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  4. PVRL3 Antibody

PVRL3 Antibody

  • 中文名稱：
    PVRL3兔多克隆抗體
  • 貨號：
    CSB-PA003390
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of A549 cells using Nectin 3 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CD113 antibody; CDw113 antibody; DKFZP566B0846 antibody; FLJ90624 antibody; Nectin-3 antibody; Nectin3 antibody; Poliovirus receptor related 3 antibody; Poliovirus receptor related protein 3 antibody; Poliovirus receptor-like 3 antibody; Poliovirus receptor-related protein 3 antibody; PPR3 antibody; PRR3 antibody; Pvrl3 antibody; PVRL3_HUMAN antibody; PVRR3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Nectin 3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
  • 基因功能參考文獻(xiàn)：
    1. Nectin-3 mutation in men with severe teratospermia PMID: 28689229
    2. Data suggest that 3 independent regions of TcdB (Clostridium difficile toxin B; 1372-1493, 1493-1848, 1851-2366) contribute to binding and entry of TcdB into mammalian cells; residues 1372-1493 are sufficient for interaction with PVRL3. PMID: 26602083
    3. Expression of nectin-3 in pancreatic cancer can be a prognostic factor. PMID: 25690753
    4. PVRL3 is a physiologically relevant binding partner that can serve as a target for the prevention of TcdB-induced cytotoxicity in C. difficile infection. PMID: 26038560
    5. Nectin-3 is associated with the formation of cell junctions and be a putative suppressor molecule to the invasion of breast cancer cells. PMID: 24386110
    6. Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation. PMID: 24116228
    7. Data suggest that expression of nectin-3 is up-regulated in eutopic endometrium of patients with endometriosis as compared with control subjects and up-regulated in all endometriotic lesions investigated compared with eutopic endometrium. PMID: 22926846

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
  • 蛋白家族：
    Nectin family
  • 組織特異性：
    Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17664

    OMIM: 607147

    KEGG: hsa:25945

    STRING: 9606.ENSP00000418070

    UniGene: Hs.293917



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