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  4. PRND Antibody

PRND Antibody

  • 中文名稱：
    PRND兔多克隆抗體
  • 貨號：
    CSB-PA890741ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Prion-like protein doppel antibody at 2μg/ml + Mouse spleen tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 20 kDa
      Observed band size: 20 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890741ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PRND Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    dJ1068H6.4 antibody; DPL antibody; Dublet antibody; MGC41841 antibody; Prion gene complex downstream antibody; Prion like protein doppel antibody; Prion protein 2 (dublet) antibody; Prion protein 2 antibody; Prion-like protein doppel antibody; PRND antibody; PRND_HUMAN antibody; PrPLP antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Prion-like protein doppel protein (20-160AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+).
  • 基因功能參考文獻：
    1. results demonstrate that blocking doppel can control VEGF signaling in TECs and selectively inhibit tumor angiogenesis. PMID: 26950422
    2. The association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with Alzheimer's disease and mild cognitive impairment, was evaluated. PMID: 22453181
    3. in astrocytomas, Dpl undergoes different molecular processes that might constitute additional helpful tools to characterize the glial tumor progression PMID: 20981146
    4. Cytotoxicity induced by the expression of Dpl and truncated PrP in neural derived cells are closely related with the apoptosis process. PMID: 19728151
    5. expression pattern and biochemical characteristics in human tissues and in Chinese hamster ovary cells transfected with wild-type or variant human Dpl gene constructs PMID: 12200435
    6. Doppel expression is not modified in the brains of patients with Creutzfeldt-Jakob disease. PMID: 12586339
    7. human Doppel fails to interact with itself; Dpl and PrP are not related or are only marginally related with respect to their ligand binding behaviour PMID: 15158907
    8. results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane PMID: 15203115
    9. Doppel interacts with the full-length laminin receptor precursor protein PMID: 15246873
    10. Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells. Doppel may play a physiological role in acrosome biogenesis. PMID: 16421231
    11. Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes. PMID: 17390034
    12. Study provides the foundation for further study of Dpl biological functions in vitro and in vivo. PMID: 17894227
    13. Results might suggest a potential and functional role for Dpl in tumor cells migratory and morphological behaviours and address to future gene-targeted therapeutic interventions. PMID: 18936526
    14. results suggested that the function of Dpl is antagonistic to PrP rather than synergistic PMID: 19129949

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Prion family
  • 組織特異性：
    Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).
  • 數據庫鏈接：

    HGNC: 15748

    OMIM: 604263

    KEGG: hsa:23627

    STRING: 9606.ENSP00000306900

    UniGene: Hs.406696



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