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PTRH2 Antibody

  • 中文名稱:
    PTRH2兔多克隆抗體
  • 貨號:
    CSB-PA837133ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Peptidyl-tRNA hydrolase 2, mitochondrial antibody at 4μg/ml
      Lane 1: MM231 whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 19 kDa
      Observed band size: 19 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA837133ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PTRH2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PTRH2
  • 別名:
    Bcl 2 inhibitor of transcription 1 antibody; Bcl-2 inhibitor of transcription 1 antibody; BIT 1 antibody; BIT1 antibody; CGI 147 antibody; CGI147 antibody; mitochondrial antibody; Peptidyl tRNA hydrolase 2 mitochondrial antibody; Peptidyl-tRNA hydrolase 2 antibody; PTH 2 antibody; PTH2 antibody; PTH2_HUMAN antibody; PTRH 2 antibody; PTRH2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Peptidyl-tRNA hydrolase 2, mitochondrial protein (40-179AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.; Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.
  • 基因功能參考文獻:
    1. studies indicate Bit1 is an inhibitor of EMT and metastasis in lung cancer and hence can serve as a molecular target in curbing lung cancer aggressiveness PMID: 27655370
    2. These collective findings indicate that loss of Bit1 expression contributes to the acquisition of malignant phenotype of human lung epithelial cells via Erk activation-induced suppression of E-cadherin expression. PMID: 29170133
    3. This study reports on five infantile-onset multisystem neurologic, endocrine, and pancreatic disease (IMNEPD) patients with a different homozygous PTRH2 mutation, broaden the phenotypic spectrum of the disease and differentiate common symptoms and interindividual variability in IMNEPD associated with a unique mutation. PMID: 27129381
    4. Homozygous mutation in PTRH2 gene causes progressive sensorineural deafness and peripheral neuropathy in three sisters from a consanguineous family. PMID: 28328138
    5. Bcl-2 expression patterns in various differentiated esophageal squamous cell carcinoma were higher than those in corresponding normal esophageal tissues with no statistical differences ( p > 0.05). Importantly, Bit1 expression was positively correlated with both matrix metalloproteinase 2 and Bcl-2 expression in esophageal squamous cell carcinoma and esophageal adenocarcinoma tissues ( p < 0.05). PMID: 28488526
    6. Our data establishes a PTRH2 mutation as a novel driver of congenital muscle degeneration and identifies a potential novel target to treat muscle myopathies. PMID: 28175314
    7. Bit1 may be an important regulator in cell growth, apoptosis, migration and invasion of esophageal squamous cell carcinoma via targeting FAK-paxillin pathway. PMID: 26956728
    8. these findings suggest a tumor suppressive role of the caspase-independent anoikis effector Bit1 in lung cancer. PMID: 25003198
    9. Reduction of the Bit1 level in cytosol, regulated by E2 binding to ESR1, was mainly mediated through PI3K/AKT pathways. PMID: 25211327
    10. Bit1 plays pivotal roles in the development and progression of ESCC, and its biological functions in ESCC may be closely associated with AIF and Bcl-2 levels. PMID: 23955799
    11. TLE1 inhibits the Bit1 anoikis pathway by reducing the formation of the proapoptotic Bit1-AES complex in part through sequestration of AES in the nucleus. PMID: 22952044
    12. Bit1 may be a useful pathological marker and a prognostic marker for serous papillary adenocarcinomas outcome. PMID: 23259782
    13. Data indicate that the cell death domain (CDD) to the N-terminal 62 amino acids of Bit1 was more potent in killing cells than the full-length Bit1 protein when equivalent amounts of cDNA were transfected. PMID: 23248118
    14. downregulation of Bit1 conferred cancer cells with enhanced anoikis resistance, adhesive and migratory properties in vitro PMID: 21886829
    15. Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway PMID: 21383007
    16. Results identify Bit1, a mitochondrial protein released into the cytoplasm during apoptosis that forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein PMID: 15006356
    17. Reduced expression of the proapoptotic proteins Bit1 or overexpression of Bcl-2 improved myoblast transplantation survival. PMID: 17511679
    18. the PKD serine/threonine kinase is one of the signaling molecules through which integrin-mediated cell attachment controls Bit1 activity and anoikis PMID: 18703509
    19. TAp63gamma could induce apoptosis in human esophageal squamous cancer EC9706 cells, through at least releasing AIF and Bit1 from mitochindria into cytosol and nucleus, where apoptotic cascade takes place. PMID: 19578750

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  • 相關疾病:
    Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset (IMNEPD)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    PTH2 family
  • 數據庫鏈接:

    HGNC: 24265

    OMIM: 608625

    KEGG: hsa:51651

    STRING: 9606.ENSP00000376758

    UniGene: Hs.12677



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