在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRKAR2A Antibody

  • 中文名稱:
    PRKAR2A兔多克隆抗體
  • 貨號:
    CSB-PA018697GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    cAMP dependent protein kinase regulatory subunit alpha 2 antibody; cAMP dependent protein kinase regulatory subunit RII alpha antibody; cAMP dependent protein kinase type II alpha regulatory chain antibody; cAMP dependent protein kinase type II alpha regulatory subunit antibody; cAMP-dependent protein kinase type II-alpha regulatory subunit antibody; KAP2 antibody; KAP2_HUMAN antibody; MGC3606 antibody; PKR 2 antibody; PKR2 antibody; PRKA R2 antibody; PRKAR 2 antibody; PRKAR2 antibody; PRKAR2A antibody; Protein kinase A RII alpha subunit antibody; Protein kinase cAMP dependent regulatory type II alpha antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PRKAR2A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
  • 基因功能參考文獻(xiàn):
    1. High PK-R2 expression is associated with colorectal cancer. PMID: 26372733
    2. Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIalpha's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms. PMID: 26608815
    3. Disruption of Snapin-PKR2 interaction did not affect PKR2 signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2. PMID: 26687946
    4. we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity PMID: 25916936
    5. These data demonstrate that some Kallmann syndrome-associated, intracellularly retained mutant PKR2 receptors can be functionally rescued, suggesting a potential treatment strategy for patients bearing such mutations. PMID: 24753254
    6. Smad4 and the R subunit of the protein kinase A holoenzyme form a functional complex in vivo in response to TGFbeta. PMID: 23362281
    7. ETO nervy homology region (NHR) 3 domain-PKA(RIIalpha) protein interaction does not appear to significantly contribute to AML1-ETO's ability to induce leukemia. PMID: 20708017
    8. findings indicate that increased particulate type II protein kinase A activity occurs throughout pregnancy therefore directing the cAMP quiescence signal to specific subcellular loci within myometrial smooth muscle cells PMID: 12727975
    9. These data implicate the involvement of PKA-RIIalpha anchoring apical targeting of distinct proteins and glycosphingolipids to apical plasma membrane domains and suggest that rerouting may underlie the delayed Golgi-to-apical surface transport of MDR1. PMID: 16723498
    10. The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA in complex with the high-affinity anchoring peptide AKAP-IS explain the molecular basis for AKAP-regulatory subunit recognition. PMID: 17081989
    11. The data suggest that centrosomal anchoring of RIIalpha and the interrelated subapical positioning of these centrosomes is required for oncostatin M-, but not cAMP-mediated, bile canalicular lumen development. PMID: 17494870
    12. RIIalpha releases Calpha upon elevated cAMP alone, dependent on autophosphorylation of the RIIalpha inhibitory domain PMID: 17884635
    13. Bacillus anthracis edema toxin altered the protein levels and activity of protein kinase A and exchange protein activated by cAMP (Epac), a recently identified cAMP-binding molecule. PMID: 19307216

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
  • 蛋白家族:
    CAMP-dependent kinase regulatory chain family
  • 組織特異性:
    Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9391

    OMIM: 176910

    KEGG: hsa:5576

    STRING: 9606.ENSP00000265563

    UniGene: Hs.631923



主站蜘蛛池模板: 日韩国产亚洲一区二区三区| 香港台湾经典三级a视频| 久久久橹橹橹久久久久高清| 性一交一乱一伦一| 亚洲国产午夜精品理论片妓女| 亚洲天堂在线观看完整版| 好爽好黄的视频| 中国大陆高清aⅴ毛片| 风韵犹存丰满大屁股熟妇| 亚洲精品午夜无码电影网| 国产精品久久久一区二区三区| 亚洲色大成网站www| 西西人体扒开下部试看120秒 | 精品国产福利拍拍拍| 大陆熟妇丰满多毛xxxx| 久久99精品久久久久婷婷暖| 国产美女口爆吞精普通话| 99精品国产综合久久久久五月天 | 午夜dv内射一区二区| √最新版天堂资源网在线| 亚洲日产av中文字幕无码偷拍| 精品一卡2卡3卡4卡新区在线| 99久久久无码国产精品9| 免费人妻精品一区二区三区 | 一本大道东京热无码视频| 少妇无码一区二区三区免费| 亚洲乱亚洲乱妇小说网| 日本熟妇色高清免费视频| 午夜精品影视国产一区在线麻豆 | 黄网站色视频免费国产| 欧美精欧美乱码一二三四区| 成在线人视频免费视频| 牲欲强的熟妇农村老妇女视频| 99精品产国品一二三产区| 欧美中日韩免费观看网站| 国产精品久久久久9999赢消 | 综合色区国产亚洲另类| 国产精品久久久久aaaa| 欧美日韩国产免费一区二区三区| 天堂在线www资源在线| 亚洲欧洲精品成人久久曰影片|