在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTPN14 Antibody

  • 中文名稱:
    PTPN14兔多克隆抗體
  • 貨號:
    CSB-PA019028GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PTPN14
  • 別名:
    Cytoskeletal associated protein tyrosine phosphatase antibody; MGC126803 antibody; PEZ antibody; Phosphatase with ezrin domain antibody; Protein tyrosine phosphatase non receptor type 14 antibody; Protein tyrosine phosphatase pez antibody; Protein-tyrosine phosphatase pez antibody; PTN14_HUMAN antibody; PTP 36 antibody; PTP36 antibody; PTPD 2 antibody; PTPN 14 antibody; PTPN14 antibody; Tyrosine protein phosphatase non receptor type 14 antibody; Tyrosine-protein phosphatase non-receptor type 14 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PTPN14
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
  • 基因功能參考文獻:
    1. p53 deficiency promotes Yap signaling and that PTPN14 and TP53 mutations are mutually exclusive in human cancers. PMID: 29017057
    2. study determined that high-risk E7 proteins target the proteolysis of the cellular protein tyrosine phosphatase PTPN14 and find that this activity is correlated with the retinoblastoma-independent transforming activity of E7 PMID: 27651363
    3. PTPN14 is classified as a potential tumor suppressor protein, and is very susceptible to HPV E7-induced proteasome-mediated degradation. PMID: 28100625
    4. The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 was responsible for the pathway association (P < 0.01),corrected P = 0.02). rs142697907 in PTPN14 was associated with ER-positive breast cancer and rs2456773 in CDK1 with ER-negativity in case-only analysis after gene-level correction PMID: 27485598
    5. PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells. PMID: 25814387
    6. Findings indicate a pathway involving protein-tyrosine phosphatase D2 PTPD2 (PTPN14) and the lipid second messenger phosphatidic acid that promotes ERBB2 receptor function. PMID: 25681440
    7. results indicate a potential regulatory role of PTPN14 in the Hippo pathway and demonstrate another layer of regulation in the YAP oncogenic function PMID: 25023289
    8. Data demonstrate that PTPN14 downregulation can phenocopy YAP activation in mammary epithelial cells and synergize with YAP to induce oncogenic transformation. PMID: 23613971
    9. Data show that p130 Crk-associated substrate is a direct substrate of PTPN14 and that PTPN14 specifically regulates p130Cas phosphorylation at tyrosine residue 128 in colorectal cancer cells. PMID: 22710723
    10. YAP is a direct substrate of PTPN14. Results indicate a potential regulatory role of PTPN14 on YAP and demonstrate a novel mechanism in YAP regulation. PMID: 22525271
    11. YAP forms a protein complex with PTPN14 through the WW domains of YAP and the PPXY motifs of PTPN14. PMID: 22689061
    12. that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1 PMID: 22948661
    13. PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1 PMID: 22233626
    14. These results suggest a unique and conserved role for PTPN14 in the regulation of lymphatic development in mammals and a nonconserved role in choanal development in humans. PMID: 20826270
    15. results provide a high-resolution crystal structure of the phosphatase PTPN14, thereby providing insight into its distinct substrate specificity and identifying unique structural features PMID: 16534812
    16. Dysregulation of TGFbeta signaling as a possible link between Pez mutation and cancer progression. PMID: 18677119

    顯示更多

    收起更多

  • 相關疾病:
    Choanal atresia and lymphedema (CHATLY)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 9647

    OMIM: 603155

    KEGG: hsa:5784

    STRING: 9606.ENSP00000355923

    UniGene: Hs.193557



主站蜘蛛池模板: 日本肥老妇色xxxxx日本老妇| 久久精品亚洲中文字幕无码麻豆| 国产边摸边吃奶边叫做激情视频| 1000部夫妻午夜免费| 精品一区二区不卡无码av| 国产+日韩+另类+视频一区| 国产日韩精品视频无码| 老头边吃奶边弄进去呻吟| 国产福利一区二区三区在线观看| 亚洲欧美日韩中文字幕在线一区| 日韩精品专区在线影院重磅| 国产日韩在线视看第一页| 一区二区三区人妻无码| 欧美品无码一区二区三区在线蜜桃| 99久热国产精品视频尤物| 久久这里精品国产99丫e6| 人人妻人人爽人人做夜欢视频 | 无码日韩精品一区二区人妻| 欧美巨波霸乳影院| 好男人www社区视频在线资源| 国产99视频精品免费视看6| 麻豆高清免费国产一区| 亚洲精品国产电影| 亚洲国产成人久久综合同性 | 中文有码无码人妻在线| 亚洲 日韩 欧美 成人 在线观看| 色综合视频一区中文字幕| 亚洲a∨无码国产精品久久网| 西欧free性满足hd老熟妇| 日韩 欧美 国产 一区三| 无码日韩人妻av一区免费| 国产a∨精品一区二区三区不卡| 色欲久久久天天天综合网| 色欲天天天综合网| 久久香蕉国产线看观看猫咪av| 国产精品自在在线午夜| 免费看美女部位隐私网站| 欧美视频专区一二在线观看| 久久99国产精品久久99果冻传媒| 超碰香蕉人人网99精品| 久热这里只有精品99|