在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ACAP1 Antibody

ACAP1 Antibody

  • 中文名稱：
    ACAP1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA001131GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ACAP 1 antibody; ACAP1 antibody; ACAP1_HUMAN antibody; Arf GAP with coiled coil ANK repeat and PH domains 1 antibody; Arf GAP with coiled coil; ankyrin repeat; and pleckstrin homology domains 1 antibody; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with coiled-coil; ankyrin repeat and PH domains 1 antibody; CENT B1 antibody; Centaurin beta 1 antibody; Centaurin-beta-1 antibody; CENTB 1 antibody; Cnt b1 antibody; Cnt-b1 antibody; Cntb1 antibody; KIAA0050 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ACAP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
  • 基因功能參考文獻(xiàn)：
    1. The serum lever of Alzheimer's disease were decrease and the expression of ACAP1 strongly correlated with the Mini-Mental State Examination scores of the AD patients PMID: 25502766
    2. ACAP1 and ARAP2 each colocalize with Arf6 but they did not colocalize with each other and have opposing effects on focal adhesions. PMID: 25225293
    3. CENTB1 was up-regulated in patients with active UC as compared to UC remission and healthy control groups suggesting that it is involved in the inflammatory process. PMID: 23317930
    4. phosphorylation of ACAP1 relieves a localized mechanism of autoinhibition in regulating cargo binding PMID: 22645133
    5. the oncogenic potential of USP6 is linked to its ability to integrate cell migration and cytokinesis by regulating Arf6/ACAP1. PMID: 22188517
    6. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. PMID: 15525538
    7. CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses PMID: 17005562
    8. Results suggest that two ARF6 downstream molecules, PIP5K and ACAP1, function together in endosomal tubulation and that phosphoinositide levels may regulate endosomal dynamics. PMID: 17010122
    9. Results suggest that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings. PMID: 17664335
    10. ACAP1 has robust, constitutive Arf6 GAP activity in vivo, with little activity toward Arf1. PMID: 18003747
    11. Centaurin beta1/KIAA0050, is a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. Binding of phosphoinositides to a pleckstrin homology domain may regulate subcellular localisation and activity. PMID: 11050434
    12. Centaurin beta1/KIAA0050, or ACAP1, is a phospholipid dependent, ARF6 preferring GTPase-activating protein. It can regulate cytoskeletal and membrane trafficking events in the cell periphery and may be regulated via a phosphoinositide-binding PH domain. PMID: 11062263

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 組織特異性：
    Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16467

    OMIM: 607763

    KEGG: hsa:9744

    STRING: 9606.ENSP00000158762

    UniGene: Hs.337242



主站蜘蛛池模板： 国产成人无码av在线播放不卡| 五十路丰满中年熟女中出| 亚洲精品图片区小说区| 99久久99久久精品免费观看| 亚洲a∨无码无在线观看| 免费特级毛片| 国产高潮流白浆免费观看| 精品国产福利久久久| 天天天狠天天碰天天爱| 久久久噜噜噜久久| 边添小泬边狠狠躁视频| 永久免费看啪啪的网站| 日产精品1区2区3区| 在线a久青草视频在线观看| 小荡货好紧好爽奶头大视频 | 人妻无码中文专区久久五月婷| 人妻去按摩店被黑人按中出 | 蜜桃臀无码内射一区二区三区| 暖暖 在线 日本 免费 中文| 国产激情大臿免费视频| 免费人成又黄又爽的视频 | 亚洲h成年动漫在线观看网站| 亚洲老熟女av一区二区在线播放| 女女互磨互喷水高潮les呻吟| 国产麻豆剧果冻传媒一区| 国产精品亚洲五月天高清| 亚洲精品综合欧美一区二区三区 | 久久96国产精品久久久| 国产粉嫩嫩00在线正在播放| 国产精品无码av不卡顿| 性色av无码一区二区三区人妻| 国产精品一区二区av| 92午夜少妇极品福利无码电影| av大片在线无码免费| 亚洲人成影院在线观看| 大肉大捧一进一出好爽动态图| 蜜芽av无码精品国产午夜| 亚洲熟妇丰满大屁股熟妇| 四虎国产成人永久精品免费| 久久亚洲精品中文字幕一区 | 欧美丰满熟妇xxxxx|