在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRPF3 Antibody

  • 中文名稱:
    PRPF3兔多克隆抗體
  • 貨號:
    CSB-PA018763GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PRPF3
  • 別名:
    hPrp3 antibody; HPRP3P antibody; Pre mRNA splicing factor 3 antibody; Pre-mRNA-splicing factor 3 antibody; Precursor mRNA-processing factor 3; S. crevisiae; homolog of antibody; PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) antibody; Prp3p antibody; PRPF3 antibody; PRPF3_HUMAN antibody; RP18 antibody; SNRNP90 antibody; U4/U6 small nuclear ribonucleoprotein PRP3 antibody; U4/U6 snRNP 90 kDa protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PRPF3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
  • 基因功能參考文獻:
    1. Results from whole-exome sequencing identified 2 variants c.1345C > G (p.R449G) and c.1532A > C (p.H511P) in PRPF3 which co-segregate with retinitis pigmentosa in two families respectively. PMID: 27886254
    2. SUMO conjugation plays a role during mRNA splicing processes including a role for Prp3 SUMOylation in U4/U6*U5 tri-snRNP formation and/or recruitment. PMID: 28379520
    3. RP-PRPF defects affect the stoichiometry of spliceosomal small nuclear RNAs. Mutant PRPF3 proteins stably associated with tri-snRNPs. PMID: 21378395
    4. A mutation in the PRPF3 gene is rare compared to other genes causing autosomal dominant retinitis pigmentosa. PMID: 20309403
    5. Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa. PMID: 11773002
    6. role in the recruitment of Hprp4p for the U4/U6 snRNP assembly PMID: 11971898
    7. Nine mutations, six of which are novel, in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31, causing adRP have been identified in the Spanish population. PMID: 12714658
    8. Free and complexed cyclophilin H have virtually identical conformations suggesting that the U4/U6-60K binding site is pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is unaffected by complex formation PMID: 12875835
    9. We conclude that the Thr494Met mutation in the HPRP3 gene causes ADRP in Japanese patients. This mutation was found in 1% of patients with ADRP in Japan PMID: 15085354
    10. PAP-1 interacted with Prp3p but not Prp31p in human cells and yeast, and the basic region of PAP-1 and the C-terminal region of Prp3p, regions beside spots found in retinitis pigmentosa mutations, were needed for binding PMID: 15541726
    11. splicing factor PRPF3 mutations cause retinal degeneration and form detrimental aggregates in photoreceptor cells PMID: 17517693
    12. Findings suggest that the loss of Hprp3p phosphorylation at Thr494 is a key step for initiating Thr494Met aberrant interactions within U4/U6 snRNP complex and these are likely linked to the retinitis pigmentosa type 18 phenotype. PMID: 17932117
    13. splicing activity is significantly influenced by the CK2-hPrp3p interaction PMID: 18026141
    14. TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha PMID: 18395097
    15. These data support the notion about individual roles for CK2alpha and CK2alpha' in the splicing process. PMID: 18553058
    16. The human HPRP3 gene, the orthologue of the yeast pre-mRNA splicing factor (PRP3) PMID: 11773002

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 18 (RP18)
  • 亞細胞定位:
    Nucleus. Nucleus speckle.
  • 組織特異性:
    Highly expressed in retina, liver, kidney and blood. Detected at lower levels in heart and brain.
  • 數據庫鏈接:

    HGNC: 17348

    OMIM: 601414

    KEGG: hsa:9129

    STRING: 9606.ENSP00000315379

    UniGene: Hs.11776



主站蜘蛛池模板: 国产69精品久久久久人妻| 国产99久久久久久免费看| 欧洲多毛裸体xxxxx| 四虎影视精品永久在线观看| 失禁潮痉挛潮喷av在线无码| 国产在线午夜不卡精品影院| 国产下药迷倒白嫩美女网站| 欧美性黑人极品hd| 国产乱子伦精品无码专区| 日韩一区二区在线观看视频| 男人a天堂手机在线版| 日本成熟少妇喷浆视频| 国产大学生粉嫩无套流白浆| 无码成人一区二区| 米奇影视第四色| av无码人妻无码男人的天堂| 国产成+人欧美+综合在线观看| 国产精品久久久久久52avav | 国产成人无码a区在线观看视频app | 精品国产乱码久久久久乱码| 久久激情五月丁香伊人| 久久无码精品一区二区三区| 少妇内射高潮福利炮| 欧美老妇牲交videos| 精品日本一区二区免费视频| 成人免费无码大片a毛片小说 | 女人国产香蕉久久精品| 少妇激情一区二区三区视频小说 | 一二三四区无产乱码1000集| 欧美老人巨大xxxx做受视频| 色天天天综合色天天| 久久天天躁夜夜躁狠狠85| 黑人巨大av无码专区| 激情内射亚洲一区二区三区爱妻| 日日摸日日添日日碰9学生露脸| 狠狠色噜噜狠狠狠狠色综合久av| 亚洲中文综合网五月俺也去| 中国丰满人妻videoshd| 无码一区二区三区中文字幕| 精品日本免费一区二区三区| 免费无码肉片在线观看|