在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Pdgfd Antibody

  • 中文名稱:
    Pdgfd兔多克隆抗體
  • 貨號:
    CSB-PA852889LA01MO
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescent analysis of HepG2 cells using CSB-PA852889LA01MO at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate
      All lanes: Pdgfd antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 43, 31 kDa
      Observed band size: 43 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) Pdgfd Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Pdgfd antibody; Scdgfb antibody; Platelet-derived growth factor D antibody; PDGF-D antibody; Spinal cord-derived growth factor B antibody; SCDGF-B) [Cleaved into: Platelet-derived growth factor D antibody; latent form antibody; PDGFD latent form); Platelet-derived growth factor D antibody; receptor-binding form antibody; PDGFD receptor-binding form)] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse, Human
  • 免疫原:
    Recombinant Mouse Platelet-derived growth factor D protein (24-370AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,Pdgfd Antibody (CSB-PA852889LA01MO),的標記方式是Non-conjugated。對于Pdgfd Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA852889LB01MO Pdgfd Antibody, HRP conjugated ELISA
    FITC CSB-PA852889LC01MO Pdgfd Antibody, FITC conjugated
    Biotin CSB-PA852889LD01MO Pdgfd Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
  • 基因功能參考文獻:
    1. Data (including data from studies using transgenic/mutant mice and cells from such mice) suggest that Pdgfd promotes cell proliferation, cell migration, and expression of inflammatory factors in adventitial fibroblasts; in obese mice, inhibition of Pdgfd significantly reduces aortic aneurysm formation (induced by infusion of angiotensin II). PMID: 29794241
    2. upregulated in kidney fibrosis, may mediate renal scarring, and is dispensable for normal kidney development and physiological functions PMID: 26924050
    3. Inactivation of the Pdgfd gene resulted in a mild phenotype in C57BL/6 mice, and the offspring was viable, fertile and generally in good health. PMID: 27032083
    4. PDGF-D intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2/MMP-9 system, and PDGF-D signaling is mediated through both PDGF-alpha and -beta receptors. PMID: 25576870
    5. Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex PMID: 25391964
    6. PDGF D represents a potentially promising target for prostate carcinoma treatment resistance in the absence of PTEN function, and warrants further laboratory evaluation and clinical study. PMID: 24331662
    7. Data indicate that the proteolytic processing of full-length PDGF-D is required for PDGF-D activation of preosteoclasts, and that beta-PDGFR is present in activated osteoclasts. PMID: 22158043
    8. identified PDGF-DD as an important target gene for antiangiogenic therapy due to its pleiotropic effects on vascular and non-vascular cells. PDGF-DD inhibition may offer new therapeutic options to treat neovascular diseases PMID: 20231273
    9. Failure of laminin alpha4-mediated down-regulation of PDGF activity contributes to the progressive renal lesions in this animal model. PMID: 20035058
    10. These results suggest that PDGF-D induce cellular transformation and promote tumour growth by accelerating the proliferation rate of the tumour cells, and by stimulation of tumour neovascularization. PMID: 12629513
    11. splicing variant results in significant differences in peptide expression and function PMID: 12890490
    12. PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF-Rbeta in obstructive ureteral nephropathy PMID: 14514732
    13. PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns. PMID: 19028801

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    PDGF/VEGF growth factor family
  • 組織特異性:
    Expressed at high levels in developing heart, lung, kidney and some muscle derivatives. Moderately expressed in liver, brain and testis. In the kidney, localized to glomerular mesangial cells and vascular smooth muscle cells. Up-regulated in areas of rena
  • 數據庫鏈接:


主站蜘蛛池模板: 九个美女露脸撒尿嘘嘘视频| 久在线观看福利视频| 色悠久久久久久久综合网伊人| 精品国产杨幂在线观看| 不卡av中文字幕手机看 | 国产精品久久午夜夜伦鲁鲁| 天天干天天日| 婷婷久久久亚洲欧洲日产国码av| 久久精品人人做人人爱爱漫画| 少妇被爽到高潮喷水久久欧美精品| 人妻 丝袜美腿 中文字幕| av一区二区三区人妻少妇| 玩弄丰满少妇人妻视频| 国产免费拔擦拔擦8x高清在线人| 中文字幕av在线一二三区| 日本国产网曝视频在线观看 | 蜜桃网站入口可看18禁| 久久国产高潮流白浆免费观看| 欧美丰满熟妇bbbbbb| 国产肉体xxxx裸体137大胆| 女狠狠噜天天噜日日噜| 欧美人与动牲交免费观看| 少妇高潮喷水久久久影院| 国产黄网永久免费视频大全| 又粗又硬又黄又爽的视频永久 | 婷婷亚洲综合五月天小说| 丝袜人妻一区二区三区| 亚洲综合电影小说图片区| 国产乱女乱子视频在线播放| 色婷婷av久久久久久久| 老司机久久精品最新免费| 无码人妻一区、二区、三区免费视频| 精品久久久无码中文字幕| 中文字幕人妻高清乱码| 久久www成人免费网站| 欧美国产日韩a在线视频下载| 2019nv天堂香蕉在线观看| 亚洲国产精品国自产拍电影| 精品久久久久中文字幕app| 成人aaa片一区国产精品| 首页 综合国产 亚洲 丝袜|