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PTGR2 Antibody

  • 中文名稱:
    PTGR2兔多克隆抗體
  • 貨號:
    CSB-PA234635
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HUVEC cells, K562 cells and HT-29 cells, using ZADH1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PTGR2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PTGR2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human ZADH1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
  • 基因功能參考文獻:
    1. Silencing of PTGR2 expression enhances reactive oxygen species production, suppresses pancreatic cell proliferation, and promotes cell death through increasing 15-keto-PGE2. PMID: 26820738
    2. Functional data and clinical relevance for the role of PTGR2 in gastric cancer, are provided. PMID: 22998775
    3. Cloning and tissue distribution of a splicing variant ZADH1b. PMID: 15004468
    4. Besides targeting cyclooxygenase, indomethacin inhibits PTGR2 with a binding mode similar to that of 15-keto-PGE(2). PMID: 19000823
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    NADP-dependent oxidoreductase L4BD family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 20149

    OMIM: 608642

    KEGG: hsa:145482

    STRING: 9606.ENSP00000267568

    UniGene: Hs.632344



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