在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTPN3 Antibody

  • 中文名稱:
    PTPN3兔多克隆抗體
  • 貨號:
    CSB-PA104597
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA104597(PTPN3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA104597(PTPN3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PTPN3
  • 別名:
    cytoskeletal-associated protein tyrosine phosphatase antibody; protein tyrosine phosphatase H1 antibody; protein tyrosine phosphatase non-receptor type 3 antibody; Protein-tyrosine phosphatase H1 antibody; PTN3_HUMAN antibody; PTP-H1 antibody; PTPH1 antibody; PTPN3 antibody; Tyrosine-protein phosphatase non-receptor type 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human PTPN3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
  • 基因功能參考文獻:
    1. High expression of PTPN3 was significantly associated with unfavorable prognosis of GBM. Moreover, in GBM cell lines, PTPN3 promoted cell proliferation and invasion, and the PTP common inhibitor pervanadate suppressed GBM proliferation and invasion. PMID: 30348936
    2. PTPN3 promotes tumorigenicity, stemness and drug resistance in ovarian cancer. PMID: 27833130
    3. Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR) signaling. PMID: 25263444
    4. analysis of how allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation PMID: 25314968
    5. These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1. PMID: 24227889
    6. Activating mutations in and high expression levels of PTPN3 were associated with tumor recurrence in cholangiocarcinoma. PMID: 24503127
    7. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. PMID: 22730326
    8. The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced. PMID: 22334442
    9. PTPH1 stimulated breast cancer growth through regulating vitamin D receptor expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis. PMID: 21119599
    10. PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma-binding activity. Ras increases p38gamma and PTPH1 expression and there is a coupling of increased p38gamma and PTPH1 protein expression in colon cancer. PMID: 20332238
    11. regulates TACE (tnf-alpha convertase} PMID: 12207026
    12. first reported demonstration that protein tyrosine phosphatase H1(PTPH1) is capable of interacting with and dephosphorylating T cell receptor zeta subunit PMID: 14672952
    13. PTPH1 binds to the PDZ-domain binding motif of the cardiac voltage-gated sodium channel Na(v)1 and regulates the activity of Na(v)1. PMID: 16930557
    14. Degradation of PTPN3 by HPV-16 E6 requires E6AP, the proteasome, and an interaction between the carboxy terminus of E6 and the PDZ domain of PTPN3. PMID: 17166906
    15. phosphatase activity and FERM domain of PTPN3 are essential for its suppression of HBV gene expression. PMID: 17588219
    16. PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion PMID: 17921143
    17. Data suggest that reducing the level of PTPH1 may contribute to the oncogenic activity of high-risk genital E6 proteins. PMID: 17947517

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 數據庫鏈接:

    HGNC: 9655

    OMIM: 176877

    KEGG: hsa:5774

    STRING: 9606.ENSP00000363667

    UniGene: Hs.436429



主站蜘蛛池模板: 18禁裸体女免费观看| 国产公开免费人成视频| 女人被强╳到高潮喷水在线观看| 天堂√在线中文官网在线| 国产98色在线 | 国| 国产成人亚洲精品无码车a| 日本二区三区欧美亚洲国| 国产激情艳情在线看视频| 色婷婷久久一区二区三区麻豆 | 国产精品嫩草影院av| 色噜噜狠狼综合在线| 无码人妻少妇久久中文字幕蜜桃| 亚洲va韩国va欧美va| 国产最新进精品视频| 色妺妺av爽爽影院| 人妻系列无码一区二区三区| 后入到高潮免费观看| 丰满少妇女裸体bbw| 在线观看成人年视频免费 | 少妇又紧又深又湿又爽视频| 菠萝蜜视频在线观看入口| 人妻精品制服丝袜久久久| 在线a毛片免费视频观看| 66亚洲一卡2卡新区成片发布 | 99久热在线精品996热是什么| 7m精品福利视频导航| 无码少妇一区二区三区免费| 免费床视频大全叫不停欧美| 亂倫近親相姦中文字幕| 免费看又黄又爽又猛的视频软件| 无码综合天天久久综合网色吧影院| 最新国产在线拍揄自揄视频| 奇米精品视频一区二区三区| 色avav色av爱avav亚洲色拍| 两性色午夜视频免费无码| 国产精品户外野外| 青青草国产精品免费观看| 亚洲男人的天堂在线aⅴ视频| 亚洲人成电影网站色www两男一女| 中国xxxx做受视频| 日日碰狠狠躁久久躁9|