在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTPN14 Antibody, Biotin conjugated

  • 中文名稱:
    PTPN14兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA623010LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PTPN14 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PTPN14
  • 別名:
    Cytoskeletal associated protein tyrosine phosphatase antibody; MGC126803 antibody; PEZ antibody; Phosphatase with ezrin domain antibody; Protein tyrosine phosphatase non receptor type 14 antibody; Protein tyrosine phosphatase pez antibody; Protein-tyrosine phosphatase pez antibody; PTN14_HUMAN antibody; PTP 36 antibody; PTP36 antibody; PTPD 2 antibody; PTPN 14 antibody; PTPN14 antibody; Tyrosine protein phosphatase non receptor type 14 antibody; Tyrosine-protein phosphatase non-receptor type 14 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 protein (220-351AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
  • 基因功能參考文獻:
    1. p53 deficiency promotes Yap signaling and that PTPN14 and TP53 mutations are mutually exclusive in human cancers. PMID: 29017057
    2. study determined that high-risk E7 proteins target the proteolysis of the cellular protein tyrosine phosphatase PTPN14 and find that this activity is correlated with the retinoblastoma-independent transforming activity of E7 PMID: 27651363
    3. PTPN14 is classified as a potential tumor suppressor protein, and is very susceptible to HPV E7-induced proteasome-mediated degradation. PMID: 28100625
    4. The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 was responsible for the pathway association (P < 0.01),corrected P = 0.02). rs142697907 in PTPN14 was associated with ER-positive breast cancer and rs2456773 in CDK1 with ER-negativity in case-only analysis after gene-level correction PMID: 27485598
    5. PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells. PMID: 25814387
    6. Findings indicate a pathway involving protein-tyrosine phosphatase D2 PTPD2 (PTPN14) and the lipid second messenger phosphatidic acid that promotes ERBB2 receptor function. PMID: 25681440
    7. results indicate a potential regulatory role of PTPN14 in the Hippo pathway and demonstrate another layer of regulation in the YAP oncogenic function PMID: 25023289
    8. Data demonstrate that PTPN14 downregulation can phenocopy YAP activation in mammary epithelial cells and synergize with YAP to induce oncogenic transformation. PMID: 23613971
    9. Data show that p130 Crk-associated substrate is a direct substrate of PTPN14 and that PTPN14 specifically regulates p130Cas phosphorylation at tyrosine residue 128 in colorectal cancer cells. PMID: 22710723
    10. YAP is a direct substrate of PTPN14. Results indicate a potential regulatory role of PTPN14 on YAP and demonstrate a novel mechanism in YAP regulation. PMID: 22525271
    11. YAP forms a protein complex with PTPN14 through the WW domains of YAP and the PPXY motifs of PTPN14. PMID: 22689061
    12. that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1 PMID: 22948661
    13. PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1 PMID: 22233626
    14. These results suggest a unique and conserved role for PTPN14 in the regulation of lymphatic development in mammals and a nonconserved role in choanal development in humans. PMID: 20826270
    15. results provide a high-resolution crystal structure of the phosphatase PTPN14, thereby providing insight into its distinct substrate specificity and identifying unique structural features PMID: 16534812
    16. Dysregulation of TGFbeta signaling as a possible link between Pez mutation and cancer progression. PMID: 18677119

    顯示更多

    收起更多

  • 相關疾病:
    Choanal atresia and lymphedema (CHATLY)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9647

    OMIM: 603155

    KEGG: hsa:5784

    STRING: 9606.ENSP00000355923

    UniGene: Hs.193557



主站蜘蛛池模板: 国产sm鞭打折磨调教视频 | 日韩精品无码一区二区三区| 精品国产麻豆免费人成网站| 亚洲成av人片天堂网老年人| 久久人搡人人玩人妻精品| 国产精品a无线| 老熟妻内射精品一区| 国内精品乱码卡一卡2卡麻豆| 亚洲欧美不卡高清在线| 亚洲色欲色欲www| 国产免费无码一区二区| 亚洲2020天天堂在线观看| 7777久久久国产精品消防器材| 高中生自慰www网站| 不卡无码av一区二区三区 | 97视频精品全国免费观看| 日本真人边吃奶边做爽免费视频 | 国内丰满熟女出轨videos| 成人女人看片免费视频放人| 亚洲伊人色欲综合网| 奇米综合四色77777久久| 欧美日产国产精品日产| 久久人妻少妇嫩草av无码专区| 少妇高潮无套内谢| 动漫av纯肉无码免费播放| 国产成人精品一区二区三区无码| 噜噜噜亚洲色成人网站| 成人精品视频在线观看不卡| 中国老妇xxxx性开放| 久久中文字幕人妻熟av女蜜柚m| 日韩av无码成人无码免费| 国产公开久久人人97超碰| 夜夜躁很很躁日日躁麻豆 | 亚洲精品一品区二品区三区| 护士奶头又大又软又好摸| 人妻丰满熟妇av无码区乱| 久久中文字幕人妻丝袜| 国产在线清纯极品美女援交| 国产精品99精品久久免费| 美女张开腿黄网站免费下载| 国内精品乱码卡一卡2卡|