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  4. PSMC4 Antibody

PSMC4 Antibody

  • 中文名稱：
    PSMC4兔多克隆抗體
  • 貨號：
    CSB-PA018894LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue
      All lanes: PSMC4 antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 48, 44 kDa
      Observed band size: 48 kDa
    • IHC image of CSB-PA018894LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA018894LA01HU diluted at 1:500 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PSMC4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PSMC4
  • 別名：
    26S protease regulatory subunit 6B antibody; 26S proteasome AAA ATPase subunit RPT3 antibody; 26S proteasome AAA-ATPase subunit RPT3 antibody; MB67 interacting protein antibody; MB67-interacting protein antibody; MIP224 antibody; Protease 26S subunit 6 antibody; Proteasome (prosome macropain) 26S subunit ATPase 4 antibody; Proteasome 19S S6 antibody; Proteasome 26S subunit ATPase 4 antibody; Proteasome 26S subunit; ATPase; 4 antibody; PRS6B_HUMAN antibody; PSMC4 antibody; RPT3 antibody; S6 antibody; Tat binding protein 7 antibody; TAT-binding protein 7 antibody; TBP 7 antibody; TBP-7 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human 26S proteasome regulatory subunit 6B protein (112-181AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PSMC4 Antibody (CSB-PA018894LA01HU)，的標記方式是Non-conjugated。對于PSMC4 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA018894LB01HU PSMC4 Antibody, HRP conjugated ELISA
    FITC CSB-PA018894LC01HU PSMC4 Antibody, FITC conjugated
    Biotin CSB-PA018894LD01HU PSMC4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能參考文獻：
    1. This study demonstrated that particular distribution for HSC70 and PSMC4 in the cytoplasm and accumulation within Lewy body in the dopaminergic neurons of the substantia nigra in Parkinson patients. PMID: 29218503
    2. Structural mechanism for nucleotide-driven remodeling of RPT3 and its homologs in the activated human 26S proteasome has been reported. PMID: 29636472
    3. Site-specific Rpt3 phosphorylation by DYRK2 controls cell proliferation and tumorigenesis in breast neoplasms. PMID: 26655835
    4. Saquinavir-NO inhibits activation of S6 protein in androgen-dependent prostate cancer cells. PMID: 22370480
    5. The proposed TRAP1 network has an impact in vivo, as it is conserved in human colorectal cancers, is controlled by ER-localized TRAP1 interacting with TBP7 and provides a novel model of the ER-mitochondria crosstalk. PMID: 21979464
    6. C terminus of Rpt3, an ATPase subunit of PA700 (19 S) regulatory complex, is essential for 26 S proteasome assembly but not for activation PMID: 20937828
    7. interacts with gankyrin through C-terminal 78 amino acids PMID: 11779854
    8. a novel specific interaction of synphilin-1 with the regulatory proteasomal protein S6 ATPase (tbp7) in aggresome-like intracytoplasmic inclusions PMID: 17327361
    9. An insertion/deletion variant in intron 5 of the S6 ATPase gene was more frequent in German Parkinson's disease patients compared to controls PMID: 18446261

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AAA ATPase family
  • 數據庫鏈接：

    HGNC: 9551

    OMIM: 602707

    KEGG: hsa:5704

    STRING: 9606.ENSP00000157812

    UniGene: Hs.211594



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