 国产福利一区二区三区在线视频| 精品国产一区二区三区四区阿崩| 久久99精品久久久久久齐齐 | 色欲来吧来吧天天综合网| 亚洲国产欧美在线人成最新| 国产999精品久久久久久| 人人爽人人模人人人爽人人爱| 国内精品无码一区二区三区 | 国产欧美一区二区精品性色| 人妻精品国产一区二区| 久久成人国产精品无码| 欧美群妇大交群|