在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PRKAR2A Antibody

PRKAR2A Antibody

  • 中文名稱：
    PRKAR2A兔多克隆抗體
  • 貨號：
    CSB-PA030232
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using PKA IIα reg Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    cAMP dependent protein kinase regulatory subunit alpha 2 antibody; cAMP dependent protein kinase regulatory subunit RII alpha antibody; cAMP dependent protein kinase type II alpha regulatory chain antibody; cAMP dependent protein kinase type II alpha regulatory subunit antibody; cAMP-dependent protein kinase type II-alpha regulatory subunit antibody; KAP2 antibody; KAP2_HUMAN antibody; MGC3606 antibody; PKR 2 antibody; PKR2 antibody; PRKA R2 antibody; PRKAR 2 antibody; PRKAR2 antibody; PRKAR2A antibody; Protein kinase A RII alpha subunit antibody; Protein kinase cAMP dependent regulatory type II alpha antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PKA IIα reg.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
  • 基因功能參考文獻(xiàn)：
    1. High PK-R2 expression is associated with colorectal cancer. PMID: 26372733
    2. Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIalpha's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms. PMID: 26608815
    3. Disruption of Snapin-PKR2 interaction did not affect PKR2 signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2. PMID: 26687946
    4. we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity PMID: 25916936
    5. These data demonstrate that some Kallmann syndrome-associated, intracellularly retained mutant PKR2 receptors can be functionally rescued, suggesting a potential treatment strategy for patients bearing such mutations. PMID: 24753254
    6. Smad4 and the R subunit of the protein kinase A holoenzyme form a functional complex in vivo in response to TGFbeta. PMID: 23362281
    7. ETO nervy homology region (NHR) 3 domain-PKA(RIIalpha) protein interaction does not appear to significantly contribute to AML1-ETO's ability to induce leukemia. PMID: 20708017
    8. findings indicate that increased particulate type II protein kinase A activity occurs throughout pregnancy therefore directing the cAMP quiescence signal to specific subcellular loci within myometrial smooth muscle cells PMID: 12727975
    9. These data implicate the involvement of PKA-RIIalpha anchoring apical targeting of distinct proteins and glycosphingolipids to apical plasma membrane domains and suggest that rerouting may underlie the delayed Golgi-to-apical surface transport of MDR1. PMID: 16723498
    10. The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA in complex with the high-affinity anchoring peptide AKAP-IS explain the molecular basis for AKAP-regulatory subunit recognition. PMID: 17081989
    11. The data suggest that centrosomal anchoring of RIIalpha and the interrelated subapical positioning of these centrosomes is required for oncostatin M-, but not cAMP-mediated, bile canalicular lumen development. PMID: 17494870
    12. RIIalpha releases Calpha upon elevated cAMP alone, dependent on autophosphorylation of the RIIalpha inhibitory domain PMID: 17884635
    13. Bacillus anthracis edema toxin altered the protein levels and activity of protein kinase A and exchange protein activated by cAMP (Epac), a recently identified cAMP-binding molecule. PMID: 19307216

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
  • 蛋白家族：
    CAMP-dependent kinase regulatory chain family
  • 組織特異性：
    Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9391

    OMIM: 176910

    KEGG: hsa:5576

    STRING: 9606.ENSP00000265563

    UniGene: Hs.631923



主站蜘蛛池模板： 用舌头去添高潮无码视频| 9l国产精品久久久久麻豆| 亚洲中文字幕国产综合| 深夜福利小视频在线观看| 成熟丰满熟妇av无码区| 亚洲这里只有久热精品伊人| 日本欧美一区二区三区高清 | 中国国产免费毛卡片| 韩国19禁主播深夜福利视频| 在线观看片a免费不卡观看| 明星性猛交ⅹxxx乱大交| 亚洲va久久久噜噜噜久久天堂 | 激情偷乱人成视频在线观看| 日日摸夜夜摸狠狠摸婷婷| 亚洲老熟女与小伙bbwtv| 国产精品理论片| 西西人体大胆瓣开下部毛茸茸| 国产区精品一区二区不卡中文 | 成年女人毛片免费视频| 双腿张开被9个男人调教| 亚洲欧洲自拍拍偷精品网| 免费的av网站手机版| 亚洲字幕av一区二区三区四区 | 中国亚洲女人69内射少妇| 国产人成无码视频在线| 色欲天天天天天综合网| 东北老女人高潮大叫对白| 中文字幕欧美人妻精品一区| 亚洲另类欧美小说图片区| 99热在线精品国产观看| 国产日韩在线时看高清视频| 亚洲aⅴ综合色区无码一区| 国产午夜福利精品一区| 14萝自慰专用网站| 日韩精品毛片无码一区到三区| 国产一区二区三区在线视頻| 日韩中文无码有码免费视频| 中文字幕乱码中文乱码777| 国产手机在线亚洲精品观看| 亚洲 日韩 国产欧美 另类| 无码丰满熟妇|