在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PTPRN Antibody, Biotin conjugated

PTPRN Antibody, Biotin conjugated

  • 中文名稱：
    PTPRN兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA613703LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PTPRN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CA 512 antibody; FLJ16131 antibody; IA 2 antibody; IA 2/PTP antibody; IA2 antibody; IA2/PTP antibody; ICA 3 antibody; ICA 512 antibody; ICA3 antibody; ICA512 antibody; Islet cell antigen 2 antibody; Islet cell antigen 512 antibody; Islet cell autoantigen 3 antibody; Protein tyrosine phosphatase like N antibody; Protein tyrosine phosphatase like N precursor antibody; Protein tyrosine phosphatase receptor type N antibody; PTP IA 2 antibody; PTP IA-2 antibody; PTP IA2 antibody; PTPIA 2 antibody; PTPN antibody; Ptprn antibody; PTPRN protein antibody; PTPRN_HUMAN antibody; R PTP N antibody; R-PTP-N antibody; Receptor type tyrosine protein phosphatase like N antibody; Receptor-type tyrosine-protein phosphatase-like N antibody; RPTPN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Receptor-type tyrosine-protein phosphatase-like N protein (35-575AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization.; ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2.; ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4. Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3. ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis.
  • 基因功能參考文獻：
    1. E. coli GI724 strain emerged as a handy source of recombinant IA-2ic, achieving high levels of expression as a thioredoxin fusion protein, adequately validated and applicable to the development of innovative and cost-effective immunoassays for IA-2A detection in most laboratories. PMID: 27881117
    2. Identification of amino acids contributing to distinct epitopes on IA-2, with both HLA-DR and HLA-DQ alleles influencing epitope specificity. PMID: 26564179
    3. RESP18HD is required for efficient sorting of ICA512 to secretory granules: RESP18HD is a key determinant for ICA512 granule targeting. PMID: 26836020
    4. The binding of CREB to the promoter region, -216 to +115, enhanced IA-2 transcription by more than fivefold. PMID: 25528004
    5. Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 antibodies versus those patients with negative auto-antibodies and GAD65+ auto-antibodies after simultaneous pancreas kidney transplantation. PMID: 25645784
    6. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes. PMID: 23396399
    7. identification of cysteines that are critical for IA-2A binding of autoantibodies in patients with newly diagnosed type 1 diabetes PMID: 22966073
    8. the IA-2A autoantibody response in children is intense with rapid maturation against immunogenic epitopes and a strong association with diabetes development PMID: 23110943
    9. Letter: report lack of anti-IA2 autoantibodies in primary antiphospholipid syndrome. PMID: 21442164
    10. analysis of protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain PMID: 21935384
    11. ZnT8A, GADA and IA-2A are autoantibodies that may have a role in successful pancreas graft survival PMID: 21792090
    12. In families with type 1 diabetes, there was a female predominance and more family history of associated autoimmune diseases (AAIDs) in the group with AAIDs, and less frequent anti-IA-2 antibodies PMID: 21744463
    13. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
    14. Studies indicate that T1DM can be detected by determining four autoantibodies, namely those antibodies against insulin, glutamic acid decarboxylase 65, insulinoma antigen (IA)-2 (ICA512) and the zinc transporter ZnT8. PMID: 21073664
    15. Risk of autoantibody seroconversion among children followed in DPT-1 is age dependent PMID: 21270193
    16. Data show that significantly increased expression of MCP-1, IL-2 and PTPR-N was observed in Tourette's syndrome cases. PMID: 20193755
    17. T cells stimulated in vitro by the IA-2 epitope express IFN-gamma when restimulated by the similar rotavirus VP7 peptide. PMID: 20083660
    18. Report a chimeric assay providing an efficient and economical technique to screen for islet autoantibodies reacting with IA-2 and ZnT8 in type 1 diabetes mellitus. PMID: 20035758
    19. ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies. PMID: 11908951
    20. Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay. PMID: 12021115
    21. BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India. PMID: 12021127
    22. findings indicate that glutamine at position 862, and residues 876-880 of the WPD loop of IA-2 are important for several of the IA-2 specific PTP domain epitopes PMID: 14624760
    23. The islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated with the insulin secretory granules (SGs) of pancreatic beta-cells. PMID: 15596545
    24. Measuring IA-2A is useful for the diagnosis and prognosis of type 1 diabetes in Japanese. PMID: 15620435
    25. IA-2 is an important regulator of dense core vesicle number and glucose-induced and basal insulin secretion in beta cells. PMID: 15939893
    26. identification of proteins that interact with IA-2, the IA-2 interactome; the IA-2 interactome based on pull-down experiments, currently consists of 12 proteins; identification of these interacting proteins provides clues as to how IA-2 functions PMID: 16273344
    27. Autoantibodies in type 1 diabetes for this protein provide a model for other autoimmune diseases. PMID: 18373080
    28. HLA class II alleles strongly influence the prevalence of IA-2A in type 1 diabetes. PMID: 18504544
    29. Inexpensive, nonradioactive method for the detection of autoantibodies cell-prepared PTPRN (also known as IA-2) in diabetics. PMID: 18535195
    30. The study identifies a region of IA-2 frequently recognised by antibodies in Type 1 diabetes and demonstrates that these responses are associated with T-cells secreting IL-10 in response to a neighbouring determinant. PMID: 19447008

    顯示更多

    收起更多

  • 相關疾病：
    Autoantigen in insulin-dependent diabetes mellitus (IDDM).
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, axon. Cell junction, synapse. Cell membrane; Single-pass type I membrane protein. Endosome.; [ICA512-transmembrane fragment]: Cytoplasmic vesicle, secretory vesicle membrane.; [ICA512-cleaved cytosolic fragment]: Nucleus.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 8 subfamily
  • 組織特異性：
    Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.
  • 數據庫鏈接：

    HGNC: 9676

    OMIM: 601773

    KEGG: hsa:5798

    STRING: 9606.ENSP00000295718

    UniGene: Hs.89655



主站蜘蛛池模板： 亚洲爆乳www无码专区| a亚洲va欧美va国产综合| 18禁白丝喷水视频www视频| 全球av集中精品导航福利| 国产精品久久久久久亚洲影视| 国产精品成人嫩草影院| 在线观看的av免费网站| 欧美人与zoxxxx另类| 久久久久久午夜成人影院| 中文字幕乱码中文乱码51精品| 久久久亚洲欧洲日产国码606| 九九热爱视频精品| 69国产精品成人aaaaa片| 99re在线播放| 国产精品麻豆欧美日韩ww| 特级做a爰片毛片免费看108| 日本中文一二区有码在线| 亚洲最大的熟女水蜜桃av网站| 国产精品va在线观看无码不卡 | 欧美精品亚洲精品日韩传电影 | 男女啪啪无遮挡免费网站| 羞羞影院午夜男女爽爽| 朝鲜女人大白屁股ass孕交| 毛片无码一区二区三区a片视频| 亚洲综合在线另类色区奇米| 麻豆果冻精东九一传媒mv| 最新中文乱码字字幕在线| 国产色爱av资源综合区| 丰满少妇人妻久久久久久| 国产线观看免费观看| 日韩人妻少妇一区二区三区| 国产精品中文久久久久久久| 国产国语老龄妇女a片| 国产精品原创巨作av女教师| 亚洲色偷偷偷网站色偷一区| 怡红院av亚洲一区二区三区h| 成人毛片一区二区| 亚洲午夜久久久久妓女影院| 亚洲人成电影网站在线播放| 激情五月婷婷| 国产aⅴ激情无码久久久无码|