在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRPF3 Antibody

  • 中文名稱:
    PRPF3兔多克隆抗體
  • 貨號:
    CSB-PA018763GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PRPF3
  • 別名:
    hPrp3 antibody; HPRP3P antibody; Pre mRNA splicing factor 3 antibody; Pre-mRNA-splicing factor 3 antibody; Precursor mRNA-processing factor 3; S. crevisiae; homolog of antibody; PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) antibody; Prp3p antibody; PRPF3 antibody; PRPF3_HUMAN antibody; RP18 antibody; SNRNP90 antibody; U4/U6 small nuclear ribonucleoprotein PRP3 antibody; U4/U6 snRNP 90 kDa protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PRPF3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
  • 基因功能參考文獻:
    1. Results from whole-exome sequencing identified 2 variants c.1345C > G (p.R449G) and c.1532A > C (p.H511P) in PRPF3 which co-segregate with retinitis pigmentosa in two families respectively. PMID: 27886254
    2. SUMO conjugation plays a role during mRNA splicing processes including a role for Prp3 SUMOylation in U4/U6*U5 tri-snRNP formation and/or recruitment. PMID: 28379520
    3. RP-PRPF defects affect the stoichiometry of spliceosomal small nuclear RNAs. Mutant PRPF3 proteins stably associated with tri-snRNPs. PMID: 21378395
    4. A mutation in the PRPF3 gene is rare compared to other genes causing autosomal dominant retinitis pigmentosa. PMID: 20309403
    5. Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa. PMID: 11773002
    6. role in the recruitment of Hprp4p for the U4/U6 snRNP assembly PMID: 11971898
    7. Nine mutations, six of which are novel, in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31, causing adRP have been identified in the Spanish population. PMID: 12714658
    8. Free and complexed cyclophilin H have virtually identical conformations suggesting that the U4/U6-60K binding site is pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is unaffected by complex formation PMID: 12875835
    9. We conclude that the Thr494Met mutation in the HPRP3 gene causes ADRP in Japanese patients. This mutation was found in 1% of patients with ADRP in Japan PMID: 15085354
    10. PAP-1 interacted with Prp3p but not Prp31p in human cells and yeast, and the basic region of PAP-1 and the C-terminal region of Prp3p, regions beside spots found in retinitis pigmentosa mutations, were needed for binding PMID: 15541726
    11. splicing factor PRPF3 mutations cause retinal degeneration and form detrimental aggregates in photoreceptor cells PMID: 17517693
    12. Findings suggest that the loss of Hprp3p phosphorylation at Thr494 is a key step for initiating Thr494Met aberrant interactions within U4/U6 snRNP complex and these are likely linked to the retinitis pigmentosa type 18 phenotype. PMID: 17932117
    13. splicing activity is significantly influenced by the CK2-hPrp3p interaction PMID: 18026141
    14. TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha PMID: 18395097
    15. These data support the notion about individual roles for CK2alpha and CK2alpha' in the splicing process. PMID: 18553058
    16. The human HPRP3 gene, the orthologue of the yeast pre-mRNA splicing factor (PRP3) PMID: 11773002

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 18 (RP18)
  • 亞細胞定位:
    Nucleus. Nucleus speckle.
  • 組織特異性:
    Highly expressed in retina, liver, kidney and blood. Detected at lower levels in heart and brain.
  • 數據庫鏈接:

    HGNC: 17348

    OMIM: 601414

    KEGG: hsa:9129

    STRING: 9606.ENSP00000315379

    UniGene: Hs.11776



主站蜘蛛池模板: 性欧美丰满熟妇xxxx性| 99精品丰满人妻无码a片| 国产草莓视频无码a在线观看| 亚洲男人最新版本天堂| 国产伦精品一区二区三区免费| 色欲精品国产一区二区三区av| 全部露出来毛走秀福利视频| 粉嫩大学生无套内射无码卡视频 | 熟女人妻aⅴ一区二区三区60路 | 日本亚洲色大成网站www久久| 国产精品乱码一区二区三区| 制服视频在线一区二区| 亚洲一区二区三区在线网址| 波多野结衣不打码视频| 在线观看的网站| 天堂8а√中文在线官网| 韩国精品视频一区二区在线播放| 亚洲爆乳大丰满无码专区| 婷婷久久香蕉五月综合| 日韩欧美偷拍高跟鞋精品一区| 又粗又大又黄又爽的免费视频| 国产无套内射普通话对白| 国产av一区二区三区无码野战| 又色又爽又黄又无遮挡的网站| 国产无套精品一区二区三区| 国产女人高潮视频在线观看| 日韩免费一区二区三区高清| 亚洲欧美成人一区二区在线电影| 人妻少妇69式99偷拍| 国产在线视频天天综合网| 国产很色很黄很大爽的视频| 九九久久精品无码专区| 免费视频爱爱太爽了激情| 国语对白嫖老妇胖老太| 亚洲中文字幕无码不卡电影| 久久久无码人妻精品无码| 国产ktv交换配乱婬视频| 国产精品喷浆| 国产99在线 | 中文| 中文字幕精品视频在线看免费 | 欧美三级欧美成人高清|