在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PSMB5 Antibody

PSMB5 Antibody

  • 中文名稱：
    PSMB5兔多克隆抗體
  • 貨號：
    CSB-PA010083LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse lung tissue
      All lanes: PSMB5 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 29, 22, 18 kDa
      Observed band size: 29 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010083LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010083LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA010083LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PSMB5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PSMB5
  • 別名：
    DKFZp459C139 antibody; EC 3.4.25.1 antibody; LMPX antibody; Macropain epsilon chain antibody; MB1 antibody; MGC104214 antibody; MGC118075 antibody; MGC134464 antibody; Multicatalytic endopeptidase complex epsilon chain antibody; Proteasome (prosome, macropain) subunit, beta type, 5 antibody; Proteasome beta 5 subunit antibody; Proteasome catalytic subunit 3 antibody; Proteasome chain 6 antibody; Proteasome epsilon chain antibody; Proteasome subunit beta type-5 antibody; Proteasome subunit MB1 antibody; Proteasome subunit X antibody; Proteasome subunit, beta type, 5 antibody; Proteasome subunit, beta-5 antibody; PSB5_HUMAN antibody; PSMB5 antibody; PSX large multifunctional protease X antibody; X antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Proteasome subunit beta type-5 protein (106-188AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PSMB5 Antibody (CSB-PA010083LA01HU)，的標記方式是Non-conjugated。對于PSMB5 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA010083LB01HU PSMB5 Antibody, HRP conjugated ELISA
    FITC CSB-PA010083LC01HU PSMB5 Antibody, FITC conjugated
    Biotin CSB-PA010083LD01HU PSMB5 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
  • 基因功能參考文獻：
    1. Our results suggest a potential role for PSMB5 as a biomarker and therapeutic target for Triple-negative breast cancer PMID: 28623645
    2. Results identified PSMB5 Q62P mutation to underlie bortezomib resistance in Down-syndrome-associated acute myeloid leukemia cells. PMID: 28143565
    3. Data indicate that proteasomal subunit X PSMB5 is a target of signal transducer and activator of transcription 3 (STAT3). PMID: 24627483
    4. Nuclear MB1 expression was an independent predictor of worse survival in ovarian cancer. PMID: 19243813
    5. critical role of PSMB5 in 20S proteasome-mediated protection against replicative senescence, pointing to a possible strategy for maintaining the integrity of culture-expanded bone marrow stromal cells by manipulating the expression of PSMB5 PMID: 24393841
    6. The expression of proteasome beta5 decreases markedly in human atherosclerotic plaques. PMID: 22781773
    7. Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10. PMID: 23018640
    8. Letter/Case Reports: proteasome subunit beta5t is expressed in cervical ectopic thymoma. PMID: 22523338
    9. PSMB5 overexpression is associated with Bortezomib resistance in myeloma. PMID: 21978467
    10. No mutations or differences in PSMB5 mRNA expression were seen before bortezomib treatment in 3 multiple myeloma patients, but after treatment, 1 patient showed PSMB5 upregulation associated with bortezomib resistance. PMID: 21920470
    11. CDK5 regulation of proteasome subunit PSMB5 was identified as a probable route to antineoplastic drug sensitization. PMID: 21289309
    12. Expression of mutated PSMB5 was associated with the prevention of the accumulation of unfolded proteins PMID: 20555361
    13. interaction of TAP1 and TAP2 and P-glycoprotein with proteasome subunits beta-5 and beta-5i suggest direct targeting of antigenic peptides to the ER via a TAP-proteasome association and a possible role for P-glycoprotein PMID: 15488952
    14. Proteasome activity can be genetically "upregulated" in lens cells by overexpression of beta5 catalytic subunit. Resulting increase in proteasome activity leads to decrease in oxidized proteins and enhanced cell survival following oxidative stress. PMID: 17262013
    15. G322A mutation of the PSMB5 gene is a novel mechanism for bortezomib resistance. PMID: 18502982
    16. nonsynonymous coding single nucleotide polymorphismsin the proteasome beta 5 subunit gene did not show significant effects on proteasome activity, but SNPs did influence transcription PMID: 18519783
    17. Overexpression of PSMB5 is an important mechanism for bortezomib resistance in Jurkat cell lines. PMID: 18562081
    18. a novel mechanism of bortezomib resistance associated with the selective overexpression of a mutant PSMB5 protein PMID: 18565852
    19. Mutations of the PSMB5 gene resulting in substitutions of Ala49 and Ala50 of PSMB5 protein can confer varying bortezomib resistance PMID: 19426847

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 數據庫鏈接：

    HGNC: 9542

    OMIM: 600306

    KEGG: hsa:5693

    STRING: 9606.ENSP00000355325

    UniGene: Hs.422990



主站蜘蛛池模板： 1000部拍拍拍18勿入免费视频下载| 无码精品人妻一区二区三区免费看| 久久精品女人天堂av| 国产精品白丝av在线观看播放| 欧美激性欧美激情在线| 久久精品国产99久久久| 熟女人妻大叫粗大受不了| 久久久亚洲色| 无码中文字幕va精品影院| 三级男人添奶爽爽爽视频| 久久综合五月丁香六月丁香| 国产精品欧美福利久久| 亚洲卡一卡二卡三新区乱码| 少妇被又大又粗又爽毛片久久黑人| 国产精品亚洲欧美大片在线看| 欧美黑人与白人精品a片| 亚洲日韩中文字幕久热| 一本色道久久99一综合| 国产成a人亚洲精品无码樱花 | 久久亚洲精品情侣| 久久国产超碰女女av| 精品丰满人妻无套内射| 又污又爽又黄的网站| 四虎亚洲精品高清在线观看| 884aa四虎影成人精品| 亚洲日韩国产成网在线观看| 国产xxxx视频在线| 扒开双腿猛进入喷水高潮视频| 精品1卡二卡三卡四卡老狼| 女人18毛片水最多| 国产在线午夜不卡精品影院 | 久久精品中文字幕第一页| 综合亚洲另类欧美久久成人精品| 欧美私人情侣网站| 国产午夜福利在线播放87| 少妇愉情理伦片bd| 久久精品a亚洲国产v高清不卡 | 国产av亚洲精品ai换脸电影 | 亚洲一区二区三区尿失禁| 日本高清视频www夜色资源| 国产av毛片亚洲含羞草社|