在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARHGAP35 Antibody

ARHGAP35 Antibody

  • 中文名稱：
    ARHGAP35兔多克隆抗體
  • 貨號(hào)：
    CSB-PA009006
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ARHGAP35 antibody; GAP associated protein p190 antibody; Glucocorticoid receptor DNA binding factor 1 antibody; Glucocorticoid receptor DNA-binding factor 1 antibody; Glucocorticoid receptor repression factor 1 antibody; GRF 1 antibody; GRF-1 antibody; GRF1 antibody; GRLF 1 antibody; GRLF1 antibody; GRLF1_HUMAN antibody; KIAA1722 antibody; MGC10745 antibody; p190 A antibody; p190-A antibody; P190A antibody; P190A; rat; homolog of antibody; p190ARhoGAP antibody; p190RhoGAP antibody; Rho GAP p190A antibody; Rho GTPase-activating protein 35 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human GRF-1 around the non-phosphorylation site of Y1105.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA. Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis. Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation. Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation. During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth. Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences.
  • 基因功能參考文獻(xiàn)：
    1. High ARHGAP35 expression is associated with lung adenocarcinoma. PMID: 30015929
    2. report association of APOE and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 with progressive non-fluent aphasia. PMID: 28387812
    3. interaction involves the first FF motif of p190A and the winged helix/PCI domain of eIF3A, is enhanced by serum stimulation and reduced by phosphatase treatment PMID: 28007963
    4. these data demonstrate that a complex of p190RhoGAP-A and anillin modulates RhoA-GTP levels in the cytokinetic furrow to ensure progression of cytokinesis. PMID: 25359885
    5. These results place Blk upstream of the p190RhoGAP-RhoA pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12-triggered invasion. PMID: 25025568
    6. ARHGAP35 rs1052667 polymorphism was an independent prognostic factor influencing the survival of osteosarcoma. PMID: 25136583
    7. GRF-1 expression may modify osteosarcoma prognosis and may be a potential tumor therapeutic target. PMID: 25185653
    8. A ubiquitous binding partner of p190RhoGAP, p120RasGAP (RasGAP), is expressed in much lower levels in DKO4 cells compared to DLD1, and this expression is regulated by KRAS. PMID: 24465899
    9. Overexpression of p190 mRNA associated with lung adenocarcinoma. PMID: 24043274
    10. These data suggest that the interaction of human papillomavirus E7 with p190 dysregulates this GTPase activating protein and alters the actin cytoskeleton. PMID: 24403595
    11. RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis. PMID: 23552690
    12. These results suggest that folic acid might inhibit endothelial cell migration through inhibiting the RhoA activity mediated by activating the FR/cSrc/p190RhoGAP-signaling pathway. PMID: 23178654
    13. role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation PMID: 22357615
    14. A neutrophil- and ss2 integrin-dependent transgenic model of the effector phase of autoimmune arthritis proceeds normally in p190RhoGAP-deficient bone marrow. PMID: 20675588
    15. in addition to activation of RhoGEF(s), reduction of RhoGAP (p190) is a critical mechanism by which increased RhoGTP levels are achieved in late mitosis, thereby ensuring proper cell division. PMID: 20534586
    16. Cdh1 formed a physical complex with p190 and stimulated the efficient ubiquitination of p190, both in in vitro and in vivo. PMID: 20530197
    17. p190 transiently associates with plexins, and its RhoGAP activity is increased in response to semaphorin stimulation. We conclude that p190-RhoGAP is crucially involved in semaphorin signalling to the actin cytoskeleton, via interaction with plexins. PMID: 16188938
    18. FAK-induced down-modulation of RhoA activity via p190RhoGAP is a crucial step in signaling endothelial barrier restoration after increased endothelial permeability PMID: 16308318
    19. By linking Rac1 activation and RhoA inhibition, p190 RhoGAP is critical to the protective effects of Ang-1 against endotoxin. PMID: 17562701
    20. activation of the RhoA GTPase was defective in VHL(-) cells, and this was possibly mediated by an increased activation of its inhibitor, p190RhoGAP. PMID: 18567581
    21. results suggest that co-regulation of Rho activity by p190RhoGAP and ECT2 in the cleavage furrow determines whether cells properly complete cytokinesis PMID: 18642445
    22. A previously unknown function of Brk in regulating both RhoA and Ras by phosphorylating p190 and a crucial role of this Brk-elicited signaling pathway in promoting breast malignancy. PMID: 18829532
    23. G(alpha)(13)-dependent downstream effects on RhoA activation and invasion tightly depend on cell type-specific GAP activities and that G(alpha)(13)-p190RhoGAP signaling might represent a potential target for intervention in melanoma metastasis. PMID: 18922893
    24. p190RhoGAP and p120ctn associated predominantly on the plasma membrane of cells overexpressing E-cadherin, and that E-cadherin-bound p120ctn contributed to RhoA inactivation by favoring p190RhoGAP-RhoA association. PMID: 19293150
    25. nmr temperature studies link the ability of p190RhoGAP protein domain FF1 to be phosphorylated with conformational changes in three-dimensional structure. PMID: 19393245
    26. Data show that fibroblast, endothelial and carcinoma polarity during cell migration requires FAK and is associated with a complex between FAK, p120RasGAP and p190RhoGAP (p190A), leading to p190A tyrosine phosphorylation. PMID: 19435801

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus. Cell membrane.
  • 組織特異性：
    Detected in neutrophils (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4591

    OMIM: 605277

    KEGG: hsa:2909

    STRING: 9606.ENSP00000385720

    UniGene: Hs.509447



主站蜘蛛池模板： 久久精品国产免费观看| 中文字幕乱码一区av久久不卡| 中文字幕乱码一区av久久不卡| 国产精品亚洲二区在线播放| 国产精品视频一区二区亚瑟| 日本成熟少妇喷浆视频| 亚洲日韩亚洲另类| 美女大量吞精在线观看456| 久久亚洲a片com人成| 成人国产mv免费视频| 人妻护士在线波多野结衣| 国产成人无码a区在线观看视频app| 337p日本欧洲亚洲大胆在线| 熟妇人妻一区二区三区四区 | 天堂а√中文最新版在线| 国产好吊看视频在线观看| 亚洲乱码中文字幕手机在线| 亚洲成在人线在线播放无码| 欧美色综合天天久久综合精品| √8天堂资源地址中文在线| 亚洲综合区小说区激情区| 久久精品亚洲综合专区| 亚洲区小说区图片区qvod| 久久精品国产99久久久古代| 高清粉嫩无套内谢国语播放 | 国产在线观看无码不卡| 无码人妻黑人中文字幕| 伦埋琪琪电影院久久| 无码日本精品xxxxxxxxx| 国产主播一区二区三区在线观看| 日日噜噜夜夜狠狠va视频| 亚洲精品一线二线三线无人区| 国产亚洲欧美日韩夜色凹凸成人| 日日橹狠狠爱欧美视频| 久久精品aⅴ无码中文字字幕| 精品国偷自产在线| 国产偷抇久久精品a片69| 狠狠躁夜夜躁无码中文字幕| 欧美乱强伦xxxx孕妇| 日本va欧美va精品发布| 国产美女无遮挡裸色视频|