在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRPF3 Antibody, Biotin conjugated

  • 中文名稱:
    PRPF3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA018763LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PRPF3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PRPF3
  • 別名:
    hPrp3 antibody; HPRP3P antibody; Pre mRNA splicing factor 3 antibody; Pre-mRNA-splicing factor 3 antibody; Precursor mRNA-processing factor 3; S. crevisiae; homolog of antibody; PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) antibody; Prp3p antibody; PRPF3 antibody; PRPF3_HUMAN antibody; RP18 antibody; SNRNP90 antibody; U4/U6 small nuclear ribonucleoprotein PRP3 antibody; U4/U6 snRNP 90 kDa protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human U4/U6 small nuclear ribonucleoprotein Prp3 protein (1-200AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
  • 基因功能參考文獻:
    1. Results from whole-exome sequencing identified 2 variants c.1345C > G (p.R449G) and c.1532A > C (p.H511P) in PRPF3 which co-segregate with retinitis pigmentosa in two families respectively. PMID: 27886254
    2. SUMO conjugation plays a role during mRNA splicing processes including a role for Prp3 SUMOylation in U4/U6*U5 tri-snRNP formation and/or recruitment. PMID: 28379520
    3. RP-PRPF defects affect the stoichiometry of spliceosomal small nuclear RNAs. Mutant PRPF3 proteins stably associated with tri-snRNPs. PMID: 21378395
    4. A mutation in the PRPF3 gene is rare compared to other genes causing autosomal dominant retinitis pigmentosa. PMID: 20309403
    5. Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa. PMID: 11773002
    6. role in the recruitment of Hprp4p for the U4/U6 snRNP assembly PMID: 11971898
    7. Nine mutations, six of which are novel, in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31, causing adRP have been identified in the Spanish population. PMID: 12714658
    8. Free and complexed cyclophilin H have virtually identical conformations suggesting that the U4/U6-60K binding site is pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is unaffected by complex formation PMID: 12875835
    9. We conclude that the Thr494Met mutation in the HPRP3 gene causes ADRP in Japanese patients. This mutation was found in 1% of patients with ADRP in Japan PMID: 15085354
    10. PAP-1 interacted with Prp3p but not Prp31p in human cells and yeast, and the basic region of PAP-1 and the C-terminal region of Prp3p, regions beside spots found in retinitis pigmentosa mutations, were needed for binding PMID: 15541726
    11. splicing factor PRPF3 mutations cause retinal degeneration and form detrimental aggregates in photoreceptor cells PMID: 17517693
    12. Findings suggest that the loss of Hprp3p phosphorylation at Thr494 is a key step for initiating Thr494Met aberrant interactions within U4/U6 snRNP complex and these are likely linked to the retinitis pigmentosa type 18 phenotype. PMID: 17932117
    13. splicing activity is significantly influenced by the CK2-hPrp3p interaction PMID: 18026141
    14. TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha PMID: 18395097
    15. These data support the notion about individual roles for CK2alpha and CK2alpha' in the splicing process. PMID: 18553058
    16. The human HPRP3 gene, the orthologue of the yeast pre-mRNA splicing factor (PRP3) PMID: 11773002

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Retinitis pigmentosa 18 (RP18)
  • 亞細胞定位:
    Nucleus. Nucleus speckle.
  • 組織特異性:
    Highly expressed in retina, liver, kidney and blood. Detected at lower levels in heart and brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17348

    OMIM: 601414

    KEGG: hsa:9129

    STRING: 9606.ENSP00000315379

    UniGene: Hs.11776



主站蜘蛛池模板: 国产高清在线精品一区| 国产拍揄自揄精品视频| 亚洲精品国产自在现线看| 国产精品三级av三级av三级| 熟妇的奶头又大又长奶水视频| 日日碰狠狠添天天爽无码| 国产精品无码无需播放器| 无码专区—va亚洲v天堂麻豆| 亚洲伊人成无码综合影院| 国产偷国产偷亚洲高清app| 中文字幕人成无码人妻| 日韩av无码国产精品| 四十如虎的丰满熟妇啪啪| 欧美熟妇性xxxx欧美熟人多毛| 国产黄大片在线观看画质优化 | 精品久久久久久无码专区| 日本国产成人国产在线播放| 久久青青草免费线频观| 国产免费又爽又色又粗视频| 精品无人区卡一卡二卡三乱码| 国产精品亚洲а∨天堂免下载| 久久国产人妻一区二区免费| 免费无码一区二区三区a片百度 | 情欲少妇人妻100篇| 国精品无码av人妻受辱系| 麻豆果冻传媒2021精品传媒一区下载| 亚洲 欧美 日韩 国产综合 在线| 新狼窝色av性久久久久久| 92国产精品午夜免费福利视频| 日韩一区二区三免费高清| 国产精品久久久久aaaa| 欧美巨大另类极品videosbest| 色伊人亚洲综合网站| 亚洲一本一道一区二区三区| 黑人巨大精品欧美| 天天躁日日躁狠狠躁| 中文字幕亚洲男人的天堂网络| 欧美三级a做爰在线观看| 日本高清www午色夜com| 亚洲男人片片在线观看| 国产性色αv视频免费|