在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRKACB Antibody

  • 中文名稱:
    PRKACB兔多克隆抗體
  • 貨號:
    CSB-PA987088
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Jurkat cells and COLO205 cells, using KAPCB antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PRKACB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human KAPCB.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA.
  • 基因功能參考文獻(xiàn):
    1. Cbeta2 subunit of protein kinase A mRNA was up-regulated in prostate cancer and low expression of Cbeta2 mRNA in prostate cancer biopsies correlated with poor survival. PMID: 27838142
    2. analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 PMID: 25831493
    3. The gene polymorphism loci rs12132032 in PRKACB maybe a potential risk factor for anencephaly in Chinese population from Shanxi, while gender susceptibility may influence the correlation. PMID: 24294386
    4. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified. PMID: 20564261
    5. activated by podophyllotoxin PMID: 20033853
    6. PGE(2)-induced CYP1B1 expression is mediated by ligand-independent activation of the ERalpha pathway as a result of the activation of ERK, Akt, and PKA in breast cancer cells. PMID: 20093341
    7. Data show that PI3K activation and PIP3 production lead to recruitment of the PKB/beta-arrestin/PDE4 complex to the membrane via the PKB PH domain, resulting in degradation of the TCR-induced cAMP pool and allowing full T-cell activation to proceed. PMID: 20086095
    8. c-MYC induces the activity of protein kinase A by inducing the transcription of the gene encoding the PKA catalytic subunit beta in multiple tissues, independent of cell proliferation by direct binding of c-MYC to promoter sequences. PMID: 12420224
    9. Data describe the identification of a variant of the beta catalytic subunit of cyclic AMP-dependent protein kinase (PKACbeta) as a p75 neurotrophin receptor(NTR)-interacting protein, which phosphorylates p75(NTR) at Ser304. PMID: 12682012
    10. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta. PMID: 14744463
    11. there is a PKA-Cbeta-mediated inhibitory mechanism of p73 function PMID: 15723830
    12. Murine lymphoid tissues express a protein that is a homologue of human protein kinase c subunit beta2 PMID: 16889664
    13. In conclusion, it seems that the Cbeta isoforms of PKA play different roles in proliferation and differentiation and could therefore be potential markers for prostate cancer progression. PMID: 16949795
    14. Data provide the first evidence that Protein kinase C -beta play pivotal role in the regulation of AA production and cellular proliferation of human monocytoid MonoMac-6 cells. PMID: 17549442
    15. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. PMID: 18499756

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
  • 組織特異性:
    Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9381

    OMIM: 176892

    KEGG: hsa:5567

    STRING: 9606.ENSP00000359719

    UniGene: Hs.487325



主站蜘蛛池模板: 国产成人精品无码播放| 欧美日本特级婬片视频| 亚洲aⅴ综合av国产八av| 久久国产精品久久精品国产| 美女张开腿让男人桶爽| 大乳丰满人妻中文字幕日本电影 | 无码中文字幕乱在线观看| 天堂在线最新版资源www中文| 少妇性俱乐部纵欲狂欢电影| 国产漂亮白嫩美女在线观看| 综合色就爱涩涩涩综合婷婷| 国产精品偷窥熟女精品视频| 人妻少妇偷人精品无码| 久热这里只有精品视频6| 人妻出轨av中文字幕| 国产精品无码av不卡顿| 国产一线二线三线女| 色情无码一区二区三区| 尤物色综合欧美五月俺也去| 国产爆乳成av人在线播放| 疯狂做受xxxx高潮视频免费| 四虎永久在线精品免费视频观看 | 青草青草久热国产精品| 国产萌白酱喷水视频在线播放| 青青草国产精品久久久久| 日韩精品一区二区三区视频 | 韩国三级在线观看久| 一二三四视频社区3在线高清| 西西艺术人像摄影| 男女啪啪激烈高潮喷出gif免费| 国产精品人人妻人人爽人人牛| 日韩精品人妻系列无码专区| 久久天天躁夜夜躁狠狠躁2014| 无码av无码天堂资源网影音先锋| 国产一区二区三区在线观看 | 国产精品无码制服丝袜| 丰满岳乱妇在线观看中字| 青青草国产精品人人爱| 天堂在线中文| 国产又色又爽无遮挡免费| 成人影院永久免费观看网址|