在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTRH2 Antibody

  • 中文名稱:
    PTRH2兔多克隆抗體
  • 貨號:
    CSB-PA019072GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PTRH2
  • 別名:
    Bcl 2 inhibitor of transcription 1 antibody; Bcl-2 inhibitor of transcription 1 antibody; BIT 1 antibody; BIT1 antibody; CGI 147 antibody; CGI147 antibody; mitochondrial antibody; Peptidyl tRNA hydrolase 2 mitochondrial antibody; Peptidyl-tRNA hydrolase 2 antibody; PTH 2 antibody; PTH2 antibody; PTH2_HUMAN antibody; PTRH 2 antibody; PTRH2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PTRH2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.; Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.
  • 基因功能參考文獻:
    1. studies indicate Bit1 is an inhibitor of EMT and metastasis in lung cancer and hence can serve as a molecular target in curbing lung cancer aggressiveness PMID: 27655370
    2. These collective findings indicate that loss of Bit1 expression contributes to the acquisition of malignant phenotype of human lung epithelial cells via Erk activation-induced suppression of E-cadherin expression. PMID: 29170133
    3. This study reports on five infantile-onset multisystem neurologic, endocrine, and pancreatic disease (IMNEPD) patients with a different homozygous PTRH2 mutation, broaden the phenotypic spectrum of the disease and differentiate common symptoms and interindividual variability in IMNEPD associated with a unique mutation. PMID: 27129381
    4. Homozygous mutation in PTRH2 gene causes progressive sensorineural deafness and peripheral neuropathy in three sisters from a consanguineous family. PMID: 28328138
    5. Bcl-2 expression patterns in various differentiated esophageal squamous cell carcinoma were higher than those in corresponding normal esophageal tissues with no statistical differences ( p > 0.05). Importantly, Bit1 expression was positively correlated with both matrix metalloproteinase 2 and Bcl-2 expression in esophageal squamous cell carcinoma and esophageal adenocarcinoma tissues ( p < 0.05). PMID: 28488526
    6. Our data establishes a PTRH2 mutation as a novel driver of congenital muscle degeneration and identifies a potential novel target to treat muscle myopathies. PMID: 28175314
    7. Bit1 may be an important regulator in cell growth, apoptosis, migration and invasion of esophageal squamous cell carcinoma via targeting FAK-paxillin pathway. PMID: 26956728
    8. these findings suggest a tumor suppressive role of the caspase-independent anoikis effector Bit1 in lung cancer. PMID: 25003198
    9. Reduction of the Bit1 level in cytosol, regulated by E2 binding to ESR1, was mainly mediated through PI3K/AKT pathways. PMID: 25211327
    10. Bit1 plays pivotal roles in the development and progression of ESCC, and its biological functions in ESCC may be closely associated with AIF and Bcl-2 levels. PMID: 23955799
    11. TLE1 inhibits the Bit1 anoikis pathway by reducing the formation of the proapoptotic Bit1-AES complex in part through sequestration of AES in the nucleus. PMID: 22952044
    12. Bit1 may be a useful pathological marker and a prognostic marker for serous papillary adenocarcinomas outcome. PMID: 23259782
    13. Data indicate that the cell death domain (CDD) to the N-terminal 62 amino acids of Bit1 was more potent in killing cells than the full-length Bit1 protein when equivalent amounts of cDNA were transfected. PMID: 23248118
    14. downregulation of Bit1 conferred cancer cells with enhanced anoikis resistance, adhesive and migratory properties in vitro PMID: 21886829
    15. Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway PMID: 21383007
    16. Results identify Bit1, a mitochondrial protein released into the cytoplasm during apoptosis that forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein PMID: 15006356
    17. Reduced expression of the proapoptotic proteins Bit1 or overexpression of Bcl-2 improved myoblast transplantation survival. PMID: 17511679
    18. the PKD serine/threonine kinase is one of the signaling molecules through which integrin-mediated cell attachment controls Bit1 activity and anoikis PMID: 18703509
    19. TAp63gamma could induce apoptosis in human esophageal squamous cancer EC9706 cells, through at least releasing AIF and Bit1 from mitochindria into cytosol and nucleus, where apoptotic cascade takes place. PMID: 19578750

    顯示更多

    收起更多

  • 相關疾病:
    Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset (IMNEPD)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    PTH2 family
  • 數據庫鏈接:

    HGNC: 24265

    OMIM: 608625

    KEGG: hsa:51651

    STRING: 9606.ENSP00000376758

    UniGene: Hs.12677



主站蜘蛛池模板: 婷婷久久综合九色综合绿巨人| 国产69精品久久久久人妻| 久久精品国产导航| 欧美成人免费全部| 国产精品高潮露脸在线观看| 久久精品人人做人人综合| 久久久久久成人毛片免费看| 色欲欲www成人网站| 2020最新无码国产在线观看| 日本 精品 高清不卡| 中文字幕爆乳julia女教师| 精品三级av无码一区| 久久精品囯产精品亚洲| 久久精品国产亚洲αv忘忧草| 天天做天天爱夜夜夜爽毛片| а√天堂8资源中文在线| 国产麻豆精品福利在线| 亚洲欧洲日韩综合久久| 国产a在亚洲线播放| 乱码午夜-极国产极内射| 色六月婷婷亚洲婷婷六月| 中文字幕在线日亚洲9| 婷婷亚洲久悠悠色悠在线播放| 亚洲香蕉aⅴ视频在线播放| 图片区小说区亚洲欧美自拍| 欧美老妇与禽交| 色播亚洲视频在线观看| 被c到高潮疯狂喷水国产| 热久久视久久精品18| 国产sm调教折磨视频| 内射巨臀欧美在线视频| 小草国产精品情侣| 女人扒开屁股桶爽30分钟| 都市激情 在线 亚洲 国产| 啪啪激情婷婷久久婷婷色五月 | 伊人色合天天久久综合网| 国产一区二区精品丝袜| 久久精品国产亚洲夜色av网站| 男女做爰无遮挡性视频| 曰韩内射六十七十老熟女影视 | 国产精品久久久天天影视香蕉|