在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-ACAP1 (S554) Antibody

  • 中文名稱:
    磷酸化-ACAP1 (S554)兔多克隆抗體
  • 貨號(hào):
    CSB-PA080059
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ACAP 1 antibody; ACAP1 antibody; ACAP1_HUMAN antibody; Arf GAP with coiled coil ANK repeat and PH domains 1 antibody; Arf GAP with coiled coil; ankyrin repeat; and pleckstrin homology domains 1 antibody; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with coiled-coil; ankyrin repeat and PH domains 1 antibody; CENT B1 antibody; Centaurin beta 1 antibody; Centaurin-beta-1 antibody; CENTB 1 antibody; Cnt b1 antibody; Cnt-b1 antibody; Cntb1 antibody; KIAA0050 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from Human ACAP1 around the phosphorylation site of S554.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
  • 基因功能參考文獻(xiàn):
    1. The serum lever of Alzheimer's disease were decrease and the expression of ACAP1 strongly correlated with the Mini-Mental State Examination scores of the AD patients PMID: 25502766
    2. ACAP1 and ARAP2 each colocalize with Arf6 but they did not colocalize with each other and have opposing effects on focal adhesions. PMID: 25225293
    3. CENTB1 was up-regulated in patients with active UC as compared to UC remission and healthy control groups suggesting that it is involved in the inflammatory process. PMID: 23317930
    4. phosphorylation of ACAP1 relieves a localized mechanism of autoinhibition in regulating cargo binding PMID: 22645133
    5. the oncogenic potential of USP6 is linked to its ability to integrate cell migration and cytokinesis by regulating Arf6/ACAP1. PMID: 22188517
    6. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. PMID: 15525538
    7. CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses PMID: 17005562
    8. Results suggest that two ARF6 downstream molecules, PIP5K and ACAP1, function together in endosomal tubulation and that phosphoinositide levels may regulate endosomal dynamics. PMID: 17010122
    9. Results suggest that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings. PMID: 17664335
    10. ACAP1 has robust, constitutive Arf6 GAP activity in vivo, with little activity toward Arf1. PMID: 18003747
    11. Centaurin beta1/KIAA0050, is a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. Binding of phosphoinositides to a pleckstrin homology domain may regulate subcellular localisation and activity. PMID: 11050434
    12. Centaurin beta1/KIAA0050, or ACAP1, is a phospholipid dependent, ARF6 preferring GTPase-activating protein. It can regulate cytoskeletal and membrane trafficking events in the cell periphery and may be regulated via a phosphoinositide-binding PH domain. PMID: 11062263

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 組織特異性:
    Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16467

    OMIM: 607763

    KEGG: hsa:9744

    STRING: 9606.ENSP00000158762

    UniGene: Hs.337242



主站蜘蛛池模板: 国产百合互慰吃奶互揉视频| 亚洲综合av色婷婷| 久久性色欲av免费精品观看| 亚洲成色综合网站在线| 人人玩人人添人人澡欧美| 欧美成年网站色a| 国产午夜福利片在线观看| 99视频在线精品免费观看6| 国产超碰无码最新上传| 少妇大叫太大太爽受不了在线观看| 国产女人乱子对白av片| 一 级 黄 色 片免费网站| 亚洲国产精品久久久久久| 人妻系列无码专区喂奶| 99久re热视频这里只有精品6| 日韩精品久久久久久免费| 国产乱人激情h在线观看| 精品噜噜噜噜久久久久久久久| 国产成人精品视觉盛宴| 欧美性猛交内射兽交老熟妇 | 久久精品国产色蜜蜜麻豆| 亚洲熟妇无码久久精品| 日本欧美亚洲中文在线观看| 亚洲精品乱码久久久久久自慰| 欧美老妇大p毛茸茸| 久久久久青草线综合超碰| 亚洲成亚洲成网| 国产成人无码av一区二区| 亚洲午夜福利在线观看| 国内精品久久久久久久久齐齐| 国内精品自线在拍2020不卡| 亚洲欧美综合区自拍另类| 亚洲日韩国产成网在线观看| 欧亚精品一区三区免费| 亚洲欧洲日产无码中文字幕| 国产亚洲产品影市在线产品| 中年熟妇的大黑p| 美乳丰满人妻无码视频| 亚洲精品一卡2卡三卡4卡| 亚洲 小说区 图片区 都市| 精品无人区一区二区三区在线|