在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PTPN3 Antibody

PTPN3 Antibody

  • 中文名稱：
    PTPN3兔多克隆抗體
  • 貨號：
    CSB-PA019040LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA019040LA01HU diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA019040LA01HU diluted at 1:600 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA019040LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PTPN3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PTPN3
  • 別名：
    cytoskeletal-associated protein tyrosine phosphatase antibody; protein tyrosine phosphatase H1 antibody; protein tyrosine phosphatase non-receptor type 3 antibody; Protein-tyrosine phosphatase H1 antibody; PTN3_HUMAN antibody; PTP-H1 antibody; PTPH1 antibody; PTPN3 antibody; Tyrosine-protein phosphatase non-receptor type 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 3 protein (365-505AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PTPN3 Antibody (CSB-PA019040LA01HU)，的標記方式是Non-conjugated。對于PTPN3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA019040LB01HU PTPN3 Antibody, HRP conjugated ELISA
    FITC CSB-PA019040LC01HU PTPN3 Antibody, FITC conjugated
    Biotin CSB-PA019040LD01HU PTPN3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
  • 基因功能參考文獻：
    1. High expression of PTPN3 was significantly associated with unfavorable prognosis of GBM. Moreover, in GBM cell lines, PTPN3 promoted cell proliferation and invasion, and the PTP common inhibitor pervanadate suppressed GBM proliferation and invasion. PMID: 30348936
    2. PTPN3 promotes tumorigenicity, stemness and drug resistance in ovarian cancer. PMID: 27833130
    3. Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR) signaling. PMID: 25263444
    4. analysis of how allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation PMID: 25314968
    5. These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1. PMID: 24227889
    6. Activating mutations in and high expression levels of PTPN3 were associated with tumor recurrence in cholangiocarcinoma. PMID: 24503127
    7. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. PMID: 22730326
    8. The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced. PMID: 22334442
    9. PTPH1 stimulated breast cancer growth through regulating vitamin D receptor expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis. PMID: 21119599
    10. PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma-binding activity. Ras increases p38gamma and PTPH1 expression and there is a coupling of increased p38gamma and PTPH1 protein expression in colon cancer. PMID: 20332238
    11. regulates TACE (tnf-alpha convertase} PMID: 12207026
    12. first reported demonstration that protein tyrosine phosphatase H1(PTPH1) is capable of interacting with and dephosphorylating T cell receptor zeta subunit PMID: 14672952
    13. PTPH1 binds to the PDZ-domain binding motif of the cardiac voltage-gated sodium channel Na(v)1 and regulates the activity of Na(v)1. PMID: 16930557
    14. Degradation of PTPN3 by HPV-16 E6 requires E6AP, the proteasome, and an interaction between the carboxy terminus of E6 and the PDZ domain of PTPN3. PMID: 17166906
    15. phosphatase activity and FERM domain of PTPN3 are essential for its suppression of HBV gene expression. PMID: 17588219
    16. PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion PMID: 17921143
    17. Data suggest that reducing the level of PTPH1 may contribute to the oncogenic activity of high-risk genital E6 proteins. PMID: 17947517

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 數據庫鏈接：

    HGNC: 9655

    OMIM: 176877

    KEGG: hsa:5774

    STRING: 9606.ENSP00000363667

    UniGene: Hs.436429



主站蜘蛛池模板： 中文字幕无线观看不卡网站| 欧美国产成人精品一区二区三区| 久久久久久国产精品无码超碰| 日本大胆欧美人术艺术| 精品亚洲国产成人av在线时间短的| 国内精品伊人久久久久影院对白| 爆乳一区二区三区无码| 污污污污污污污网站污| 国产精品福利视频导航| 人妻体内射精一区二区三区| 人妻少妇被粗大爽9797pw| 呦男呦女视频精品八区| 九九热爱视频精品| 污污网站18禁在线永久免费观看| 国产黄在线观看免费观看软件| 国产欧美亚洲精品a| 伊人久久大香线蕉影院| 日韩一本之道一区中文字幕| 免费国产va在线观看中文字| 天天av天天爽无码中文| 热re99久久精品国产66热| 夜夜躁狠狠躁日日躁孕妇| 国产白丝精品爽爽久久蜜臀| 色偷偷www.8888在线观看| 日本又黄又爽又色又刺激的视频 | 人妻无码中字在线a| 夜夜春夜夜爽| 欧美成人精品第一区二区三区| 国产精久久一区二区三区| 无码国模产在线观看免费| 日韩无套内射高潮| 在线а√天堂中文官网| 久久人人爽爽爽人久久久| 国产又色又爽又黄又免费软件| 久久www免费人成人片| 精品一卡2卡三卡4卡乱码精品视频| 亚洲精品国产高清一线久久| 国产又滑又嫩又白| 高h纯肉无码视频在线观看| 亚洲va无码va在线va天堂| 国产精品美女久久久久久2021|