在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PTPN3 Antibody

PTPN3 Antibody

  • 中文名稱：
    PTPN3兔多克隆抗體
  • 貨號：
    CSB-PA019040LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA019040LA01HU diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA019040LA01HU diluted at 1:600 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA019040LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PTPN3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PTPN3
  • 別名：
    cytoskeletal-associated protein tyrosine phosphatase antibody; protein tyrosine phosphatase H1 antibody; protein tyrosine phosphatase non-receptor type 3 antibody; Protein-tyrosine phosphatase H1 antibody; PTN3_HUMAN antibody; PTP-H1 antibody; PTPH1 antibody; PTPN3 antibody; Tyrosine-protein phosphatase non-receptor type 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 3 protein (365-505AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PTPN3 Antibody (CSB-PA019040LA01HU)，的標記方式是Non-conjugated。對于PTPN3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA019040LB01HU PTPN3 Antibody, HRP conjugated ELISA
    FITC CSB-PA019040LC01HU PTPN3 Antibody, FITC conjugated
    Biotin CSB-PA019040LD01HU PTPN3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
  • 基因功能參考文獻：
    1. High expression of PTPN3 was significantly associated with unfavorable prognosis of GBM. Moreover, in GBM cell lines, PTPN3 promoted cell proliferation and invasion, and the PTP common inhibitor pervanadate suppressed GBM proliferation and invasion. PMID: 30348936
    2. PTPN3 promotes tumorigenicity, stemness and drug resistance in ovarian cancer. PMID: 27833130
    3. Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR) signaling. PMID: 25263444
    4. analysis of how allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation PMID: 25314968
    5. These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1. PMID: 24227889
    6. Activating mutations in and high expression levels of PTPN3 were associated with tumor recurrence in cholangiocarcinoma. PMID: 24503127
    7. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. PMID: 22730326
    8. The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced. PMID: 22334442
    9. PTPH1 stimulated breast cancer growth through regulating vitamin D receptor expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis. PMID: 21119599
    10. PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma-binding activity. Ras increases p38gamma and PTPH1 expression and there is a coupling of increased p38gamma and PTPH1 protein expression in colon cancer. PMID: 20332238
    11. regulates TACE (tnf-alpha convertase} PMID: 12207026
    12. first reported demonstration that protein tyrosine phosphatase H1(PTPH1) is capable of interacting with and dephosphorylating T cell receptor zeta subunit PMID: 14672952
    13. PTPH1 binds to the PDZ-domain binding motif of the cardiac voltage-gated sodium channel Na(v)1 and regulates the activity of Na(v)1. PMID: 16930557
    14. Degradation of PTPN3 by HPV-16 E6 requires E6AP, the proteasome, and an interaction between the carboxy terminus of E6 and the PDZ domain of PTPN3. PMID: 17166906
    15. phosphatase activity and FERM domain of PTPN3 are essential for its suppression of HBV gene expression. PMID: 17588219
    16. PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion PMID: 17921143
    17. Data suggest that reducing the level of PTPH1 may contribute to the oncogenic activity of high-risk genital E6 proteins. PMID: 17947517

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 數據庫鏈接：

    HGNC: 9655

    OMIM: 176877

    KEGG: hsa:5774

    STRING: 9606.ENSP00000363667

    UniGene: Hs.436429



主站蜘蛛池模板： 亚洲国产成人久久综合三区| 好男人社区在线www| 久久午夜夜伦鲁鲁片免费无码| 99久久久无码国产精品免费| 国产成人无码免费视频97| 欧美亚洲熟妇一区二区三区| 潮喷失禁大喷水aⅴ无码| 久久人妻无码一区二区| 亚洲伊人久久综合成人| 欧美老妇疯狂xxxxbbbb| 特级毛片内射www无码| 97午夜理论片在线影院| 最新的国产成人精品2022| 高清无码爆乳潮喷在线观看| 无码成a毛片免费| 国产成人精品2021| 亚洲国产成人av网站| 久久精品娱乐亚洲领先| 2024av天堂手机在线观看| 无码少妇精品一区二区免费动态| 亚洲区小说区激情区图片区| 亚洲乱妇亚洲乱妇xinglu| 欧美另类videosbestsex日本| 亚洲va久久久噜噜噜久久4399| 人妻少妇无码精品专区| 天堂网在线观看| 99久久综合狠狠综合久久止| 久久综合九色综合欧美就去吻| 亚洲日本乱码中文在线电影| 天堂www中文在线资源| 国产大屁股视频免费区| 亚洲色欲色欲77777小说网站| 国产又黄又爽又色的免费视频| 亚洲第一se情网站| 99精品视频一区在线观看| 最近更新中文字幕免费大全| 亚洲精品乱码久久久久久蜜桃图片| 51社区精品视频| 久久精品人人做人人爽97| 亚洲精品国产suv| 亚洲国产成人av片在线播放|