在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PSMB5 Antibody, Biotin conjugated

PSMB5 Antibody, Biotin conjugated

  • 中文名稱：
    PSMB5兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA010083LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PSMB5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PSMB5
  • 別名：
    DKFZp459C139 antibody; EC 3.4.25.1 antibody; LMPX antibody; Macropain epsilon chain antibody; MB1 antibody; MGC104214 antibody; MGC118075 antibody; MGC134464 antibody; Multicatalytic endopeptidase complex epsilon chain antibody; Proteasome (prosome, macropain) subunit, beta type, 5 antibody; Proteasome beta 5 subunit antibody; Proteasome catalytic subunit 3 antibody; Proteasome chain 6 antibody; Proteasome epsilon chain antibody; Proteasome subunit beta type-5 antibody; Proteasome subunit MB1 antibody; Proteasome subunit X antibody; Proteasome subunit, beta type, 5 antibody; Proteasome subunit, beta-5 antibody; PSB5_HUMAN antibody; PSMB5 antibody; PSX large multifunctional protease X antibody; X antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Proteasome subunit beta type-5 protein (106-188AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
  • 基因功能參考文獻(xiàn)：
    1. Our results suggest a potential role for PSMB5 as a biomarker and therapeutic target for Triple-negative breast cancer PMID: 28623645
    2. Results identified PSMB5 Q62P mutation to underlie bortezomib resistance in Down-syndrome-associated acute myeloid leukemia cells. PMID: 28143565
    3. Data indicate that proteasomal subunit X PSMB5 is a target of signal transducer and activator of transcription 3 (STAT3). PMID: 24627483
    4. Nuclear MB1 expression was an independent predictor of worse survival in ovarian cancer. PMID: 19243813
    5. critical role of PSMB5 in 20S proteasome-mediated protection against replicative senescence, pointing to a possible strategy for maintaining the integrity of culture-expanded bone marrow stromal cells by manipulating the expression of PSMB5 PMID: 24393841
    6. The expression of proteasome beta5 decreases markedly in human atherosclerotic plaques. PMID: 22781773
    7. Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10. PMID: 23018640
    8. Letter/Case Reports: proteasome subunit beta5t is expressed in cervical ectopic thymoma. PMID: 22523338
    9. PSMB5 overexpression is associated with Bortezomib resistance in myeloma. PMID: 21978467
    10. No mutations or differences in PSMB5 mRNA expression were seen before bortezomib treatment in 3 multiple myeloma patients, but after treatment, 1 patient showed PSMB5 upregulation associated with bortezomib resistance. PMID: 21920470
    11. CDK5 regulation of proteasome subunit PSMB5 was identified as a probable route to antineoplastic drug sensitization. PMID: 21289309
    12. Expression of mutated PSMB5 was associated with the prevention of the accumulation of unfolded proteins PMID: 20555361
    13. interaction of TAP1 and TAP2 and P-glycoprotein with proteasome subunits beta-5 and beta-5i suggest direct targeting of antigenic peptides to the ER via a TAP-proteasome association and a possible role for P-glycoprotein PMID: 15488952
    14. Proteasome activity can be genetically "upregulated" in lens cells by overexpression of beta5 catalytic subunit. Resulting increase in proteasome activity leads to decrease in oxidized proteins and enhanced cell survival following oxidative stress. PMID: 17262013
    15. G322A mutation of the PSMB5 gene is a novel mechanism for bortezomib resistance. PMID: 18502982
    16. nonsynonymous coding single nucleotide polymorphismsin the proteasome beta 5 subunit gene did not show significant effects on proteasome activity, but SNPs did influence transcription PMID: 18519783
    17. Overexpression of PSMB5 is an important mechanism for bortezomib resistance in Jurkat cell lines. PMID: 18562081
    18. a novel mechanism of bortezomib resistance associated with the selective overexpression of a mutant PSMB5 protein PMID: 18565852
    19. Mutations of the PSMB5 gene resulting in substitutions of Ala49 and Ala50 of PSMB5 protein can confer varying bortezomib resistance PMID: 19426847

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9542

    OMIM: 600306

    KEGG: hsa:5693

    STRING: 9606.ENSP00000355325

    UniGene: Hs.422990



主站蜘蛛池模板： 加勒比色综合久久久久久久久| 狠狠色噜噜狠狠狠7777奇米| 午夜男女爽爽影院免费视频下载 | 亚洲精品无码久久久久久久| 国产亚洲精品a在线| 中文字幕v亚洲ⅴv天堂| 免费无码av片在线观看潮喷| 小小拗女性bbwxxxx国产| 中文字幕人妻丝袜成熟乱| 国产精品久久久久久52avav| 久久久久国色av免费看| 山东熟女啪啪哦哦叫| 男女爽爽午夜18污污影院| 999久久久无码国产精品| 欧美40老熟妇色xxxxx| 天天躁日日躁狠狠躁视频2021| 国产乱人伦av在线无码| 日韩 无码 偷拍 中文字幕| av中文无码乱人伦在线观看| 日日碰狠狠添天天爽超碰97| 2021久久国自产拍精品| 天堂www中文在线资源| 国产日韩精品一区二区三区在线 | 国产精品视频白浆免费视频| 日本公与熄乱理在线播放| 国产午夜鲁丝片av无码免费| av无码精品一区二区三区四区| 在线视频网站www色| 人妻被按摩师玩弄到潮喷| 国产精品国产三级国av | 亚洲欧美精品综合在线观看| 国产午夜福利内射青草| 无码国产69精品久久久久网站| 日韩人妻一区二区三区免费| 国产乱了真实在线观看| 欧美国产伦久久久久久久| 久久综合色老色| 成人动漫综合网| 国产69精品久久久久乱码免费 | 女人被狂爆到高潮免费视频 | 免费国产va在线观看中文字|