在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRKAR2A Antibody, Biotin conjugated

  • 中文名稱:
    PRKAR2A兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA018697LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRKAR2A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    cAMP dependent protein kinase regulatory subunit alpha 2 antibody; cAMP dependent protein kinase regulatory subunit RII alpha antibody; cAMP dependent protein kinase type II alpha regulatory chain antibody; cAMP dependent protein kinase type II alpha regulatory subunit antibody; cAMP-dependent protein kinase type II-alpha regulatory subunit antibody; KAP2 antibody; KAP2_HUMAN antibody; MGC3606 antibody; PKR 2 antibody; PKR2 antibody; PRKA R2 antibody; PRKAR 2 antibody; PRKAR2 antibody; PRKAR2A antibody; Protein kinase A RII alpha subunit antibody; Protein kinase cAMP dependent regulatory type II alpha antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human cAMP-dependent protein kinase type II-alpha regulatory subunit protein (43-205AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
  • 基因功能參考文獻:
    1. High PK-R2 expression is associated with colorectal cancer. PMID: 26372733
    2. Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIalpha's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms. PMID: 26608815
    3. Disruption of Snapin-PKR2 interaction did not affect PKR2 signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2. PMID: 26687946
    4. we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity PMID: 25916936
    5. These data demonstrate that some Kallmann syndrome-associated, intracellularly retained mutant PKR2 receptors can be functionally rescued, suggesting a potential treatment strategy for patients bearing such mutations. PMID: 24753254
    6. Smad4 and the R subunit of the protein kinase A holoenzyme form a functional complex in vivo in response to TGFbeta. PMID: 23362281
    7. ETO nervy homology region (NHR) 3 domain-PKA(RIIalpha) protein interaction does not appear to significantly contribute to AML1-ETO's ability to induce leukemia. PMID: 20708017
    8. findings indicate that increased particulate type II protein kinase A activity occurs throughout pregnancy therefore directing the cAMP quiescence signal to specific subcellular loci within myometrial smooth muscle cells PMID: 12727975
    9. These data implicate the involvement of PKA-RIIalpha anchoring apical targeting of distinct proteins and glycosphingolipids to apical plasma membrane domains and suggest that rerouting may underlie the delayed Golgi-to-apical surface transport of MDR1. PMID: 16723498
    10. The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA in complex with the high-affinity anchoring peptide AKAP-IS explain the molecular basis for AKAP-regulatory subunit recognition. PMID: 17081989
    11. The data suggest that centrosomal anchoring of RIIalpha and the interrelated subapical positioning of these centrosomes is required for oncostatin M-, but not cAMP-mediated, bile canalicular lumen development. PMID: 17494870
    12. RIIalpha releases Calpha upon elevated cAMP alone, dependent on autophosphorylation of the RIIalpha inhibitory domain PMID: 17884635
    13. Bacillus anthracis edema toxin altered the protein levels and activity of protein kinase A and exchange protein activated by cAMP (Epac), a recently identified cAMP-binding molecule. PMID: 19307216

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
  • 蛋白家族:
    CAMP-dependent kinase regulatory chain family
  • 組織特異性:
    Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 數據庫鏈接:

    HGNC: 9391

    OMIM: 176910

    KEGG: hsa:5576

    STRING: 9606.ENSP00000265563

    UniGene: Hs.631923



主站蜘蛛池模板: 97精品一区二区视频在线观看| 高清国产亚洲精品自在久久| 亚洲欧美日韩久久一区二区| 伊人久久大香线蕉aⅴ色| 欧美日韩视频在线第一区| 国产精品成人午夜久久| 国产精品久久久久久亚洲色| 青青草97国产精品免费观看| 成人免费一区二区三区视频| 免费观看啪啪黄的网站| 日本成熟少妇喷浆视频| 久久精品国产网红主播| 日本熟妇浓毛| 18禁女裸乳扒开免费视频| 国产精品卡1卡2卡三卡四| 饥渴丰满少妇大力进入| 97精品尹人久久大香线蕉| 波多野结衣办公室33分钟| 4hu四虎永久免费地址ww416| 少妇愉情理伦片丰满丰满午夜| 最新版天堂资源中文官网| 久久天天躁狠狠躁夜夜2o2o| 久久不见久久见免费影院www | 亚洲精品第一国产综合亚av| 久久不见久久见免费视频6无删减| 亚洲一本一道一区二区三区| 最新高清无码专区| 熟女人妻在线视频| 夜夜欢性恔免费视频| 日本丰满大乳乳液| 欧美性潮喷xxxxx免费视频看| 天天弄天天模| 久天啪天天久久99久久| 青草国产精品久久久久久| 大黑人交xxxx18视频| 国产爆乳无码一区二区麻豆| 人妻一区二区三区高清av专区| 少妇无码av无码去区钱| 无套内谢的新婚少妇国语播放| 国产精品高清视亚洲中文| 隔壁人妻被水电工征服|